Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5 dynamics depending on its dimerization status

Autor: Fanny Momboisse, Giacomo Nardi, Philippe Colin, Melanie Hery, Nelia Cordeiro, Simon Blachier, Olivier Schwartz, Fernando Arenzana-Seisdedos, Nathalie Sauvonnet, Jean-Christophe Olivo-Marin, Bernard Lagane, Thibault Lagache, Anne Brelot

Publikováno v: eLife, Vol 11 (2022)

G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational and oligomeric states. However, how these states impact GPCRs biological function and therapeutic targeting remains incompletely known. Here, we investigat

Externí odkaz: https://doaj.org/article/6ee4f1070d8b415380bac80983845833

Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands

Autor: Zhicheng Zhou, Isabelle Staropoli, Anne Brelot, Peggy Suzanne, Aurélien Lesnard, Fanny Fontaine, Serge Perato, Sylvain Rault, Olivier Helynck, Fernando Arenzana-Seisdedos, Jana Sopkova-de Oliveira Santos, Bernard Lagane, Hélène Munier-Lehmann, Philippe Colin

Publikováno v: Molecules, Vol 28, Iss 3, p 1156 (2023)

The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers. Here, we identified new CXCR4 ligands in the CERM

Externí odkaz: https://doaj.org/article/2649592c172747d6a3a95d1a2c3b0285

Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis.

Autor: Marie Armani-Tourret, Zhicheng Zhou, Romain Gasser, Isabelle Staropoli, Vincent Cantaloube-Ferrieu, Yann Benureau, Javier Garcia-Perez, Mayte Pérez-Olmeda, Valérie Lorin, Bénédicte Puissant-Lubrano, Lambert Assoumou, Constance Delaugerre, Jean-Daniel Lelièvre, Yves Lévy, Hugo Mouquet, Guillaume Martin-Blondel, Jose Alcami, Fernando Arenzana-Seisdedos, Jacques Izopet, Philippe Colin, Bernard Lagane

Publikováno v: PLoS Pathogens, Vol 17, Iss 4, p e1009526 (2021)

HIV-1 infects CD4 T lymphocytes (CD4TL) through binding the chemokine receptors CCR5 or CXCR4. CXCR4-using viruses are considered more pathogenic, linked to accelerated depletion of CD4TL and progression to AIDS. However, counterexamples to this para

Externí odkaz: https://doaj.org/article/f6a51f49aafc435696f3d3a1a1dc8d6f

CCR5 structural plasticity shapes HIV-1 phenotypic properties.

Autor: Philippe Colin, Zhicheng Zhou, Isabelle Staropoli, Javier Garcia-Perez, Romain Gasser, Marie Armani-Tourret, Yann Benureau, Nuria Gonzalez, Jun Jin, Bridgette J Connell, Stéphanie Raymond, Pierre Delobel, Jacques Izopet, Hugues Lortat-Jacob, Jose Alcami, Fernando Arenzana-Seisdedos, Anne Brelot, Bernard Lagane

Publikováno v: PLoS Pathogens, Vol 14, Iss 12, p e1007432 (2018)

CCR5 plays immune functions and is the coreceptor for R5 HIV-1 strains. It exists in diverse conformations and oligomerization states. We interrogated the significance of the CCR5 structural diversity on HIV-1 infection. We show that envelope glycopr

Externí odkaz: https://doaj.org/article/04c4b9e73bd8406d87eb80a540994e50

The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma

Autor: Fernando Arenzana-Seisdedos, Marcel Spaargaren, Willem Kraan, Hildo Lantermans, Zemin Ren, Annemieke Kuil, S. T. Pals, Marie José Kersten

Publikováno v: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-15 (2021)
Journal of Hematology & Oncology
JOURNAL OF HEMATOLOGY & ONCOLOGY, 14(1):11. BioMed Central

Background The survival and proliferation of multiple myeloma (MM) cells in the bone marrow (BM) critically depend on interaction with stromal cells expressing the chemokine CXCL12. CXCL12 regulates the homing to the BM niche by mediating the transen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83daa0ab2ae047890ced29daead893c1
https://doaj.org/article/6fe651d0fce74e0a8a070beae4ab4b46