Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Fernando González, Ibáñez"'
Autor:
Rudy G. Jacquet, Fernando González Ibáñez, Katherine Picard, Lucy Funes, Mohammadparsa Khakpour, Gunnar K. Gouras, Marie-Ève Tremblay, Frederick R. Maxfield, Santiago Solé-Domènech
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 115052- (2024)
Summary: How microglia digest Alzheimer’s fibrillar amyloid-beta (Aβ) plaques that are too large to be phagocytosed is not well understood. Here, we show that primary microglial cells create acidic extracellular compartments, lysosomal synapses, o
Externí odkaz:
https://doaj.org/article/4cc3189622f347658520a736aac382bc
Publikováno v:
Open Biology, Vol 14, Iss 11 (2024)
Psychological stress is the major risk factor for major depressive disorder. Sustained stress causes changes in behaviour, brain connectivity and in its cells and organelles. Resilience to stress is understood as the ability to recover from stress in
Externí odkaz:
https://doaj.org/article/5db7cc61ddf24f2abf33b6d99c1a1096
Autor:
Micaël Carrier, Marie-Ève Robert, Marie-Kim St-Pierre, Fernando González Ibáñez, Elisa Gonçalves de Andrade, Audrée Laroche, Katherine Picard, Haley A. Vecchiarelli, Julie C. Savage, Éric Boilard, Michèle Desjardins, Marie-Ève Tremblay
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110037- (2024)
Summary: Although the roles of embryonic yolk sac-derived, resident microglia in neurodevelopment were extensively studied, the possible involvement of bone marrow-derived cells remains elusive. In this work, we used a fate-mapping strategy to select
Externí odkaz:
https://doaj.org/article/bf4a91ff75b7430f937daad11da42e1d
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Traumatic spinal cord injury can cause immediate physical damage to the spinal cord and result in severe neurological deficits. The primary, mechanical tissue damage triggers a variety of secondary damage mechanisms at the injury site which
Externí odkaz:
https://doaj.org/article/74923b5f941e4dbd8dcfd5a4c89d7451
Autor:
Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, Martin Parent, Marie-Ève Tremblay
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-27 (2023)
Abstract The past decade has witnessed increasing evidence for a crucial role played by glial cells, notably astrocytes, in Alzheimer’s disease (AD). To provide novel insights into the roles of astrocytes in the pathophysiology of AD, we performed
Externí odkaz:
https://doaj.org/article/20307c08ad6b4ccb9ba82d74e2a7f672
Autor:
Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Eva Šimončičová, Marie-Josée Wallman, Luc Vallières, Martin Parent, Marie-Ève Tremblay
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-22 (2022)
Abstract A diverse heterogeneity of microglial cells was previously described in Alzheimer’s disease (AD) pathology, including dark microglia, a state characterized by ultrastructural markers of cellular stress. To provide novel insights into the r
Externí odkaz:
https://doaj.org/article/49c48042062d4eb0a0040c4b24fcd39b
Autor:
Olus Uyar, Juan Manuel Dominguez, Maude Bordeleau, Lina Lapeyre, Fernando González Ibáñez, Luc Vallières, Marie-Eve Tremblay, Jacques Corbeil, Guy Boivin
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-24 (2022)
Abstract Background Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized. We sought to identify different
Externí odkaz:
https://doaj.org/article/117a18aab4ef4e7aaf55f16ef2414676
Autor:
Maude Bordeleau, Cesar H. Comin, Lourdes Fernández de Cossío, Chloé Lacabanne, Moises Freitas-Andrade, Fernando González Ibáñez, Joanna Raman-Nair, Michael Wakem, Mallar Chakravarty, Luciano da F. Costa, Baptiste Lacoste, Marie-Ève Tremblay
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
In order to advance our understanding of the effects of maternal high-fat diet (mHFD) on the cerebrovascular health of offspring, Bordeleau et al. use a translational mouse model of mHFD exposure. They demonstrate that mHFD induces cerebrovascular an
Externí odkaz:
https://doaj.org/article/61fe181699fb475688118bd0a7eb9e3b
Autor:
William Enlow, Maude Bordeleau, Jocelyne Piret, Fernando González Ibáñez, Olus Uyar, Marie-Christine Venable, Nathalie Goyette, Julie Carbonneau, Marie-Eve Tremblay, Guy Boivin
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-24 (2021)
Abstract Background Zika virus (ZIKV) has been associated with several neurological complications in adult patients. Methods We used a mouse model deficient in TRIF and IPS-1 adaptor proteins, which are involved in type I interferon production, to st
Externí odkaz:
https://doaj.org/article/61b54970aaf9428c9213858eb51ea03d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Suicide is a complex public health challenge associated worldwide with one death every 40 s. Research advances in the neuropathology of suicidal behaviors (SB) have defined discrete brain changes which may hold the key to suicide prevention. Physiolo
Externí odkaz:
https://doaj.org/article/dfb69e6209714c459030d917d8ed2022