Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Fernanda I. Saldívar-González"'
Autor:
Daniela Gaytán-Hernández, Ana L. Chávez-Hernández, Edgar López-López, Jazmín Miranda-Salas, Fernanda I. Saldívar-González, José L. Medina-Franco
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Science and art have been connected for centuries. With the development of new computational methods, new scientific disciplines have emerged, such as computational chemistry, and related fields, such as cheminformatics. Chemoinformatics is
Externí odkaz:
https://doaj.org/article/8ec83d6460cb4dcc9149f1500fa31534
Autor:
Diana L. Prado-Romero, Fernanda I. Saldívar-González, Iván López-Mata, Pedro A. Laurel-García, Adrián Durán-Vargas, Enrique García-Hernández, Norberto Sánchez-Cruz, José L. Medina-Franco
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 775 (2024)
Designing and developing inhibitors against the epigenetic target DNA methyltransferase (DNMT) is an attractive strategy in epigenetic drug discovery. DNMT1 is one of the epigenetic enzymes with significant clinical relevance. Structure-based de novo
Externí odkaz:
https://doaj.org/article/bc2952031d3843e5ac94fd48ed862e5a
Autor:
Diana L. Prado-Romero, Alejandro Gómez-García, Raziel Cedillo-González, Hassan Villegas-Quintero, Juan F. Avellaneda-Tamayo, Edgar López-López, Fernanda I. Saldívar-González, Ana L. Chávez-Hernández, José L. Medina-Franco
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
The structure-activity relationships data available in public databases of inhibitors of DNA methyltransferases (DNMTs), families of epigenetic targets, plus the structural information of DNMT1, enables the development of a robust structure-based dru
Externí odkaz:
https://doaj.org/article/90d7767f95e34a71acfbb84a93692c68
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Virtual small molecule libraries are valuable resources for identifying bioactive compounds in virtual screening campaigns and improving the quality of libraries in terms of physicochemical properties, complexity, and structural diversity. In this co
Externí odkaz:
https://doaj.org/article/2b54f544693f4534b5e0302881cd3529
Publikováno v:
Journal of Cheminformatics, Vol 12, Iss 1, Pp 1-25 (2020)
Abstract Virtual compound libraries are increasingly being used in computer-assisted drug discovery applications and have led to numerous successful cases. This paper aims to examine the fundamental concepts of library design and describe how to enum
Externí odkaz:
https://doaj.org/article/7d8efe66f56d431da0540b7951ff0bdd
Autor:
Ana L. Chávez-Hernández, K. Eurídice Juárez-Mercado, Fernanda I. Saldívar-González, José L. Medina-Franco
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1805 (2021)
Acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV) continues to be a public health problem. In 2020, 680,000 people died from HIV-related causes, and 1.5 million people were infected. Antiretrovirals are a way
Externí odkaz:
https://doaj.org/article/ec8682d1c358467cba5c8fce420f9e19
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1566 (2020)
Natural products have a significant role in drug discovery. Natural products have distinctive chemical structures that have contributed to identifying and developing drugs for different therapeutic areas. Moreover, natural products are significant so
Externí odkaz:
https://doaj.org/article/9589ae8d6f1844daaa2cad95fbb099a0
Autor:
Fernanda I. Saldívar-González, Alejandro Gómez-García, David E. Chávez-Ponce de León, Norberto Sánchez-Cruz, Javier Ruiz-Rios, B. Angélica Pilón-Jiménez, José L. Medina-Franco
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Naturally occurring small molecules include a large variety of natural products from different sources that have confirmed activity against epigenetic targets. In this work we review chemoinformatic, molecular modeling, and other computational approa
Externí odkaz:
https://doaj.org/article/3a59442af8764669a375f69018c9246a
Autor:
B. Angélica Pilón-Jiménez, Fernanda I. Saldívar-González, Bárbara I. Díaz-Eufracio, José L. Medina-Franco
Publikováno v:
Biomolecules, Vol 9, Iss 1, p 31 (2019)
Compound databases of natural products have a major impact on drug discovery projects and other areas of research. The number of databases in the public domain with compounds with natural origins is increasing. Several countries, Brazil, France, Pana
Externí odkaz:
https://doaj.org/article/657fe17ddcbd4b31929caab66874d114
Autor:
José J. Naveja-Romero, Fernanda I. Saldívar-González, Diana L. Prado-Romero, Angel J. Ruiz-Moreno, Marco Velasco-Velázquez, Ramón Alain Miranda-Quintana, José L. Medina-Franco
The manuscript discusses recent advances on computer-aided drug discovery (CADD) with focus on data-dependent drug discovery. Herein, we do not intend to review the many CADD methodologies comprehensively. Instead, the review discusses progress on se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a08a0829038d75bd03e57ab6616448b
https://doi.org/10.26434/chemrxiv-2022-9t2rj
https://doi.org/10.26434/chemrxiv-2022-9t2rj
