Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Fernanda Schreiber"'
Publikováno v:
Cells, Vol 13, Iss 6, p 477 (2024)
The gut mucosal epithelium is one of the largest organs in the body and plays a critical role in regulating the crosstalk between the resident microbiome and the host. To this effect, the tight control of what is permitted through this barrier is of
Externí odkaz:
https://doaj.org/article/047723ef42ec4129af16e7be9717e89e
Autor:
Christoph J Blohmke, Julius Muller, Malick M Gibani, Hazel Dobinson, Sonu Shrestha, Soumya Perinparajah, Celina Jin, Harri Hughes, Luke Blackwell, Sabina Dongol, Abhilasha Karkey, Fernanda Schreiber, Derek Pickard, Buddha Basnyat, Gordon Dougan, Stephen Baker, Andrew J Pollard, Thomas C Darton
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
Abstract Misdiagnosis of enteric fever is a major global health problem, resulting in patient mismanagement, antimicrobial misuse and inaccurate disease burden estimates. Applying a machine learning algorithm to host gene expression profiles, we iden
Externí odkaz:
https://doaj.org/article/7ea3698836af4155880bcbcd299c5d0e
Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever
Autor:
Christoph J. Blohmke, Jennifer Hill, Thomas C. Darton, Matheus Carvalho-Burger, Andrew Eustace, Claire Jones, Fernanda Schreiber, Martin R. Goodier, Gordon Dougan, Helder I. Nakaya, Andrew J. Pollard
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The mechanisms by which oral, live-attenuated vaccines protect against typhoid fever are poorly understood. Here, we analyze transcriptional responses after vaccination with Ty21a or vaccine candidate, M01ZH09. Alterations in response profiles were r
Externí odkaz:
https://doaj.org/article/b15ed62d9906441bb070cfd2f40524dd
Autor:
Olusegun Oshota, Max Conway, Maria Fookes, Fernanda Schreiber, Roy R Chaudhuri, Lu Yu, Fiona J E Morgan, Simon Clare, Jyoti Choudhary, Nicholas R Thomson, Pietro Lio, Duncan J Maskell, Pietro Mastroeni, Andrew J Grant
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181365 (2017)
Salmonella enterica are a threat to public health. Current vaccines are not fully effective. The ability to grow in infected tissues within phagocytes is required for S. enterica virulence in systemic disease. As the infection progresses the bacteria
Externí odkaz:
https://doaj.org/article/1d9cfdd9b41d4e28b88fa68324407829
Autor:
Glen P. Carter, Anjana Chakravorty, Tu Anh Pham Nguyen, Steven Mileto, Fernanda Schreiber, Lucy Li, Pauline Howarth, Simon Clare, Bliss Cunningham, Susan P. Sambol, Adam Cheknis, Iris Figueroa, Stuart Johnson, Dale Gerding, Julian I. Rood, Gordon Dougan, Trevor D. Lawley, Dena Lyras
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Clostridium difficile is a leading cause of antibiotic-associated diarrhea, a significant animal pathogen, and a worldwide public health burden. Most disease-causing strains secrete two exotoxins, TcdA and TcdB, which are considered to be th
Externí odkaz:
https://doaj.org/article/b47764f906484de9a05ec4ef6bf39866
Autor:
Trevor D Lawley, Simon Clare, Alan W Walker, Mark D Stares, Thomas R Connor, Claire Raisen, David Goulding, Roland Rad, Fernanda Schreiber, Cordelia Brandt, Laura J Deakin, Derek J Pickard, Sylvia H Duncan, Harry J Flint, Taane G Clark, Julian Parkhill, Gordon Dougan
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002995 (2012)
Relapsing C. difficile disease in humans is linked to a pathological imbalance within the intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that mice infected with epidemic C. difficile (genotype 027/BI) develop highly
Externí odkaz:
https://doaj.org/article/e29efcffca5d4832924a324b0e3c1a00
Autor:
Miguel Reina Ortiz, Fernanda Schreiber, Susana Benitez, Nely Broncano, Martha E Chico, Maritza Vaca, Neal Alexander, David J Lewis, Gordon Dougan, Philip J Cooper
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1157 (2011)
Chronic soil-transmitted helminth (STH) infections are associated with effects on systemic immune responses that could be caused by alterations in immune homeostasis. To investigate this, we measured the impact in children of STH infections on cytoki
Externí odkaz:
https://doaj.org/article/b7b2cc848d4346f7aa8a8b861f3d8716
Autor:
Anne-Francoise Petavy, Carlos Hormaeche, Samia Lahmar, Hammou Ouhelli, Alejandro Chabalgoity, Thierry Marchal, Samira Azzouz, Fernanda Schreiber, Gabriela Alvite, Marie-Elisabeth Sarciron, Duncan Maskell, Adriana Esteves, Georges Bosquet
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 2, Iss 1, p e125 (2008)
Dogs are the main source of human cystic echinococcosis. An oral vaccine would be an important contribution to control programs in endemic countries. We conducted two parallel experimental trials in Morocco and Tunisia of a new oral vaccine candidate
Externí odkaz:
https://doaj.org/article/bfb539c897d742cb933b39d82bdc6f42
Autor:
Rhys A. Dunstan, David Goulding, Joshua M. Hardy, Claire Cormie, Fasséli Coulibaly, Fuyi Li, Sam Dougan, Derek Pickard, Katherine Harcourt, Gordon Dougan, Rhys Grinter, Fernanda Schreiber, Jyoti S. Choudhary, Lu Yu, Richard A. Strugnell, Trevor Lithgow, Simon Clare, Jiangning Song
Publikováno v:
Molecular Microbiology. 112:1831-1846
The discovery of a Salmonella-targeting phage from the waterways of the United Kingdom provided an opportunity to address the mechanism by which Chi-like bacteriophage (phage) engages with bacterial flagellae. The long tail fibre seen on Chi-like pha
Autor:
María A. Duque-Correa, Matthew Berriman, Ruby White, Faye H. Rodgers, Richard K. Grencis, David Goulding, Amy H. Buck, Sally Forrest, Fernanda Schreiber
Publikováno v:
International Journal for Parasitology
Duque-Correa, M A, Schreiber, F, Rodgers, F H, Goulding, D, Forrest, S, White, R, Buck, A, Grencis, R K & Berriman, M 2020, ' Development of caecaloids to study host–pathogen interactions : new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum ', International Journal For Parasitology, vol. 50, no. 9, pp. 707-718 . https://doi.org/10.1016/j.ijpara.2020.06.001
Duque-Correa, M A, Schreiber, F, Rodgers, F H, Goulding, D, Forrest, S, White, R, Buck, A, Grencis, R K & Berriman, M 2020, ' Development of caecaloids to study host–pathogen interactions : new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum ', International Journal For Parasitology, vol. 50, no. 9, pp. 707-718 . https://doi.org/10.1016/j.ijpara.2020.06.001
Graphical abstract
Highlights • Development of new methods to generate, culture and characterise mouse caecaloids is described. • Caecaloids recapitulate the caecal epithelium composition and spatial organisation. • Caecaloids can be used
Highlights • Development of new methods to generate, culture and characterise mouse caecaloids is described. • Caecaloids recapitulate the caecal epithelium composition and spatial organisation. • Caecaloids can be used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf5b66c311fe20db91025352d51ad12
https://doi.org/10.1101/2020.05.11.087684
https://doi.org/10.1101/2020.05.11.087684