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Autor:
Taciane Cristina Fernandes Pedrosa, Fernanda Segurasse de Moraes, Maria Silvia Gurgel Assis, Jacqueline de Souza, Gislaine Ribeiro Pereira, Tamires Guedes Caldeira, André Luís Morais Ruela
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1557-1571
Acyclovir is an antiviral drug poorly absorbed in the gastrointestinal tract due to its hydrophilicity, with low oral bioavailability (~20%). Although acyclovir is prescribed in the management of herpes simplex encephalitis (HSE), the disease has a p