Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fernando Alvarez-Nunez"'
Publikováno v:
Advanced Powder Technology. 31:3080-3084
Kushner et al. proposed a scale-up model to describe the effect of lubrication on tablet tensile strength. In our study, a lubricant cohesiveness term, (1 + α/V), was added to the lubrication scale-up model reported by Kushner et al. to address the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68fd9eeabaf0cf7e952d0e4b199c6066
https://doi.org/10.1016/j.apt.2020.04.029
https://doi.org/10.1016/j.apt.2020.04.029
Autor:
Fernando Alvarez-Nunez, Gavin Andrews, J E Huckle, B Khorsand, Dominick Daurio, Chung John Inn, C Lagan, Jeffrey M. Katz
Publikováno v:
AAPS PharmSciTech. 22
Molecular dispersions are a highly effective method of increasing bioavailability for a poorly soluble active pharmaceutical ingredient (API) and can be prepared on a large scale by hot melt extrusion (HME). Processing thermally labile active pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9d7d60605cf899d3619bc2140f980ae
https://doi.org/10.1208/s12249-021-02122-7
https://doi.org/10.1208/s12249-021-02122-7
Autor:
Dominick Daurio, Antonios Zavaliangos, Armen Pirjanian, Jeffrey M. Katz, Michael Johnson, Fernando Alvarez-Nunez
Publikováno v:
Journal of Pharmaceutical Sciences. 106:3604-3612
An approximate solution is presented for the prediction of air entrapment during tableting. Assuming weak coupling of the deformation of the solid phase, the flow of interstitial air and a set of reasonable additional geometric assumptions, the gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619a20269f9bc6c4cdae6fa34a8382f7
https://doi.org/10.1016/j.xphs.2017.09.001
https://doi.org/10.1016/j.xphs.2017.09.001
Publikováno v:
Molecular Pharmaceutics. 10:1949-1957
Understanding the crystallization kinetics of an amorphous drug is critical for the development of an amorphous solid dispersion (ASD) formulation. This paper examines the phase separation and crystallization of the drug AMG 517 in ASDs of varying dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f0a6e6e9fa2439bdf9fb7de5221123
https://doi.org/10.1021/mp300714g
https://doi.org/10.1021/mp300714g
Publikováno v:
Journal of pharmaceutical sciences. 106(3)
The challenge of bringing innovative medicines to patients in combination with intense competition within the pharmaceutical industry has induced companies to develop quality medicines more efficiently and cost-effectively. State-of-the-art approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb7f77c7dcfac327cc041f3e8b2df79
https://pubmed.ncbi.nlm.nih.gov/27915208
https://pubmed.ncbi.nlm.nih.gov/27915208
Publikováno v:
Pharmaceutics, Vol 3, Iss 3, Pp 582-600 (2011)
Pharmaceutics
Pharmaceutics; Volume 3; Issue 3; Pages: 582-600
Pharmaceutics
Pharmaceutics; Volume 3; Issue 3; Pages: 582-600
The application of twin screw extrusion (TSE) as a scalable and green process for the manufacture of cocrystals was investigated. Four model cocrystal forming systems, Caffeine-Oxalic acid, Nicotinamide-trans cinnamic acid, Carbamazepine-Saccharin, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50473bc423eb2648eb067e1b58693ae2
http://www.mdpi.com/1999-4923/3/3/582/
http://www.mdpi.com/1999-4923/3/3/582/
Autor:
Dominick Daurio, Eric J. Munson, Cesar Medina, Fernando Alvarez-Nunez, Janan Jona, Karthik Nagapudi, Jenifer Maclean
Publikováno v:
Journal of Pharmaceutical Sciences. 100:3332-3344
In this paper, we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug Sulindac. Both cryomilling and ball milling of the drug with Neusilin were found to produce the amorphous pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a546ea1c921539c26f4a2578e97394
https://doi.org/10.1002/jps.22583
https://doi.org/10.1002/jps.22583
Publikováno v:
Journal of Pharmaceutical Sciences. 99:1693-1696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4be812d7fc5e9dfbe2bd183911f5d6
https://doi.org/10.1002/jps.21942
https://doi.org/10.1002/jps.21942
Publikováno v:
Journal of Pharmaceutical Sciences. 96:1147-1158
The work presented here was motivated by the premise that the amorphous state serves as a medium to study cocrystal formation. The molecular mobility inherent to amorphous phases can lead to molecular associations between different components such th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57df4ceee6a5855edbeb178a7714ff75
https://doi.org/10.1002/jps.20945
https://doi.org/10.1002/jps.20945
Publikováno v:
Faraday discussions. 170
The application of twin screw extrusion (TSE) in the scale-up of cocrystal production was investigated by using AMG 517–sorbic acid as a model system. Extrusion parameters that influenced conversion to the cocrystal such as temperature, feed rate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1244e7dab5f113307e58d99286e852ee
https://pubmed.ncbi.nlm.nih.gov/25406487
https://pubmed.ncbi.nlm.nih.gov/25406487