Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Fernanda Ledda"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Glucocorticoids (GC) affect neuronal plasticity, development and function of the nervous system by inhibiting neurotrophin-induced Trk signaling. It has been established that pretreatment with dexamethasone (DEX) restricts Neurotrophin-induced neurit
Externí odkaz:
https://doaj.org/article/71bc8880bd7b4cafa3c44f5b14824e0a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
In the mammalian adult hippocampus, new neurons are continuously generated throughout life in the subgranular zone of the dentate gyrus. Increasing evidence point out the contribution of adult-born hippocampal granule cells (GCs) to cognitive process
Externí odkaz:
https://doaj.org/article/d3f18daa6da7437f8c48773a0e89fa7a
Autor:
Antonela Bonafina, Mariela Fernanda Trinchero, Antonella Soledad Ríos, Pedro Bekinschtein, Alejandro Fabián Schinder, Gustavo Paratcha, Fernanda Ledda
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4308-4319.e4 (2019)
Summary: The glial cell line-derived neurotrophic factor (GDNF) is required for the survival and differentiation of diverse neuronal populations during nervous system development. Despite the high expression of GDNF and its receptor GFRα1 in the adu
Externí odkaz:
https://doaj.org/article/81a619b4e96743deac7657507358d50e
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1000-1015 (2018)
Summary: The balance between factors leading to proliferation and differentiation of cortical neural precursors (CNPs) determines the correct cortical development. In this work, we show that GDNF and its receptor GFRα1 are expressed in the neocortex
Externí odkaz:
https://doaj.org/article/3b581f224acb45439eb8e2af510056db
Autor:
Mariela F. Trinchero, Karina A. Buttner, Jessica N. Sulkes Cuevas, Silvio G. Temprana, Paula A. Fontanet, M. Cristina Monzón-Salinas, Fernanda Ledda, Gustavo Paratcha, Alejandro F. Schinder
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1129-1139 (2017)
Summary: During aging, the brain undergoes changes that impair cognitive capacity and circuit plasticity, including a marked decrease in production of adult-born hippocampal neurons. It is unclear whether development and integration of those new neur
Externí odkaz:
https://doaj.org/article/7038ccca8ce948268e0b06a8c37ddeb1
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. Recent advances established that BDNF function is cont
Externí odkaz:
https://doaj.org/article/96020f81514043f399ae32ece649039b
Autor:
Fernanda Ledda, Gustavo Paratcha
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Proper function of the nervous system critically relies on sophisticated neuronal networks interconnected in a highly specific pattern. The architecture of these connections arises from sequential developmental steps such as axonal growth and guidanc
Externí odkaz:
https://doaj.org/article/9638673c3209442ba0b98688a60d5ba1
Autor:
Fernanda Ledda, Gustavo Paratcha
Publikováno v:
Biomarker Insights, Vol 2, Pp 45-58 (2007)
ophic factors control cellular physiology by activating specific receptor tyrosine kinases (RTKs). While the over activation of RTK signaling pathways is associated with cell growth and cancer, recent findings support the concept that impaired down-r
Externí odkaz:
https://doaj.org/article/2a6f7f35bbfc40838e6cf5e4b6d8f2f1
Autor:
Fernando C Alsina, Dolores Irala, Paula A Fontanet, Francisco J Hita, Fernanda Ledda, Gustavo Paratcha
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32087 (2012)
The Sprouty (Spry) family of proteins represents endogenous regulators of downstream signaling pathways induced by receptor tyrosine kinases (RTKs). Using real time PCR, we detect a significant increase in the expression of Spry4 mRNA in response to
Externí odkaz:
https://doaj.org/article/26f08dc99e1e46218f686c5a1c274ebe
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9647 (2010)
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally
Externí odkaz:
https://doaj.org/article/db6504eea6b64e5db94498c085c5832e