Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fernanda S. Sagrillo"'
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 69 (2019)
Duvelisib (Copiktra®) is a dual inhibitor of phosphoinositide 3-kinases (PI3Kδ and PI3Kγ). In 2018, duvelisib was first approved by the Food and Drug Administration (FDA) for the treatment of adult patients with relapsed or refractory chronic lymp
Externí odkaz:
https://doaj.org/article/0a4c3a45171f4b0f9fcd2ebb3b7fcee2
Autor:
Maria Laura Bolognesi, Fernanda S. Sagrillo, Carlos A. M. Fraga, Daniel Alencar Rodrigues, Pedro de Sena Murteira Pinheiro
Publikováno v:
Medicinal Research Reviews. 40:2177-2211
Despite the applicability of histone deacetylase inhibitors (HDACis) for cancer treatment, several works in the literature have shown that these inhibitors can be used in several other diseases, such as neurodegenerative diseases (NDs). This review b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8069efbd69d327dacaab9e321d6482a5
https://doi.org/10.1002/med.21701
https://doi.org/10.1002/med.21701
Autor:
Marina Amaral Alves, Carlos A. M. Fraga, Patricia Dias Fernandes, Pedro de Sena Murteira Pinheiro, Carlos Mauricio R. Sant'Anna, Fernanda S. Sagrillo, Daniel Alencar Rodrigues, Sreekanth Thota, Fabiana Sélos Guerra, Lorrane S. Chaves
Publikováno v:
ChemMedChem. 15:539-551
Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacological profile, and molecular modeling of a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaf213aecc07520225239a0f628f6d3
https://doi.org/10.1002/cmdc.201900716
https://doi.org/10.1002/cmdc.201900716
Autor:
Luzineide W. Tinoco, Pedro de Sena Murteira Pinheiro, Carlos A. M. Fraga, Carlos Mauricio R. Sant'Anna, Marina Amaral Alves, Alviclér Magalhães, Fernanda S. Sagrillo, Maria Clara R. Freitas, Sreekanth Thota, Daniel Alencar Rodrigues
Publikováno v:
New Journal of Chemistry. 44:10994-11005
Conformational stabilization mediated by hydrogen bonds can play an important role in the drug-target recognition process. Non-classical hydrogen bonding is receiving great attention, where C–H⋯Y hydrogen bonds are found in some biological system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e72464bfdae76ac7b927eaee1d27dcdb
https://doi.org/10.1039/d0nj01598a
https://doi.org/10.1039/d0nj01598a
Autor:
Ana T. P. C. Gomes, Adelaide Almeida, Maria A. F. Faustino, Maria G. P. M. S. Neves, Fernanda S. Sagrillo, Alan Gonçalves de Souza, Fernanda da C. S. Boechat, José A. S. Cavaleiro, Cristina Dias, Maria Cecília B. V. de Souza, Amanda Rodrigues Pinto Costa
Publikováno v:
Photochemical & Photobiological Sciences. 18:1910-1922
New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301e10685be30e585546fb78ae418553
https://doi.org/10.1039/c9pp00102f
https://doi.org/10.1039/c9pp00102f
Autor:
Amanda Rodrigues Pinto Costa, Fernanda da C. S. Boechat, Anna C. Cunha, Mauro Sola-Penna, Ricardo Imbroisi Filho, Patricia Zancan, Angélica Lauria Nascimento Mello, Vinícius R. Campos, Fernanda S. Sagrillo, Alan Gonçalves de Souza, Maria Cecília B. V. de Souza
Publikováno v:
Life sciences. 276
Aims AMPK plays a critical role regulating cell metabolism, growth and survival. Interfering with this enzyme activity has been extensively studied as putative mechanism for cancer therapy. The present work aims to identify a specific AMPK activator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0a963447fa15d84149aa52925bc7c4
https://pubmed.ncbi.nlm.nih.gov/33831423
https://pubmed.ncbi.nlm.nih.gov/33831423
Autor:
Maria Cecília B. V. de Souza, Fernanda da C. S. Boechat, Vanessa G. Oliveira, Luana da S. M. Forezi, Pedro N. Batalha, Nathalia M. C. Tolentino, Fernanda S. Sagrillo
Publikováno v:
Current topics in medicinal chemistry. 20(3)
4-Oxoquinoline derivatives constitute an important family of biologically important substances, associated with different bioactivities, which can be synthesized by different synthetic methods, allowing the design and preparation of libraries of subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c450ade1aeb3ab4479916c953fa4c5bd
https://pubmed.ncbi.nlm.nih.gov/31995008
https://pubmed.ncbi.nlm.nih.gov/31995008
Autor:
Luana da S. M. Forezi, Thiago Moreno L. Souza, Leonardo Brozeguini, Anna C. Cunha, Fernanda da C. S. Boechat, Fernanda S. Sagrillo, Carolina Q. Sacramento, Christiane M. Nogueira, Maria Cecília B. V. de Souza, Isakelly P. Marques, Vitor F. Ferreira, Cecília S. Riscado, Osvaldo A. Santos-Filho, Letícia V. Faro, Natalia Fintelman-Rodrigues
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7777-7784
We described the synthesis of a new congener series of 1,2,3-triazolyl-4-oxoquinolines and evaluated their ability to inhibit oseltamivir (OST)-resistant influenza strains. Oxoquinoline derivative 1i was the most potent compound within this series, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c117a7e4f7c186f1cf79887fb0ef9e
https://doi.org/10.1016/j.bmc.2015.11.028
https://doi.org/10.1016/j.bmc.2015.11.028
Autor:
Luiza Fernandes, Fernando L. Palhano, Marcela Cristina de Moraes, Jeffery W. Kelly, Luciana Romão, Debora Foguel, Fernanda S. Sagrillo, Nathalia Lopes de Moraes, Augusto Vieira Magalhães, Neil P. Grimster
Publikováno v:
ACS chemical neuroscience. 8(8)
Protein aggregation is a hallmark of several neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. It has been shown that lysine residues play a key role in the formation of these aggregates. Thus, the ability to disrupt agg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04891242c181935a4e879b07e7896689
https://pubmed.ncbi.nlm.nih.gov/28425704
https://pubmed.ncbi.nlm.nih.gov/28425704
Publikováno v:
Revista Virtual de Química. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f9182bcaf7e35f0f21a06b9f0da0020
https://doi.org/10.5935/1984-6835.20140034
https://doi.org/10.5935/1984-6835.20140034