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Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

Autor: Dejnirattisai W; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Huo J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Zhou D; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Zahradník J; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Supasa P; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Liu C; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Ginn HM; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Mentzer AJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Tuekprakhon A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Nutalai R; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wang B; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Dijokaite A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Khan S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Avinoam O; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Bahar M; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Skelly D; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Adele S; Peter Medawar Building for Pathogen Research, Oxford, UK., Johnson SA; Peter Medawar Building for Pathogen Research, Oxford, UK., Amini A; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK., Ritter T; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Mason C; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Dold C; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Pan D; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust.; Department of Respiratory Sciences, University of Leicester., Assadi S; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust., Bellass A; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust., Omo-Dare N; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust., Koeckerling D; Medical Sciences Division, University of Oxford., Flaxman A; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Jenkin D; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Voysey M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Clemens SAC; Institute of Global Health, University of Siena, Siena, Brazil; Department of Paediatrics, University of Oxford, Oxford, UK., Naveca FG; Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil., Nascimento V; Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil., Nascimento F; Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil., Fernandes da Costa C; Fundação de Vigilância em Saúde do Amazonas, Manaus, Amazonas, Brazil., Resende PC; Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil., Pauvolid-Correa A; Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil.; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States., Siqueira MM; Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil., Baillie V; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Serafin N; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Ditse Z; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Da Silva K; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Madhi S; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Nunes MC; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Malik T; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK., Openshaw PJ; National Heart & Lung Institute, Imperial College London., Baillie JK; Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, UK., Semple MG; NIHR Health Protection Research Unit, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK., Townsend AR; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Carroll MW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK., Klenerman P; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Barnes E; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Dunachie SJ; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Centre For Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand, Department of Medicine, University of Oxford, Oxford, UK., Constantinides B; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Webster H; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Crook D; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pollard AJ; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Lambe T; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Paterson NG; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Williams MA; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Hall DR; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Mongkolsapaya J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand., Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Schreiber G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Stuart DI; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.; Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK., Screaton GR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Dec 22. Date of Electronic Publication: 2021 Dec 22.