Atividade anticarcinogênica da tributirina associada ou não ao sorafenibe em ratos Fischer-344 implantados com células JM-1

Autor: Fernandes, Laura Helena Gasparini

O carcinoma hepatocelular (HCC) é o sexto mais frequente e a segunda maior causa de mortalidade por câncer no mundo, além de apresentar alta taxa de recidiva. A associação de sorafenibe (SO) com agentes quimiopreventivos representa uma estratég

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/9/9132/tde-26072018-160820/

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.

Autor: Ortega JF; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., de Conti A; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, USA., Tryndyak V; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, USA., Furtado KS; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Heidor R; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Horst MA; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Fernandes LH; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Tavares PE; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Pogribna M; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, USA., Shpyleva S; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, USA., Beland FA; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, USA., Pogribny IP; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, USA., Moreno FS; Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

Publikováno v: Oncotarget [Oncotarget] 2016 Apr 26; Vol. 7 (17), pp. 24339-47.