Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Fernando E Sepulveda"'
Autor:
Claire Soudais, Romane Schaus, Camille Bachelet, Norbert Minet, Sara Mouasni, Cécile Garcin, Caique Lopes Souza, Pierre David, Clara Cousu, Hélène Asnagli, Andrew Parker, Paul Palmquist-Gomes, Fernando E. Sepulveda, Sébastien Storck, Sigolène M. Meilhac, Alain Fischer, Emmanuel Martin, Sylvain Latour
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency,
Externí odkaz:
https://doaj.org/article/2ee4154d2b4c4068995febb02c537e32
Autor:
Sophia Maschalidi, Signe Hässler, Fany Blanc, Fernando E Sepulveda, Mira Tohme, Michel Chignard, Peter van Endert, Mustapha Si-Tahar, Delphyne Descamps, Bénédicte Manoury
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002841 (2012)
Intracellular Toll-like receptors (TLRs) expressed by dendritic cells recognize nucleic acids derived from pathogens and play an important role in the immune responses against the influenza virus (IAV), a single-stranded RNA sensed by different recep
Externí odkaz:
https://doaj.org/article/623955a6ac4443deb2789d13f0191415
Autor:
Claire Leveau, Tania Gajardo, Marie-Thérèse El-Daher, Nicolas Cagnard, Alain Fischer, Geneviève de Saint Basile, Fernando E. Sepulveda
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
The molecular machinery that regulates the balance between self-renewal and differentiation properties of hematopoietic stem cells (HSC) has yet to be characterized in detail. Here we found that the tetratricopeptide repeat domain 7 A (Ttc7a) protein
Externí odkaz:
https://doaj.org/article/2bc8e9f8cac840b68e21d3a536395535
Autor:
Tayebeh Soheili, Amandine Durand, Fernando E. Sepulveda, Julie Rivière, Chantal Lagresle-Peyrou, Hanem Sadek, Geneviève de Saint Basile, Samia Martin, Fulvio Mavilio, Marina Cavazzana, Isabelle André-Schmutz
Publikováno v:
Blood Advances, Vol 1, Iss 27, Pp 2781-2789 (2017)
Abstract: Patients with mutations in the UNC13D gene (coding for Munc13-4 protein) suffer from familial hemophagocytic lymphohistiocytosis type 3 (FHL3), a life-threatening immune and hyperinflammatory disorder. The only curative treatment is allogen
Externí odkaz:
https://doaj.org/article/96f17802a96f484f96e5f9a61eee4791
Autor:
Cyril Longé, Manuela Bratti, Mathieu Kurowska, Shamila Vibhushan, Pierre David, Valère Desmeure, Jian-Dong Huang, Alain Fischer, Geneviève de Saint Basile, Fernando E. Sepulveda, Ulrich Blank, Gaël Ménasché
Publikováno v:
Journal of Allergy and Clinical Immunology. 150:676-689
Mast cells (MCs) are key effectors of the allergic response. Following the cross-linking of IgE receptors (FcεRIs), they release crucial inflammatory mediators through degranulation. Although degranulation depends critically on secretory granule (SG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389839c1bb4f842b6b3bccdfd5ac2987
https://doi.org/10.1016/j.jaci.2022.04.009
https://doi.org/10.1016/j.jaci.2022.04.009
Autor:
Marie-Thérèse El-Daher, Julie Lemale, Julie Bruneau, Claire Leveau, Frédéric Guerin, Nathalie Lambert, Jean-Sébastien Diana, Bénédicte Neven, Fernando E. Sepulveda, Aurore Coulomb-L'Hermine, Thierry Molina, Capucine Picard, Alain Fischer, Geneviève de Saint Basile
