Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Fernanda Dos Reis, Rocho"'
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Akademický článek
Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.
Autor: Lorenzo Cianni, Carina Lemke, Erik Gilberg, Christian Feldmann, Fabiana Rosini, Fernanda Dos Reis Rocho, Jean F R Ribeiro, Daiane Y Tezuka, Carla D Lopes, Sérgio de Albuquerque, Jürgen Bajorath, Stefan Laufer, Andrei Leitão, Michael Gütschow, Carlos A Montanari
Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0007755 (2020)
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map it
Externí odkaz: https://doaj.org/article/3510716dcbcc410e83482bb1244acca6
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2
Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations
Autor: Fernanda dos Reis Rocho, Jerônimo Lameira, Carlos A. Montanari, Andrei Leitão, Vinícius Bonatto, Anwar Shamim, F. Javier Luque
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Covalent inhibitors are assuming central importance in drug discovery projects, especially in this pandemic scenario. Many research groups have focused their attention on inhibiting viral proteases or human proteases such as cathepsin L (hCatL). The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e79f519132be470dcbfd7afc86772fd
https://pubmed.ncbi.nlm.nih.gov/34460252
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4
Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells
Autor: Jose Carlos Quilles Junior, Andrei Leitão, Fernanda dos Reis Rocho Carlos, Tracey D. Bradshaw, Viviane W. Mignone, Lyudmila Turyanska, A. Montanari, Maria Augusta Arruda
Publikováno v: RSC Advances. 9:36699-36706
Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61228f33402913582d11843a051e2ade
https://doi.org/10.1039/c9ra07161j
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5
Nitrile-based peptoids as cysteine protease inhibitors
Autor: Fernanda dos Reis Rocho, Luana de Fátima Alves, Andrei Leitão, Deborah Yara Alves Cursino dos Santos, Rodrigo Cendron, Carlos A. Montanari, Thiago Kelvin Brito Matos
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Peptidomimetics of the class of dipeptidyl nitrile analog peptoids were synthesized as inhibitors of mammalian cysteine proteases of the papain superfamily. The dipeptidyl nitrile side chains were attached to the peptide backbone's nitrogen atom, not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc60ee25fe0b20160745e5f1ada0149
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6
Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB
Autor: Pedro Henrique Jatai Batista, Carlos A. Montanari, Nicholas Pearce, Barrie Kellam, Andrei Leitão, Daniela De Vita, Thiago Kelvin Brito Matos, Fernanda dos Reis Rocho
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cysteine protease B (CPB) can be targeted by reversible covalent inhibitors that could serve as antileishmanial compounds. Here, sixteen dipeptidyl nitrile derivatives were synthesized, tested against CPB, and analyzed using matched molecular pairs t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5dcb1d8b764a925b438499e87dec1d
https://pubmed.ncbi.nlm.nih.gov/32717373
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7
N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S. In silico design, synthesis and biochemical characterization
Autor: Jürgen Bajorath, Carlos A. Montanari, Jiafei Yin, Michael Gütschow, Carina Lemke, Christian Feldmann, Daniela De Vita, Fernanda dos Reis Rocho, Lorenzo Cianni, Erik Gilberg, Ulrike Bartz
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
A library of cathepsin S inhibitors of the dipeptide nitrile chemotype, bearing a bioisosteric sulfonamide moiety, was synthesized. Kinetic investigations were performed at four human cysteine proteases, i.e. cathepsins S, B, K and L. Compound 12 wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee2526b3b5bca0ed211a7033399460d
http://hdl.handle.net/11573/1477075
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8
Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor
Autor: Peter W. Kenny, Carlos A. Montanari, Chan Li, Lorenzo Cianni, Andrei Leitão, Fabiana Rosini, Thomas G. Warwick, Daniela De Vita, Felipe Cardoso Prado Martins, Fernanda dos Reis Rocho, Jerônimo Lameira, Jonas Emsley, Jean F. R. Ribeiro
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Leishmania mexicana is an obligate intracellular protozoan parasite that causes the cutaneous form of leishmaniasis affecting South America and Mexico. The cysteine protease LmCPB is essential for the virulence of the parasite and therefore, it is an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5019188afe7cc3adfa809277522931ce
http://hdl.handle.net/11573/1477070
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9
Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents
Autor: Sérgio de Albuquerque, Christian Feldmann, Carla D. Lopes, Erik Gilberg, Jean F. R. Ribeiro, Fabiana Rosini, Andrei Leitão, Stefan Laufer, Carina Lemke, Lorenzo Cianni, Michael Gütschow, Jürgen Bajorath, Daiane Y. Tezuka, Carlos A. Montanari, Fernanda dos Reis Rocho
Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0007755 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfec629b9cbe1226217c69826b410da
https://doi.org/10.1101/760736
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10
Organometallic Gold(III) Complex [Au(Hdamp)(L1
Autor: Carla Duque, Lopes, Bruna, Possato, Ana Paula S, Gaspari, Ronaldo J, Oliveira, Ulrich, Abram, José P A, Almeida, Fernanda Dos Reis, Rocho, Andrei, Leitão, Carlos A, Montanari, Pedro I S, Maia, João S, da Silva, Sérgio, de Albuquerque, Zumira A, Carneiro
Publikováno v: ACS infectious diseases. 5(10)
Chagas disease remains a serious public health concern with unsatisfactory treatment outcomes due to strain-specific drug resistance and various side effects. To identify new therapeutic drugs against
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c99b06146963611e1e7302330fa8a57e
https://pubmed.ncbi.nlm.nih.gov/31419384
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