Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fernando, Dela Cruz"'
Publikováno v:
Sykepleien. :e-88349
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b52f84489abda7abd4bc45b14c5765c5
https://doi.org/10.4220/sykepleiens.2022.88349
https://doi.org/10.4220/sykepleiens.2022.88349
Autor:
Claire Leurent, Jessica Mancuso, Charles Carrieri, Constantino Kantaridis, Laure Mendes da Costa, Ruolun Qiu, Richann Liu, Terence Fullerton, Jae Eun Ahn, Ping He, Fernando Dela Cruz, Eva Hajos-Korcsok
Publikováno v:
Clinical Pharmacology and Therapeutics
γ-Secretase modulators (GSMs) represent a promising therapy for Alzheimer's disease by reducing pathogenic amyloid-β (Aβ) peptide production. Three phase I studies (NCT02316756, NCT02407353, and NCT02440100) investigated the safety/tolerability, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16619e9beb2c58d9d896f6f3123afafe
https://pubmed.ncbi.nlm.nih.gov/31314925
https://pubmed.ncbi.nlm.nih.gov/31314925
Autor:
Yamin Wang, Manami Tsutsumi, Gretchen Mannelly, Xin Ma, Laurel Sweet, David P. Dickson, Tatiana E. Shelekhin, Kake Zhao, Jian Zhu, Andreas Stolle, Mareli Rodriguez, Stephen J. O'connor, Philip Coish, Helana Hoover-Litty, Mary-Katherine Monahan, Qian Zhao, Chengzhi Zhang, Thomas H. Claus, Fernando Dela Cruz, Ingo Muegge, Mingbao Zhang, Dongping Fan, Derek B. Lowe, Miao Dai, Tindy Li, Lei Zhu, Neil Bifulco, Ming Wang, Hai-Jun Zhang, Bullock William H
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:297-301
A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46128ad1217a6806c1665f707b083755
https://doi.org/10.1016/j.bmcl.2005.10.008
https://doi.org/10.1016/j.bmcl.2005.10.008
Autor:
Stephanie L. Yung, Xianbu Peng, Yin Liang, Hongxing Chen, Fernando Dela Cruz, Ling Yang, Clark Pan, Jian Zhu, James N. Livingston, Thomas H. Claus, Sarah Hamren, Manami Tsutsumi, Yaxin Li
Publikováno v:
Diabetes. 51:1453-1460
Pituitary adenylate cyclase—activating peptide (PACAP) and vasoactive intestinal peptide (VIP) activate two shared receptors, VPAC1 and VPAC2. Activation of VPAC1 has been implicated in elevating glucose output, whereas activation of VPAC2 may be i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9e714eb2b8a748916a7d5971e7b4080
https://doi.org/10.2337/diabetes.51.5.1453
https://doi.org/10.2337/diabetes.51.5.1453
Publikováno v:
Environmental Health Perspectives
Endocrine disruptors are hormone mimics that modify hormonal action in humans and animals. It is thought that some endocrine disruptors modify estrogen and androgen action in humans and animals by suppressing aromatase activity. Aromatase cytochrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7890eb19e5ac8438b12ef62c94a84c
https://doi.org/10.1289/ehp.99107855
https://doi.org/10.1289/ehp.99107855
Autor:
Manami Tsutsumi, Rico C. Lavoie, James N. Livingston, Frederick Ehrgott, Laurel Sweet, Herbert Ogutu, Steve Magnuson, Tatiana E. Shelekhin, Philip Wickens, Jeff Shapiro, Qian Zhao, Robert Schoenleber, Louis-David Cantin, Bullock William H, John Amatruda, Sidney X. Liang, Fernando Dela Cruz, Ellalahewage Kumarasinghe, David Ladner, Thomas H. Claus, Miao Dai, Christopher Town, Chengzhi Zhang, Derek B. Lowe, Martin F. Hentemann, Michael Burns, Sarah Heald, Jeffrey Johnson, Gretchen Mannelly, Susan Pleasic-Williams, Mugge Ingo A, Chih-Yuan Chuang, Dongping Fan, David P. Dickson, Xin Ma, Christiana Iwuagwu
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcd0d05dddd6e859b60d88722dc5ea1
https://pubmed.ncbi.nlm.nih.gov/17601734
https://pubmed.ncbi.nlm.nih.gov/17601734
Autor:
Margit MacDougall, Stephanie L. Yung, Clark Pan, Tracey Todd, Margaret Caudle, Sarah Hamren, Manami Tsutsumi, Shanafelt Armen B, Lynn Lemoine, Fernando Dela Cruz, Steve Roczniak, Jian Zhu, James W. Bloom
Publikováno v:
The Journal of biological chemistry. 278(12)
Pituitary adenylate cyclase-activating peptide (PACAP) has a specific receptor PAC1 and shares two receptors VPAC1 and VPAC2 with vasoactive intestinal peptide (VIP). VPAC2 activation enhances glucose-induced insulin release while VPAC1 activation el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e217f6c467f048d52651a53b8f11b40c
https://pubmed.ncbi.nlm.nih.gov/12525492
https://pubmed.ncbi.nlm.nih.gov/12525492
Autor:
Manami, Tsutsumi, Thomas H, Claus, Yin, Liang, Yaxin, Li, Ling, Yang, Jian, Zhu, Fernando, Dela Cruz, Xianbu, Peng, Hongxing, Chen, Stephanie L, Yung, Sarah, Hamren, James N, Livingston, Clark Q, Pan
Publikováno v:
Diabetes. 51(5)
Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) activate two shared receptors, VPAC1 and VPAC2. Activation of VPAC1 has been implicated in elevating glucose output, whereas activation of VPAC2 may be inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bde22b88490e1db93934510f8c5a4cf
https://pubmed.ncbi.nlm.nih.gov/11978642
https://pubmed.ncbi.nlm.nih.gov/11978642
Autor:
Paul Mak, Fernando Dela Cruz
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 62(4)
Transcriptional activation of the Drosophila ecdysone receptor (EcR) was studied in yeast cells, which carry a reporter plasmid containing the ecdysone response element in the absence or presence of its heterodimeric partners, ultraspiracle protein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ca4efae472591ac6750f4e32e7962c
https://pubmed.ncbi.nlm.nih.gov/9408090
https://pubmed.ncbi.nlm.nih.gov/9408090
