Transcription factor induced conversion of human fibroblasts towards the hair cell lineage.

Autor: María Beatriz Duran Alonso, Iris Lopez Hernandez, Miguel Angel de la Fuente, Javier Garcia-Sancho, Fernando Giraldez, Thomas Schimmang

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200210 (2018)

Hearing loss is the most common sensorineural disorder, affecting over 5% of the population worldwide. Its most frequent cause is the loss of hair cells (HCs), the mechanosensory receptors of the cochlea. HCs transduce incoming sounds into electrical

Externí odkaz: https://doaj.org/article/47ff49a6092e429db122498d08f2bba3

The prosensory function of Sox2 in the chicken inner ear relies on the direct regulation of Atoh1.

Autor: Joana Neves, Masanori Uchikawa, Anna Bigas, Fernando Giraldez

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30871 (2012)

The proneural gene Atoh1 is crucial for the development of inner ear hair cells and it requires the function of the transcription factor Sox2 through yet unknown mechanisms. In the present work, we used the chicken embryo and HEK293T cells to explore

Externí odkaz: https://doaj.org/article/e6d3f4ac9095469d9be29c6c52d46f97

Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons

Autor: Gina Abelló, Héctor Gálvez, Fernando Giraldez

Publikováno v: Frontiers in Cell and Developmental Biology
Recercat. Dipósit de la Recerca de Catalunya
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Integration between cell signals and bHLH transcription factors plays a prominent role during the development of hair cells of the inner ear. Hair cells are the sensory receptors of the inner ear, responsible for the mechano-transduction of sound wav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef5599d2811de641895ee35d2e3c682
http://europepmc.org/articles/PMC5364141

Sox2 regulation of hair cell development: incoherence makes sense

Autor: Ivan H. Vachkov, Joana Neves, Fernando Giraldez

Publikováno v: Hearing Research. 297:20-29

The function of the inner ear relies on different specialized cell types: hair cells, supporting cells and otic neurons. During development, these cell types are generated from the neurosensory domain of the otic placode with a stereotyped spatial an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f6708b78fe871f4d875bdba3e8b0f1
https://doi.org/10.1016/j.heares.2012.11.003

Spatial and temporal segregation of auditory and vestibular neurons in the otic placode

Autor: Isabel Varela-Nieto, Berta Alsina, Andrea Streit, Donald Bell, Itziar Gorospe, Fernando Giraldez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Bell, D, Streit, A, Gorospe, I, Varela-Nieto, I, Alsina, B & Giraldez, F 2008, ' Spatial and temporal segregation of auditory and vestibular neurons in the otic placode ', Developmental Biology, vol. 322, no. 1, pp. 109-120 . https://doi.org/10.1016/j.ydbio.2008.07.011

This is an article Open Access.
The otic placode generates the auditory and vestibular sense organs and their afferent neurons; however, how auditory and vestibular fates are specified is unknown. We have generated a fate map of the otic placode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0679515dd8501a60fe3829ee11c573