Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fernanda Rodríguez-Enríquez"'
Autor:
Elías Quezada, Fernanda Rodríguez-Enríquez, Reyes Laguna, Elena Cutrín, Francisco Otero, Eugenio Uriarte, Dolores Viña
Publikováno v:
Molecules, Vol 26, Iss 15, p 4550 (2021)
Neurodegenerative diseases have a complex nature which highlights the need for multitarget ligands to address the complementary pathways involved in these diseases. Over the last decade, many innovative curcumin-based compounds have been designed and
Externí odkaz:
https://doaj.org/article/375c2797111d4f3bb03896b9966ea350
Publikováno v:
ChemMedChem. 16:179-186
This study explores the potential of 7-amidocoumarins as multitarget agents against Parkinson's and Alzheimer's diseases, by modulating the substitution patterns within the scaffold. Sixteen compounds were synthesized via 7-amino-4-methylcoumarin acy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e46dd088f05445f0f3dc9dce3010b99
https://doi.org/10.1002/cmdc.202000454
https://doi.org/10.1002/cmdc.202000454
The authors have requested that this preprint be removed from Research Square.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98a31451502a88a58f4f98e24b2f980
https://doi.org/10.21203/rs.3.rs-226609/v1
https://doi.org/10.21203/rs.3.rs-226609/v1
Autor:
Fernanda Rodríguez-Enríquez, José Angel Fontenla, Maria João Matos, Dolores Viña, Eugenio Uriarte
Publikováno v:
Bioorganic chemistry. 101
Monoamine oxidase B (MAO-B) inhibitors are still receiving great attention as promising therapeutic agents for central nervous system disorders. This study explores, for the first time, the potential of 3-thiophenylcoumarins as in vitro and in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4ee51258e2b2777eef225d35b112e6
https://pubmed.ncbi.nlm.nih.gov/32569895
https://pubmed.ncbi.nlm.nih.gov/32569895
Autor:
Mattia Sturlese, Pedro Besada, Elias Quezada, Miguel Alonso-Pena, Stefano Moro, Carmen Terán, Dolores Viña, María Carmen Costas-Lago, Fernanda Rodríguez-Enríquez, José Angel Fontenla, Iria Torres-Terán
The 3-pyridazinylcoumarin scaffold was previously reported as an efficient core for the discovery of reversible and selective inhibitors of MAO-B, a validated drug target for PD therapy which also plays an important role in the AD progress. Looking f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b018afc28f64a976fb7e7a10bc968
http://hdl.handle.net/11577/3349054
http://hdl.handle.net/11577/3349054
Autor:
Maria João Matos, María Isabel Rodríguez-Franco, Fernanda Borges, Fernanda Rodríguez-Enríquez, Dolores Viña, Lourdes Santana, Reyes Laguna, Eugenio Uriarte, Martín Estrada
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Monoamine oxidase (MAO) generates reactive oxygen species (ROS), which cause neuronal cell death, causing neurodegeneration. Agents that are able to concurrently inhibit MAO and scavenge free radicals represent promising multifunctional neuroprotecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad006f4094b1a413d62bae4bb9c687b
https://doi.org/10.1002/cmdc.201500408
https://doi.org/10.1002/cmdc.201500408
Autor:
Carmen Terán, Pedro Besada, Fernanda Borges, Fernanda Rodríguez-Enríquez, Dolores Viña, Santiago Vilar, Eugenio Uriarte, María Carmen Costas-Lago
Publikováno v:
European journal of medicinal chemistry. 139
Compounds of hybrid structure pyridazine-coumarin were discovered as potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B). These compounds were synthesized in good yield following a multistep approach based on Knoevenagel reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06ac60fadbff39e1895100c8846ab9e
https://pubmed.ncbi.nlm.nih.gov/28797881
https://pubmed.ncbi.nlm.nih.gov/28797881
Autor:
Santiago Vilar, Maria João Matos, Martín Estrada, Lourdes Santana, María Isabel Rodríguez-Franco, George Hripcsak, Dolores Viña, Fernanda Rodríguez-Enríquez, Eugenio Uriarte
Publikováno v:
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and selectivity profile against the hMAO-B isoform (IC50 values between 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60002d50a50a00f19db60d9c3b138e44
http://hdl.handle.net/10347/23489
http://hdl.handle.net/10347/23489