Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Fernanda G Kugeratski"'
Publikováno v:
eLife, Vol 12 (2024)
Non-invasive early cancer diagnosis remains challenging due to the low sensitivity and specificity of current diagnostic approaches. Exosomes are membrane-bound nanovesicles secreted by all cells that contain DNA, RNA, and proteins that are represent
Externí odkaz:
https://doaj.org/article/6ad4462a788a4de2b100f4457763f564
Autor:
Fernanda G Kugeratski, Michel Batista, Alexandre Haruo Inoue, Bruno Dias Ramos, Marco Aurelio Krieger, Fabricio K Marchini/
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 110, Iss 5, Pp 687-690 (2015)
The functional characterisation of thousands of Trypanosoma cruzi genes remains a challenge. Reverse genetics approaches compatible with high-throughput cloning strategies can provide the tool needed to tackle this challenge. We previously published
Externí odkaz:
https://doaj.org/article/32a07c7f3d834be29ca2e0c068284e9d
Autor:
Alvaro Román-Fernández, Mohammed A. Mansour, Fernanda G. Kugeratski, Jayanthi Anand, Emma Sandilands, Laura Galbraith, Kai Rakovic, Eva C. Freckmann, Erin M. Cumming, Ji Park, Konstantina Nikolatou, Sergio Lilla, Robin Shaw, David Strachan, Susan Mason, Rachana Patel, Lynn McGarry, Archana Katoch, Kirsteen J. Campbell, Colin Nixon, Crispin J. Miller, Hing Y. Leung, John Le Quesne, James C. Norman, Sara Zanivan, Karen Blyth, David M. Bryant
Publikováno v:
Science Advances. 9
The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a791c833e168aa5e23e18018b0fa92b6
https://doi.org/10.1126/sciadv.abq1858
https://doi.org/10.1126/sciadv.abq1858
Autor:
Alvaro Román-Fernández, Mohammed A. Mansour, Fernanda G. Kugeratski, Jayanthi Anand, Emma Sandilands, Laura Galbraith, Kai Rakovic, Eva C. Freckmann, Erin M. Cumming, Ji Park, Konstantina Nikolatou, Sergio Lilla, Robin Shaw, David Strachan, Susan Mason, Rachana Patel, Lynn McGarry, Archana Katoch, Kirsteen J. Campbell, Colin Nixon, Crispin J. Miller, Hing Y. Leung, John Le Quesne, James C. Norman, Sara Zanivan, Karen Blyth, David M. Bryant
The glycocalyx component and sialomucin Podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27a470245b09741fa61bbe3076726f6c
https://doi.org/10.1101/2022.11.04.515043
https://doi.org/10.1101/2022.11.04.515043
Publikováno v:
Science Signaling. 15
Blood vessels deliver oxygen and nutrients that sustain tumor growth and enable the dissemination of cancer cells to distant sites and the recruitment of intratumoral immune cells. In addition, the structural and functional abnormalities of the tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340cfe28e1cf1e440f39b3c96b5ebd2b
https://doi.org/10.1126/scisignal.aaz4742
https://doi.org/10.1126/scisignal.aaz4742
Autor:
Fernanda G. Kugeratski, Raghu Kalluri, Sergio Lilla, Kathleen M. McAndrews, Xunian Zhou, Rosa F. Hwang, Kelly Hodge, Sara Zanivan
Publikováno v:
Nat Cell Biol
Exosomes are extracellular vesicles derived from the endosomal compartment with potential involvement in intercellular communication. We found that frequently used biomarkers of exosomes are heterogeneous and do not exhibit universal utility across d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c848bdad53220455af74fa1371136f
https://doi.org/10.1038/s41556-021-00693-y
https://doi.org/10.1038/s41556-021-00693-y
Autor:
Raghu Kalluri, Valerie S. LeBleu, Kathleen M. McAndrews, Antonios Chronopoulos, Fei Xiao, Fernanda G. Kugeratski
Publikováno v:
Life Science Alliance
This work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy.
