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Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells
Autor:
Jose Carlos Quilles Junior, Andrei Leitão, Fernanda dos Reis Rocho Carlos, Tracey D. Bradshaw, Viviane W. Mignone, Lyudmila Turyanska, A. Montanari, Maria Augusta Arruda
Publikováno v:
RSC Advances. 9:36699-36706
Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated