Výsledky vyhledávání - "Fernando F Costa"

Akademický článek

Economic burden of sickle cell disease in Brazil.

Autor: Ana Cristina Silva-Pinto, Fernando F Costa, Sandra Fatima Menosi Gualandro, Patricia Belintani Blum Fonseca, Carmela Maggiuzzu Grindler, Homero C R Souza Filho, Carolina Tosin Bueno, Rodolfo D Cançado

Publikováno v: PLoS ONE, Vol 17, Iss 6, p e0269703 (2022)

BackgroundSickle cell disease (SCD) may cause several impacts to patients and the whole society. About 4% of the population has the sickle cell trait in Brazil, and 60,000 to 100,000 have SCD. However, despite recognizing the significant burden of di

Externí odkaz: https://doaj.org/article/81db4a20c2ff41a0b7b4d95b22fd8c81

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Akademický článek

Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition.

Autor: Pamela L Brito, Alisson F Dos Santos, Hanan Chweih, Maria E Favero, Erica M F Gotardo, Juliete A F Silva, Flavia C Leonardo, Carla F Franco-Penteado, Mariana G de Oliveira, Wilson A Ferreira, Bruna C Zaidan, Athanase Billis, Giorgio Baldanzi, Denise A Mashima, Edson Antunes, Sara T Olalla Saad, Fernando F Costa, Nicola Conran

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0263424 (2022)

BackgroundSickle cell disease (SCD) incurs vaso-occlusive episodes and organ damage, including nephropathy. Despite displaying characteristics of vascular dysfunction, SCD patients tend to present relatively lower systemic blood pressure (BP), via an

Externí odkaz: https://doaj.org/article/bc15c8b661e143f09d6ae6182aef78cd

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Akademický článek

Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.

Autor: Karen S Romanello, Karina K L Teixeira, João Pedro M O Silva, Sheila T Nagamatsu, Marcos André C Bezerra, Igor F Domingos, Diego A P Martins, Aderson S Araujo, Carolina Lanaro, Carlos A Breyer, Regiane A Ferreira, Carla Franco-Penteado, Fernando F Costa, Iran Malavazi, Luis E S Netto, Marcos A de Oliveira, Anderson F Cunha

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0208316 (2018)

β-thalassemia is a worldwide distributed monogenic red cell disorder, characterized by an absent or reduced beta globin chain synthesis. The unbalance of alpha-gamma chain and the presence of pathological free iron promote severe oxidative damage, p

Externí odkaz: https://doaj.org/article/4b78522957f34bf29516daf39d4e0b8c

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Akademický článek

Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition

Autor: Érica M. F. Gotardo, Lidiane S. Torres, Bruna Cunha Zaidan, Lucas F. S. Gushiken, Pâmela L. Brito, Flavia C. Leonardo, Claudia H. Pellizzon, John Millholland, Sergei Agoulnik, Jiri Kovarik, Fernando F. Costa, Nicola Conran

Publikováno v: Haematologica, Vol 999, Iss 1 (2024)

Continuous vaso-occlusive and inflammatory processes cause extensive end-organ damage in adults with sickle cell disease (SCD), and there is little evidence that longterm hydroxyurea therapy prevents this. In initial trials, P-selectin blockade with

Externí odkaz: https://doaj.org/article/c8bf205ecd7f4affb0b6ca4d18ffe84d

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Akademický článek

Sympathetic Hyperactivity, Increased Tyrosine Hydroxylase and Exaggerated Corpus Cavernosum Relaxations Associated with Oxidative Stress Plays a Major Role in the Penis Dysfunction in Townes Sickle Cell Mouse.

Autor: Fábio H Silva, Mário A Claudino, Fabiano B Calmasini, Eduardo C Alexandre, Carla Franco-Penteado, Arthur L Burnett, Edson Antunes, Fernando F Costa

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0166291 (2016)

Sickle cell disease patients display priapism that may progress to erectile dysfunction. However, little is known about the pathophysiological alterations of corpus cavernosum in sickle cell disease.Thus, this study aimed to evaluate the functional a

Externí odkaz: https://doaj.org/article/1d3df120b7c0499a94be717405787fb4

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Akademický článek

Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications.

Autor: Daniela P Leonardo, Dulcinéia M Albuquerque, Carolina Lanaro, Letícia C Baptista, José G Cecatti, Fernanda G Surita, Mary A Parpinelli, Fernando F Costa, Carla F Franco-Penteado, Kleber Y Fertrin, Maria Laura Costa

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0136693 (2015)

Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality in the world, but its appearance is still unpredictable and its pathophysiology has not been entirely elucidated. Genetic studies have associated single nucleo

Externí odkaz: https://doaj.org/article/2c2ce5b846c74c2a90a260123d6c6f76

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