Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Fernando Donate"'
Autor:
Xiang Xu, Yuan Cai, Ying Wei, Fernando Donate, Jose Juarez, Graham Parry, Liqing Chen, Edward J Meehan, Richard W Ahn, Andrey Ugolkov, Oleksii Dubrovskyi, Thomas V O'Halloran, Mingdong Huang, Andrew P Mazar
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85349 (2014)
The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and
Externí odkaz:
https://doaj.org/article/0173507ab52c4bee81931476328e41db
Autor:
Karen Morrison, Hector Aviña, Sathish Kumar Ganesan, Jimmy Ou, Veronica Robles, Josh Snyder, Zhilan Zeng, Hui Zhao, Sher Bahadur Karki, Fernando Donate, David R. Stover, Lisa Do, Sara Gulesserian
Publikováno v:
Molecular Cancer Therapeutics. 16:1877-1886
Thrombocytopenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC), including AGS-16C3F, an ADC targeting ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase-3) and trastuzumab emtansine (T-DM1). This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7868f293260a94c5e6f60e2b8beb08
https://doi.org/10.1158/1535-7163.mct-16-0710
https://doi.org/10.1158/1535-7163.mct-16-0710
Autor:
Mi Sook Chang, Fernando Donate, Michael D. Mattie, Sara Gulesserian, Melissa M. Williams, Sathish Kumar Ganesan, Zhilan Zeng, Hui Zhao, David R. Stover, Brian A. Mendelsohn, Maria-Christina Malinao, James Song
Publikováno v:
Molecular Cancer Therapeutics. 16:1866-1876
Neutropenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC) and we aimed to elucidate the potential mechanism of this toxicity. To investigate whether ADCs affect neutrophil production from bone marrow, an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baab18deca0572d367967394d221806
https://doi.org/10.1158/1535-7163.mct-17-0133
https://doi.org/10.1158/1535-7163.mct-17-0133
Autor:
Pia M. Challita-Eid, Dawn Ratay Lortie, Peng Yang, Arthur B. Raitano, Kendall Morrison, Daniel S. Pereira, Fernando Donate, Karen Morrison, Alla Verlinsky, Linnette Capo, David R. Stover, Ingrid B.J.K. Joseph, Hector Aviña, Wendy Liu, Zili An, Josh Snyder, Joseph D. Abad
Publikováno v:
Molecular Cancer Therapeutics. 15:1301-1310
SLITRK6 is a member of the SLITRK family of neuronal transmembrane proteins that was discovered as a bladder tumor antigen using suppressive subtractive hybridization. Extensive immunohistochemistry showed SLITRK6 to be expressed in multiple epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6630ee1ef62cc75d125ba339ab899a83
https://doi.org/10.1158/1535-7163.mct-15-0570
https://doi.org/10.1158/1535-7163.mct-15-0570
Autor:
Pia M. Challita-Eid, Dawn Ratay Lortie, Daulet Satpayev, Fernando Donate, Yuriy Shostak, Alla Verlinsky, Claudia Guevara, Peng Yang, Banmeet Anand, David R. Stover, Rossana Nadell, Nick Dinh, Zili An, Hector Aviña, Karen Morrison, Ingrid B.J.K. Joseph, Kendall Morrison, Sher Bahadur Karki, Monica Leavitt, Faisal Malik, Wendy Liu, Arthur B. Raitano, Daniel S. Pereira, Linnette Capo
Publikováno v:
Cancer Research. 76:3003-3013
The identification of optimal target antigens on tumor cells is central to the advancement of new antibody-based cancer therapies. We performed suppression subtractive hybridization and identified nectin-4 (PVRL4), a type I transmembrane protein and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868563fe15c4564c7f168742a5b70b58
https://doi.org/10.1158/0008-5472.can-15-1313
https://doi.org/10.1158/0008-5472.can-15-1313
Autor:
Zili An, Linnette Capo, Arthur B. Raitano, Pia M. Challita-Eid, Sher Bahadur Karki, Karen Morrison, Daniel S. Pereira, Rossana Nadell, Ryuichi Moriya, Hector Aviña, Kendall Morrison, Peng Yang, Yuriy Shostak, Fernando Donate, John P. Atkinson, David R. Stover, Ingrid B.J.K. Joseph, Daulet Satpayev, Faisal Malik, Wendy Liu, Jimmy Ou
Publikováno v:
Clinical Cancer Research. 22:1989-1999
Purpose: New cancer-specific antigens are required for the design of novel antibody–drug conjugates (ADC) that deliver tumor-specific and highly potent cytotoxic therapy. Experimental Design: Suppression subtractive hybridization identified ectonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fee1e6856167a6fd671572bcc4da3a1
https://doi.org/10.1158/1078-0432.ccr-15-1542
https://doi.org/10.1158/1078-0432.ccr-15-1542
Autor:
Robert J. Ternansky, Patricia L. Gladstone, Zhuoqi Zhang, Graham Parry, Fernando Donate, Renzhong Fu, Jose Juarez, Amy L. Allan, Jinbao Xiang, Andrew P. Mazar, Xu Bai
Publikováno v:
MedChemComm. 7:1946-1951
An efficient strategy for the discovery of kinase inhibitors by a combination of diversity-oriented synthesis and selective screening is described. Initially, a set of 10 compounds representing a 10-scaffold library of diversity-oriented pyrimidine-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5f7ca18a4f4a40c7af850c56c2e9e9
https://doi.org/10.1039/c6md00351f
https://doi.org/10.1039/c6md00351f
Autor:
Pia M. Challita-Eid, Karen Morrison, Sung-Ju Moon, Rene S. Hubert, Jenny Nater, Peng Yang, Faisal Malik, Josh Snyder, Roland Luethy, Hector Aviña, Jimmy Ou, Brian A. Mendelsohn, Linnette Capo, Sher Karki, Jeffrey O. Coleman, Zhilan Zeng, Hui Zhao, Fernando Donate, Sara Gulesserian, John P. Atkinson, David R. Stover
Publikováno v:
Cancer research. 78(8)
AGS-16C3F is an antibody–drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMAF linker-payload currently in development for treatment of metastatic renal cell carcinoma. AGS-16C3F and other ADC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c949207f10c990a4dcf0537425c22bee
https://pubmed.ncbi.nlm.nih.gov/29382707
https://pubmed.ncbi.nlm.nih.gov/29382707
Autor:
Jon Smythe, Nita Fisher, Simon Joel, Avril Adams, Andrew P. Mazar, Fernando Donate, Sarah A. Lowndes, Suzanne M. Watt, Carolyn Hayward, Mark R. Middleton, Anthony Timms, Steven Reich, Adrian L. Harris
Purpose: Copper chelation reduces the secretion of many angiogenic factors and reduces tumor growth and microvascular density in animal models. ATN-224 is a second-generation analogue of ammonium tetrathiomolybdate. The aim of our phase I study was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1d40dd0b6c91ab78bd554a87e4f3be
https://ora.ox.ac.uk/objects/uuid:3f10ca62-8078-4051-970a-b298796c9cb2
https://ora.ox.ac.uk/objects/uuid:3f10ca62-8078-4051-970a-b298796c9cb2
Publikováno v:
Melanoma Research. 19:350-360
Melanoma cells characteristically produce increased levels of reactive oxygen species (ROS) because of the metal-binding properties of melanin and loss of structural integrity of the melanosome. Agents that deplete gluthathione or inhibit superoxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a11e63eed574be202a072c3d071e636
https://doi.org/10.1097/cmr.0b013e32832c6324
https://doi.org/10.1097/cmr.0b013e32832c6324