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Mutations in the tetratricopeptide repeat domain 7A (TTC7A) gene cause very early onset inflammatory bowel diseases (VOIBD) or multiple intestinal atresia associated with immune deficiency of various severities, ranging from combined immune deficienc
Externí odkaz:
https://doaj.org/article/2eee4e6109d1419e85a9d7180c1803fa
Autor:
Charlotte Boussard, Laure Delage, Tania Gajardo, Alexandre Kauskot, Maxime Batignes, Nicolas Goudin, Marie-Claude Stolzenberg, Camille Brunaud, Patricia Panikulam, Quentin Riller, Maryse Moya-Nilges, Jean Solarz, Christelle Reperant, Béatrice Durel, Jean-Claude Bordet, Olivier Pellé, Corinne Lebreton, Aude Magerus-Chatinet, Vithura Pirabakaran, Pablo Vargas, Sébastien Dupichaud, Marie Jeanpierre, Angélique Vinit, Mohammed Zarhrate, Cécile Masson, Nathalie Aladjidi, Peter D Arkwright, Brigitte Bader-Meunier, Sandrine Baron Joly, Joy Benadiba, Elise Bernard, Dominique Berrebi, Christine Bodemer, Martin Castelle, Fabienne Charbit-Henrion, Marwa Chbihi, Agathe Debray, Philippe Drabent, Sylvie Fraitag, Miguel Hié, Judith Landman-Parker, Ludovic Lhermitte, Despina Moshous, Pierre Rohrlich, Frank M Ruemmele, Anne Welfringer-Morin, Maud Tusseau, Alexandre Belot, Nadine Cerf-Bensussan, Marie Roelens, Capucine Picard, Bénédicte Neven, Alain Fischer, Isabelle Callebaut, Mickaël Mathieu Ménager, Fernando E Sepulveda, Frédéric Adam, Frédéric Rieux-Laucat
Publikováno v:
Blood.
Dedicator of cytokinesis (DOCK) proteins play a central role in actin cytoskeleton regulation. This is highlighted by the DOCK2 and DOCK8 deficiencies leading to actinopathies and immune deficiencies. DOCK8 and DOCK11 activate CDC42, a RHO-GTPase inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dec96e6c500a8e49ae90f50f39299caa
https://doi.org/10.1182/blood.2022018486
https://doi.org/10.1182/blood.2022018486
Autor:
Mohammed H. Mosa, Ophélie Nicolle, Sophia Maschalidi, Fernando E. Sepulveda, Aurelien Bidaud-Meynard, Constantin Menche, Birgitta E. Michels, Grégoire Michaux, Geneviève de Saint Basile, Henner F. Farin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 4, Pp 477-493.e1 (2018)
Background & Aims: Microvillus inclusion disease (MVID) is a congenital intestinal malabsorption disorder caused by defective apical vesicular transport. Existing cellular models do not fully recapitulate this heterogeneous pathology. The aim of this
Externí odkaz:
https://doaj.org/article/ef293e491f7240379703b18ddd4ab05a
Autor:
Leishemba K. Thoidingjam, Cédric M. Blouin, Christine Gaillet, Aurélien Brion, Stéphanie Solier, Supaporn Niyomchon, Ahmed El Marjou, Sara Mouasni, Fernando E. Sepulveda, Geneviève de Saint Basile, Christophe Lamaze, Raphaël Rodriguez
Publikováno v:
Angewandte Chemie International Edition. 61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe97696ee47c0a32545932d608e59f9c
https://doi.org/10.1002/anie.202208986
https://doi.org/10.1002/anie.202208986
Autor:
Leishemba K. Thoidingjam, Cédric M. Blouin, Christine Gaillet, Aurélien Brion, Stéphanie Solier, Supaporn Niyomchon, Ahmed El Marjou, Sara Mouasni, Fernando E. Sepulveda, Geneviève de Saint Basile, Christophe Lamaze, Raphaël Rodriguez
Publikováno v:
Angewandte Chemie. 134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38e22531871037fe9b79c7dfbae1375d
https://doi.org/10.1002/ange.202208986
https://doi.org/10.1002/ange.202208986