Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.

Autor: Jarvis R; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Josephine Ng SF; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Nathanson AJ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Cardarelli RA; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Abiraman K; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Wade F; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Evans-Strong A; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Fernandez-Campa MP; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Deeb TZ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Smalley JL; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Jamier T; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Gurrell IK; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., McWilliams L; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Kawatkar A; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA., Conway LC; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Wang Q; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Burli RW; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Brandon NJ; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Chessell IP; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Goldman AJ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Maguire JL; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Moss SJ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA; Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1 6BT, UK. Electronic address: stephen.moss@tufts.edu.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Mar 21; Vol. 4 (3), pp. 100957. Date of Electronic Publication: 2023 Mar 07.