CRISPR/Cas9 is a promising technology for gene editing. To date, intracel
CRISPR/Cas9 is a promising technology for gene editing. To date, intracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209affa13f3fa4fa2814dd0371dbb7e8
http://europepmc.org/articles/PMC8321670
http://europepmc.org/articles/PMC8321670
Autor:
Raghu Kalluri, Fernanda G. Kugeratski
Publikováno v:
FEBS J
Exosomes are nanosized extracellular vesicles of endosomal origin that enclose a multitude of functional biomolecules. Exosomes have emerged as key players of intercellular communication in physiological and pathological conditions. In cancer, depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aa32d08b3406cf35a33ab5f182fff8
https://pubmed.ncbi.nlm.nih.gov/32910536
https://pubmed.ncbi.nlm.nih.gov/32910536
Autor:
Guangchun Han, Deborah A. Ledesma, Wenbin Liu, Jeffrey E. Lee, Michael T. Tetzlaff, Christine N. Spencer, Michael A. Davies, Vancheswaran Gopalakrishnan, Oscar Krijgsman, Daniel S. Peeper, Reetakshi Arora, Christian U. Blank, James P. Allison, Catherine Sautès-Fridman, Roberta Zapassodi, Sangeetha M. Reddy, Alexander J. Lazar, Raghu Kalluri, Wolf H. Fridman, Hao Zhao, Lisa H. Butterfield, Keren Yizhak, Lauren E. Haydu, Elisa A. Rozeman, Jennifer A. Wargo, Pierre Olivier Gaudreau, Fernanda G. Kugeratski, Alexandre Reuben, Valerie S. LeBleu, Jianjun Gao, Rafet Basar, Beth A. Helmink, Emily Z. Keung, Hussein Abdul-Hassan Tawbi, Padmanee Sharma, Alex P. Cogdill, Linghua Wang, Disha Rao, Kevin M. McBride, Patrick Hwu, Ton N. Schumacher, Monika A. Zelazowska, Elizabeth M. Burton, Rodabe N. Amaria, Moshe Sade-Feldman, Florent Petitprez, Sapna Pradyuman Patel, Yuanxin Xi, Anthony Lucci, Nir Hacohen, Jorge Blando, Shaojun Zhang, Katayoun Rezvani, Rohit Thakur, Scott E. Woodman, SuFey Ong, Michael Bailey, Sarah Warren, Courtney W. Hudgens, Jeffrey E. Gershenwald
Publikováno v:
Nature
Nature, Nature Publishing Group, 2020, 577 (7791), pp.549-555. ⟨10.1038/s41586-019-1922-8⟩
Nature, vol 577, iss 7791
Nature, Nature Publishing Group, 2020, 577 (7791), pp.549-555. ⟨10.1038/s41586-019-1922-8⟩
Nature, vol 577, iss 7791
Multiomic profiling of several cohorts of patients treated with immune checkpoint blockade highlights the presence and potential role of B cells and tertiary lymphoid structures in promoting therapy response.Treatment with immune checkpoint blockade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be208e7a5506de19270310bdcd5f46c7
https://hal.sorbonne-universite.fr/hal-02456277
https://hal.sorbonne-universite.fr/hal-02456277
Autor:
Juliana Carolina Amorim, Fernanda G. Kugeratski, Aline Castro Rodrigues Lucena, Michel Batista, Fabricio K Marchini, Carla V. de Paula Lima
Publikováno v:
Methods in Molecular Biology ISBN: 9781071602935
Trypanosoma cruzi is a pathogenic protozoan that still has an impact on public health, despite the decrease in the number of infection cases along the years. T. cruzi possesses an heteroxenic life cycle in which it differentiates in at least four for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b11326a7f4535636646f51ae2f1b6ebb
https://doi.org/10.1007/978-1-0716-0294-2_11
https://doi.org/10.1007/978-1-0716-0294-2_11