Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Fernando Cagide-Fagín"'
Autor:
Eva Gil-Martins, Fernando Cagide-Fagín, Daniel Martins, Ana Borer, Daniel José Barbosa, Carlos Fernandes, Daniel Chavarria, Fernando Remião, Fernanda Borges, Renata Silva
Publikováno v:
Journal of Xenobiotics, Vol 14, Iss 2, Pp 772-797 (2024)
Substituted phenethylamines including 2C (2,5-dimethoxyphenethylamines) and NBOMe (N-(2-methoxybenzyl)phenethylamines) drugs are potent psychoactive substances with little to no knowledge available on their toxicity. In the present in vitro study, we
Externí odkaz:
https://doaj.org/article/2f9e300697654e2f9448cd3de97c0db0
Autor:
Fernando Cagide-Fagín, Ricardo Alonso
Publikováno v:
European Journal of Organic Chemistry. 2010:6741-6747
The synthetic power of the recently developed cascade annulations of β-(hetero)aryl-α-nitro-α,β-enals with the pyrrolidine-derived enamine of 2,2-dimethyl-1,3-dioxan-5-one is demonstrated by the first convergent route to (±)-tetrodotoxin.
Autor:
Ricardo Alonso, Krzysztof Kierus, Luis F. Roa, Marta Fernández-González, Juan Carlos Ortiz-Lara, Lidia Ozores-Viturro, Fernando Cagide-Fagín, Patricia Martínez-Bescos
Publikováno v:
The Journal of Organic Chemistry. 73:3745-3753
(Chemical Equation Presented) The first general methodology for the gram-scale preparation of previously overlooked β-(hetero)aryl-α- nitro-α,β-enals (3) is reported. Condensation of (hetero)aromatic aldehydes with 2-nitroethanol gave the E-isome
Autor:
Hugo Lago-Santomé, Patricia Martínez-Bescos, Ricardo Alonso, Fernando Cagide-Fagín, Lidia Ozores-Viturro, Marta Fernández-González
Publikováno v:
The Journal of organic chemistry. 79(18)
As demonstrated with the β-(2-furyl)-substituted analogue 1b, β-aryl-α-nitro-α,β-enals (1) behave as heterodienes against enamines and enol ethers using their enal unit (e.g., 1b → 12). α-Nitro-α,β-enals can act as well as highly reactive d
Publikováno v:
The Journal of organic chemistry. 77(24)
2-Methoxymethylpyrrolidine best performed, among several other proline derivatives, to control the enantioselective [3+3] annulation of β-(hetero)aryl-α-nitro-α,β-enals with commercial 2,2-dimethyl-1,3-dioxan-5-one, a procedure that renders highl
Autor:
Fernando Cagide-Fagín, Juan Carlos Ortiz-Lara, Olaia Nieto-García, Ricardo Alonso, Hugo Lago-Santomé
Publikováno v:
Organicbiomolecular chemistry. 10(4)
A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (±)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.
Autor:
Ricardo Alonso, Fernando Cagide-Fagín
Publikováno v:
European Journal of Organic Chemistry. 2010
The cover picture shows furfural and dihydroxyacetone, which are two compounds that can be obtained from plant sources, for example, from olive stones and sugar beets, respectively. These compounds can be used as building blocks for a convergent, cas
Autor:
Patricia, Martínez-Bescos, Fernando, Cagide-Fagín, Luis F, Roa, Juan Carlos, Ortiz-Lara, Krzysztof, Kierus, Lidia, Ozores-Viturro, Marta, Fernández-González, Ricardo, Alonso
Publikováno v:
The Journal of organic chemistry. 73(10)
The first general methodology for the gram-scale preparation of previously overlooked beta-(hetero)aryl-alpha-nitro-alpha,beta-enals (3) is reported. Condensation of (hetero)aromatic aldehydes with 2-nitroethanol gave the E-isomers of uncommon beta-(
Publikováno v:
Chemical communications (Cambridge, England). (40)
A novel, highly stereocontrolled formal [3 + 3] annulation of beta-aryl-alpha-nitro-alpha,beta-enals with the enamine derived from 2,2-dimethyl-1,3-dioxan-5-one and pyrrolidine afforded protected nitrocyclitols with five newly created stereocentres a
Publikováno v:
Molecular Cancer Therapeutics. 8:A176-A176
One of the biggest hurdles in the fight against cancer is the non-selective nature of most current treatments. On the other hand, opioids-refractive cancer pain is a most important unsolved problem. Consequently, the search and development of new dru