Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fernando González-Nilo"'
Autor:
Manuel I. Osorio, Mircea Petrache, Dino G. Salinas, Felipe Valenzuela-Ibaceta, Fernando González-Nilo, William Tiznado, José M. Pérez-Donoso, Denisse Bravo, Osvaldo Yáñez
Publikováno v:
Symmetry, Vol 15, Iss 12, p 2176 (2023)
The Michaelis–Menten mechanism, which describes the binding of a substrate to an enzyme, is a simplification of the process on a molecular scale. A more detailed model should include the binding of the substrate to precatalytic binding sites (PCBSs
Externí odkaz:
https://doaj.org/article/9e46df14620b403db8ee4f327d2e264a
Autor:
Romina V. Sepulveda, Christopher Sbarbaro, Ma Cecilia Opazo, Yorley Duarte, Fernando González-Nilo, Daniel Aguayo
Publikováno v:
Membranes, Vol 13, Iss 5, p 469 (2023)
The origin of life possibly required processes in confined systems that facilitated simple chemical reactions and other more complex reactions impossible to achieve under the condition of infinite dilution. In this context, the self-assembly of micel
Externí odkaz:
https://doaj.org/article/b04f9b512f934ba2b1f71bc973331f4f
Autor:
Manuel I. Osorio, Nicolás Bruna, Víctor García, Lisdelys González-Rodríguez, Matías S. Leal, Francisco Salgado, Matías Vargas-Reyes, Fernando González-Nilo, José M. Pérez-Donoso, Osvaldo Yáñez
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 400 (2022)
Xenobiotic reductase B (XenB) catalyzes the reduction of the aromatic ring or nitro groups of nitroaromatic compounds with methyl, amino or hydroxyl radicals. This reaction is of biotechnological interest for bioremediation, the reuse of industrial w
Externí odkaz:
https://doaj.org/article/fa7b7fcb13a644d891d0c17d9e5a6d87
Autor:
Osvaldo Yañez, Manuel Isaías Osorio, Carlos Areche, Alejandro Vasquez-Espinal, Jessica Bravo, Angélica Sandoval-Aldana, José M. Pérez-Donoso, Fernando González-Nilo, Maria João Matos, Edison Osorio, Olimpo García-Beltrán, William Tiznado
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss , Pp 111764- (2021)
Cocoa beans contain antioxidant molecules with the potential to inhibit type 2 coronavirus (SARS-CoV-2), which causes a severe acute respiratory syndrome (COVID-19). In particular, protease. Therefore, using in silico tests, 30 molecules obtained fro
Externí odkaz:
https://doaj.org/article/6fcab25d03e0492c9fa5c0f483560e92
Autor:
Manuel I. Osorio, Osvaldo Yáñez, Mauricio Gallardo, Matías Zuñiga-Bustos, Jorge Mulia-Rodríguez, Roberto López-Rendón, Olimpo García-Beltrán, Fernando González-Nilo, José M. Pérez-Donoso
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 986 (2022)
The rapid emergence and spread of new variants of coronavirus type 2, as well as the emergence of zoonotic viruses, highlights the need for methodologies that contribute to the search for new pharmacological treatments. In the present work, we search
Externí odkaz:
https://doaj.org/article/bad74775dd084d21b1e015420c7d0505
Autor:
Osvaldo Yañez, Manuel Isaías Osorio, Eugenio Uriarte, Carlos Areche, William Tiznado, José M. Pérez-Donoso, Olimpo García-Beltrán, Fernando González-Nilo
Publikováno v:
Frontiers in Chemistry, Vol 8 (2021)
The pandemic that started in Wuhan (China) in 2019 has caused a large number of deaths, and infected people around the world due to the absence of effective therapy against coronavirus 2 of the severe acute respiratory syndrome (SARS-CoV-2). Viral ma
Externí odkaz:
https://doaj.org/article/989ba5b657e0463bb4b90c42dfdd77fb
Autor:
Yorley Duarte, Javier Cáceres, Romina V. Sepúlveda, Diego Arriagada, Pedro Olivares, Ignacio Díaz-Franulic, Jimmy Stehberg, Fernando González-Nilo
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a member of the family of Transient Receptor Potential (TRP) channels that acts as a molecular detector of noxious signals in primary sensory neurons. Activated by capsaicin, heat, v
Externí odkaz:
https://doaj.org/article/ecdc815e5a374d7ba0cd0124c6e8daa3
Autor:
Yorley Duarte, Maximiliano Rojas, Jonathan Canan, Edwin G. Pérez, Fernando González-Nilo, Jesús García-Colunga
Publikováno v:
Molecules, Vol 26, Iss 4, p 998 (2021)
Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a different structure and pharmacological profile modulate the rat α7 nAChR th
Externí odkaz:
https://doaj.org/article/a247fffc207b49e6b738d1854196da0e
Autor:
Ximena López, Rosalba Escamilla, Paola Fernández, Yorley Duarte, Fernando González-Nilo, Nicolás Palacios-Prado, Agustín D. Martinez, Juan C. Sáez
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9180 (2020)
Pannexin 1 channels located in the cell membrane are permeable to ions, metabolites, and signaling molecules. While the activity of these channels is known to be modulated by phosphorylation on T198, T308, and S206, the possible involvement of other
Externí odkaz:
https://doaj.org/article/b0c90a674b514276897ebb2bc05c4683
Autor:
Fernando González-Nilo, Tomás Pérez-Acle, Sergio Guínez-Molinos, Daniela A Geraldo, Claudia Sandoval, Alejandro Yévenes, Leonardo S Santos, V. Felipe Laurie, Hegaly Mendoza, Raúl E Cachau
Publikováno v:
Biological Research, Vol 44, Iss 1, Pp 43-51 (2011)
After the progress made during the genomics era, bioinformatics was tasked with supporting the flow of information generated by nanobiotechnology efforts. This challenge requires adapting classical bioinformatic and computational chemistry tools to s
Externí odkaz:
https://doaj.org/article/3e7f186aeb7e401c8bd2a484c58a0200