Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Fernandez Arias, P."'
Autor:
Marcel S. Woo, Joseph Therriault, Erin M. Jonaitis, Rachael Wilson, Rebecca E. Langhough, Nesrine Rahmouni, Andrea Lessa Benedet, Nicholas J. Ashton, Cécile Tissot, Juan Lantero-Rodriguez, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J. Betthauser, Firoza Z. Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C. Kolb, Andreas Jeromin, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Jesse Klostranec, Paolo Vilali, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Sterling C. Johnson, Pedro Rosa-Neto
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105413- (2024)
Summary: Background: Blood-based disease staging across the Alzheimer's disease (AD) continuum holds the promise to identify individuals that profit from disease-modifying therapies. We set out to identify Braak V+ (Braak V and/or VI) tau PET-positiv
Externí odkaz:
https://doaj.org/article/fb10423af32b4438978a55cda015eda3
Autor:
Yi-Ting Wang, Joseph Therriault, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Jaime Fernandez-Arias, Sulantha S. Mathotaarachchi, Jenna Stevenson, Firoza Z. Lussier, Andréa L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Females represent approximately 70% of the Alzheimer’s disease (AD) cases and the literature has proposed a connection between the decreased estrogen levels during menopause and an increased AD risk. Previous investigations have
Externí odkaz:
https://doaj.org/article/daf9534a01764ab599de980ae7f154aa
Autor:
Julie Ottoy, Min Su Kang, Jazlynn Xiu Min Tan, Lyndon Boone, Reinder Vos de Wael, Bo-yong Park, Gleb Bezgin, Firoza Z. Lussier, Tharick A. Pascoal, Nesrine Rahmouni, Jenna Stevenson, Jaime Fernandez Arias, Joseph Therriault, Seok-Jun Hong, Bojana Stefanovic, JoAnne McLaurin, Jean-Paul Soucy, Serge Gauthier, Boris C. Bernhardt, Sandra E. Black, Pedro Rosa-Neto, Maged Goubran
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Alzheimer’s disease (AD) is a brain network disorder where pathological proteins accumulate through networks and drive cognitive decline. Yet, the role of network connectivity in facilitating this accumulation remains unclear. Using in-viv
Externí odkaz:
https://doaj.org/article/fde529232e944d638ac5830511c20cef
Autor:
Lazaro M. Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Thomas K. Karikari, Nicholas J. Ashton, Andréa L. Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C. Kolb, Pedro Rosa-Neto, Yasser Iturria-Medina
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Neuronal dysfunction and cognitive deterioration in Alzheimer’s disease (AD) are likely caused by multiple pathophysiological factors. However, mechanistic evidence in humans remains scarce, requiring improved non-invasive techniques and i
Externí odkaz:
https://doaj.org/article/d1d394702b194a57a434755661c25a8f
Autor:
Lazaro M. Sanchez-Rodriguez, Ahmed F. Khan, Quadri Adewale, Gleb Bezgin, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Hongxiu Jiang, Xiaoqian Chai, Felix Carbonell, Pedro Rosa-Neto, Yasser Iturria-Medina
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The molecular mechanisms underlying neuronal dysfunction in Alzheimer’s disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and cellular components associated with whole-brain dysregulation caused by amyloid-beta (Aβ)
Externí odkaz:
https://doaj.org/article/1657c77c5c334d1eb95796dc2572b831
Autor:
Clemente F. Arias, Nuno Valente-Leal, Federica Bertocchini, Sofia Marques, Francisco J. Acosta, Cristina Fernandez-Arias
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The regulation of red blood cell (RBC) homeostasis is widely assumed to rely on the control of cell production by erythropoietin (EPO) and the destruction of cells at a fixed, species-specific age. In this work, we show that such a regulator
Externí odkaz:
https://doaj.org/article/5b0e4b7c8f8f4865937e0b8439f2857a
Autor:
Marcel S. Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L. Benedet, Nicholas J. Ashton, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z. Lussier, Thomas K. Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Introduction Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer’s disease (AD). However, synaptic damage happens early in AD at the very early stages of tau accumulation. It remai
Externí odkaz:
https://doaj.org/article/8072bbc5673044c19bd12aa939e0a997
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