Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Fernando Bartolome"'
Autor:
Macarena de la Cueva, Desiree Antequera, Lara Ordoñez-Gutierrez, Francisco Wandosell, Antonio Camins, Eva Carro, Fernando Bartolome
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The most accepted hypothesis in Alzheimer’s disease (AD) is the amyloid cascade which establishes that Aβ accumulation may induce the disease development. This accumulation may occur years before the clinical symptoms but it has not been
Externí odkaz:
https://doaj.org/article/c4c788ab38e24e9e93f36d32dcaf83ea
Autor:
Macarena de la Cueva, Desiree Antequera, Lara Ordoñez‑Gutierrez, Francisco Wandosell, Antonio Camins, Eva Carro, Fernando Bartolome
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/c5ea4e6af79f456c8b9034534676f791
Autor:
Fernando Bartolome, Desiree Antequera, Macarena de la Cueva, Marcos Rubio-Fernandez, Nerea Castro, Consuelo Pascual, Antoni Camins, Eva Carro
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background The increasing risk of obesity and diabetes among other metabolic disorders are the consequence of shifts in dietary patterns with high caloric-content food intake. We previously reported that megalin regulates energy homeostasis
Externí odkaz:
https://doaj.org/article/b6d91bb541cb4cc3ae593efacfeebc38
Autor:
Desiree Antequera, Diego Moneo, Laura Carrero, Fernando Bartolome, Isidro Ferrer, Gordon Proctor, Eva Carro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In the last few years, microbial infection and innate immune theories have been proposed as an alternative approach explaining the etiopathogenesis and origin of Alzheimer’s disease (AD). Lactoferrin, one of the main antimicrobial proteins in saliv
Externí odkaz:
https://doaj.org/article/8930d42536224165a53ee10ce32fd053
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1421 (2022)
Oxidative stress (OS) is the result of an imbalance between the production of reactive oxygen species (ROS) and the antioxidant capacity of cells. Due to its high oxygen demand, the human brain is highly susceptible to OS and, thus, it is not a surpr
Externí odkaz:
https://doaj.org/article/cc9aa9bf331c42f1b0065cc4414e2c5f
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract The search for new, robust, and reproducible biomarkers for Alzheimer's disease (AD) diagnosis is a challenge. We recently reported that salivary lactoferrin (Lf) could be presented as new biomarker candidate for AD, being both non‐invasiv
Externí odkaz:
https://doaj.org/article/e1112d776bc549efb6b00cc35a378a68
Autor:
Fernando Bartolome, Macarena de la Cueva, Consuelo Pascual, Desiree Antequera, Tamara Fernandez, Carmen Gil, Ana Martinez, Eva Carro
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-15 (2018)
Abstract Background The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood–brain barrier. We previously found that intraperitoneal treatment with S14 exerted neuroprotection in an
Externí odkaz:
https://doaj.org/article/ce1ff3b247b74aee8a25c73c982e1f23
Autor:
Víctor Antonio Blanco-Palmero, Marcos Rubio-Fernández, Desireé Antequera, Alberto Villarejo-Galende, José Antonio Molina, Isidro Ferrer, Fernando Bartolome, Eva Carro
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1094 (2021)
Neuroinflammation is a common feature in Alzheimer’s (AD) and Parkinson’s (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations
Externí odkaz:
https://doaj.org/article/3ec417ac598c44d58683dbd256fa4a56
Autor:
Fernando Bartolome, Noemi Esteras, Angeles Martin-Requero, Claire Boutoleau-Bretonniere, Martine Vercelletto, Audrey Gabelle, Isabelle Le Ber, Tadashi Honda, Albena T. Dinkova-Kostova, John Hardy, Eva Carro, Andrey Y. Abramov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Abnormal mitochondrial function has been found in patients with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Mutations in the p62 gene (also known as SQSTM1) which encodes the p62 protein have been reported in both
Externí odkaz:
https://doaj.org/article/6c3d41bcb5fa43bfac86e75704ab5618
Autor:
Marta González-Sánchez, Javier Jiménez, Arantzazu Narváez, Desiree Antequera, Sara Llamas-Velasco, Alejandro Herrero-San Martín, Jose Antonio Molina Arjona, Adolfo López de Munain, Alberto Lleó Bisa, M.-Pilar Marco, Montserrat Rodríguez-Núñez, David Andrés Pérez-Martínez, Alberto Villarejo-Galende, Fernando Bartolome, Elena Domínguez, Eva Carro
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 571 (2020)
Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer´s disease (AD). KYNA is primarily produced by astrocytes and is consid
Externí odkaz:
https://doaj.org/article/405350ab088d471c83af58a3ed0faadf