Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Fernanda da C. S. Boechat"'
Autor:
Pedro N. Batalha, Luana da S. M. Forezi, Maria Clara R. Freitas, Nathalia M. de C. Tolentino, Ednilsom Orestes, José Walkimar de M. Carneiro, Fernanda da C. S. Boechat, Maria Cecília B. V. de Souza
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 388-400 (2019)
4-Oxoquinolines are a class of organic substances of great importance in medicinal chemistry, due to their biological and synthetic versatility. N-1-Alkylated-4-oxoquinoline derivatives have been associated with different pharmacological activities s
Externí odkaz:
https://doaj.org/article/174efd9380d24ee6ae5eb6dd2df88cae
Autor:
Luana da S. M. Forezi, Nathalia M. C. Tolentino, Alessandra M. T. de Souza, Helena C. Castro, Raquel C. Montenegro, Rafael F. Dantas, Maria E. I. M. Oliveira, Floriano P. Silva, Jr., Leilane H. Barreto, Rommel M. R. Burbano, Bárbara Abrahim-Vieira, Riethe de Oliveira, Vitor F. Ferreira, Anna C. Cunha, Fernanda da C. S. Boechat, Maria Cecília B. V. de Souza
Publikováno v:
Molecules, Vol 19, Iss 5, Pp 6651-6670 (2014)
As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. The inhibitory activity of
Externí odkaz:
https://doaj.org/article/0c0bbe1c1bd842cab0787b03238be42a
Autor:
Izabel C. P. Paixão, José Paulo Gagliardi Leite, Pedro N. Batalha, Robson Ss Marinho, David de O. Silva, Ivson L. Gama, Luana da Sm Forezi, Ana Maria Viana Pinto, Maria C. Β. V. de Souza, Fernanda da C. S. Boechat, Anna C. Cunha, Letícia V. Faro
Publikováno v:
Antiviral Therapy. 25:13-20
Background Bovine herpesvirus type 5 is an important agent of meningoencephalitis in cattle and has been identified in outbreaks of bovine neurological disease in several Brazilian states. In recent years, oxoquinoline derivatives have become an impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c42265df42f842b5f3d79026a3c08bf
https://doi.org/10.3851/imp3329
https://doi.org/10.3851/imp3329
Autor:
Ana T. P. C. Gomes, Adelaide Almeida, Maria A. F. Faustino, Maria G. P. M. S. Neves, Fernanda S. Sagrillo, Alan Gonçalves de Souza, Fernanda da C. S. Boechat, José A. S. Cavaleiro, Cristina Dias, Maria Cecília B. V. de Souza, Amanda Rodrigues Pinto Costa
Publikováno v:
Photochemical & Photobiological Sciences. 18:1910-1922
New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301e10685be30e585546fb78ae418553
https://doi.org/10.1039/c9pp00102f
https://doi.org/10.1039/c9pp00102f
Autor:
Fernanda da C. S. Boechat, Thiago Mota do Vale, Maria Cecília B. V. de Souza, Joice Cristina de Oliveira Andrade, Pedro N. Batalha
Publikováno v:
Anais do II Congresso Brasileiro de Ciências Farmacêuticas On-line.
Introdução: As quinolonocarboxamidas são substâncias orgânicas, derivadas das 4-oxoquinolinas, muito utilizadas na química medicinal. Com o desenvolvimento dos estudos frente aos derivados quinolonocarboxamídicos, observou-se que 25% dos medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::827c6754d53e8427be9cb8a4f332862a
https://doi.org/10.51161/rems/775
https://doi.org/10.51161/rems/775
Autor:
Amanda Rodrigues Pinto Costa, Fernanda da C. S. Boechat, Anna C. Cunha, Mauro Sola-Penna, Ricardo Imbroisi Filho, Patricia Zancan, Angélica Lauria Nascimento Mello, Vinícius R. Campos, Fernanda S. Sagrillo, Alan Gonçalves de Souza, Maria Cecília B. V. de Souza
Publikováno v:
Life sciences. 276
Aims AMPK plays a critical role regulating cell metabolism, growth and survival. Interfering with this enzyme activity has been extensively studied as putative mechanism for cancer therapy. The present work aims to identify a specific AMPK activator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0a963447fa15d84149aa52925bc7c4
https://pubmed.ncbi.nlm.nih.gov/33831423
https://pubmed.ncbi.nlm.nih.gov/33831423
Autor:
Pedro N. Batalha, Nanci C. L. Garden, Karine N. de Andrade, Rodolfo I. Teixeira, José Walkimar de M. Carneiro, Maria Cecília B. V. de Souza, Amanda Rodrigues Pinto Costa, Fernanda da C. S. Boechat, Micaeli L. da S. Moreira, Rodolfo G. Fiorot
Publikováno v:
Anais do VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular.
4-quinolones derivatives can present fluorescent properties, depending on their substituents and on the chemical environment (e.g., acidic medium), allowing their application as ion sensors. We theoretically evaluated the photophysical properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c8f3aa066636cc3262918ea32d328e4
https://doi.org/10.21826/viiiseedmol202006
https://doi.org/10.21826/viiiseedmol202006
Autor:
Fernando de C. da Silva, Eduardo Caio Torres-Santos, Anna C. Cunha, Valter Viana Andrade-Neto, Gabrieli B. R. Goncalves, Vanessa G. Oliveira, Maria Cecília B. V. de Souza, Viviane dos Santos Faiões, Miriam F. O. Lima, Fernanda da C. S. Boechat
Publikováno v:
Current Topics in Medicinal Chemistry. 18:1454-1464
Background: Leishmaniasis is a neglected public health problem caused by several protozoanspecies of the genus Leishmania. The therapeutic arsenal for treating leishmaniasis is quite limited, raising concerns about the occurrence of resistant strains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7772e569499a6c811b451c41413ed1d2
https://doi.org/10.2174/1568026618666181002110116
https://doi.org/10.2174/1568026618666181002110116
Autor:
Maria Cecília B. V. de Souza, Fernanda da C. S. Boechat, Vanessa G. Oliveira, Luana da S. M. Forezi, Pedro N. Batalha, Nathalia M. C. Tolentino, Fernanda S. Sagrillo
Publikováno v:
Current topics in medicinal chemistry. 20(3)
4-Oxoquinoline derivatives constitute an important family of biologically important substances, associated with different bioactivities, which can be synthesized by different synthetic methods, allowing the design and preparation of libraries of subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c450ade1aeb3ab4479916c953fa4c5bd
https://pubmed.ncbi.nlm.nih.gov/31995008
https://pubmed.ncbi.nlm.nih.gov/31995008