Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Fernanda Faião Flores"'
Autor:
Fernanda Faião Flores
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
O melanoma maligno é a forma mais agressiva dos tumores cutâneos. Sendo o responsável por mais de 75% das mortes relativas á este tipo de câncer. O principal quimioterápico utilizado no tratamento do melanoma é a dacarbazina (DTIC), entretanto
Publikováno v:
Melanoma Management, Vol 6, Iss 4 (2019)
Externí odkaz:
https://doaj.org/article/a3514644635e46a19b8e30ebb1a8a84d
Autor:
Sathya Neelature Sriramareddy, Fernanda Faião-Flores, Michael F. Emmons, Biswarup Saha, Srikumar Chellappan, Clayton Wyatt, Inna Smalley, Jonathan D. Licht, Michael A. Durante, J. William Harbour, Keiran S. M. Smalley
Publikováno v:
Cancer Gene Therapy. 29:1840-1846
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e8ba06a0c07b47a2b0cb4333a0f3b42
https://doi.org/10.1038/s41417-022-00452-7
https://doi.org/10.1038/s41417-022-00452-7
Autor:
Keiran S.M. Smalley, J. William Harbour, Jonathan D. Licht, Uwe Rix, Silvya Stuchi Maria-Engler, Srikumar P. Chellappan, John M. Koomen, Bin Fang, Biswarup Saha, Fumi Kinose, Michael A. Durante, Michael F. Emmons, Fernanda Faião-Flores
Purpose:The clinical use of MEK inhibitors in uveal melanoma is limited by the rapid acquisition of resistance. This study has used multiomics approaches and drug screens to identify the pan-HDAC inhibitor panobinostat as an effective strategy to lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a6c9d3938006c6153d7b74edfa41ea
https://doi.org/10.1158/1078-0432.c.6528053
https://doi.org/10.1158/1078-0432.c.6528053
Autor:
Keiran S.M. Smalley, J. William Harbour, Jonathan D. Licht, Uwe Rix, Silvya Stuchi Maria-Engler, Srikumar P. Chellappan, John M. Koomen, Bin Fang, Biswarup Saha, Fumi Kinose, Michael A. Durante, Michael F. Emmons, Fernanda Faião-Flores
Supplementary Table S1- Antibodies used for protein expression in western blotting experiments Supplementary Table S2 - Assays used for gene expression in RT-qPCR experiments Supplementary Table S3 - Antibodies used for protein expression in immunofl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b6fa70918d2735b28b48bcd1f4dcb8
https://doi.org/10.1158/1078-0432.22471898
https://doi.org/10.1158/1078-0432.22471898
Autor:
Keiran S.M. Smalley, J. William Harbour, Jonathan D. Licht, Uwe Rix, Silvya Stuchi Maria-Engler, Srikumar P. Chellappan, John M. Koomen, Bin Fang, Biswarup Saha, Fumi Kinose, Michael A. Durante, Michael F. Emmons, Fernanda Faião-Flores
Supplemental Figure 1: Gene ontology network analysis of uveal melanoma cells following MEKi treatment (24h) and ABPP. Supplemental Figure 2: ET-3 increases nuclear accumulation of YAP in 92.1, Mel270, MP41 and OMM1 cells. Supplemental Figure 3: ET-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7b3c2c75bdf283a97ad482de2b351d
https://doi.org/10.1158/1078-0432.22471901
https://doi.org/10.1158/1078-0432.22471901
Autor:
Keiran S.M. Smalley, Jonathan D. Licht, Lixin Wan, Eric K. Lau, Yian A. Chen, John M. Koomen, Vernon K. Sondak, Edward Seto, Dirk Schadendorf, Jurgen C. Becker, Jane L. Messina, Ram Thapa, Ritin Sharma, Fernanda Faião-Flores, Michael F. Emmons
Melanoma cells have the ability to switch to a dedifferentiated, invasive phenotype in response to multiple stimuli. Here, we show that exposure of melanomas to multiple stresses including BRAF–MEK inhibitor therapy, hypoxia, and UV irradiation lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5da52b92a487e5dcfb81b8d1851fac0d
https://doi.org/10.1158/0008-5472.c.6510969.v1
https://doi.org/10.1158/0008-5472.c.6510969.v1
Autor:
Keiran S.M. Smalley, Jonathan D. Licht, Lixin Wan, Eric K. Lau, Yian A. Chen, John M. Koomen, Vernon K. Sondak, Edward Seto, Dirk Schadendorf, Jurgen C. Becker, Jane L. Messina, Ram Thapa, Ritin Sharma, Fernanda Faião-Flores, Michael F. Emmons
Supplementary Table 1: Clinical data on samples stained for HDAC8 expression. S1) HDAC expression levels in melanoma cells S2) Cell lines that are resistant to BRAF inhibitors have upregulated c-Jun protein expression S3) Inhibiting HDAC6 does not re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6ffdbbb57cbf9a3fbf4aae51306ce3
https://doi.org/10.1158/0008-5472.22421604
https://doi.org/10.1158/0008-5472.22421604
Autor:
Tania Marcourakis, Mariana Sayuri Berto Udo, Silvya Stuchi Maria-Engler, Mariana A. da Silva, Leandro Ferreira Dal'Jovem, Sara de Souza Prates, Stephanie de Oliveira Duro, Fernanda Faião-Flores, Raphael Caio Tamborelli Garcia
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Crack cocaine users are simultaneously exposed to volatilized cocaine and to its main pyrolysis product, anhydroecgonine methyl ester (AEME). Although the neurotoxic effects of cocaine have been extensively studied, little is known about AEME or its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d637dfbae4cfa40f9f583c31ce2939e3
https://doi.org/10.1007/s00204-021-03017-z
https://doi.org/10.1007/s00204-021-03017-z
Autor:
Silvya Stuchi Maria-Engler, Sandra Coccuzzo Sampaio, José A. Quincoces, Luciana de Araújo Pimenta, Nayane de Souza, Fernanda Faião-Flores, Erica Aparecida de Oliveira
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Background: Melanoma is the most aggressive skin cancer, and BRAF (V600E) is the most frequent mutation that led to the development of BRAF inhibitors (BRAFi). However, patients treated with BRAFi usually present recidivism after 6-9 months. Curcumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3742198b223ce4b740b08284808bec
https://doi.org/10.2174/1871520620666200218111422
https://doi.org/10.2174/1871520620666200218111422