Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Fernanda D. Botelho"'
1
Akademický článek
Frentizole derivatives with mTOR inhibiting and senomorphic properties
Autor: Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys, Adam Skarka, Jelena Dumanovic, Zoran Milovanovic, Vesna Jacevic, Marketa Chvojkova, Kristina Holubova, Karel Vales, Veronika Skoupilova, Marian Valko, Klaudia Jomova, Suliman Y. Alomar, Fernanda D. Botelho, Tanos C.C. Franca, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova
Publikováno v: Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115600- (2023)
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s br
Externí odkaz: https://doaj.org/article/44e7104b724844208bfcb788fd0917db
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3
Akademický článek
Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors
Autor: Fernanda D. Botelho, Marcelo C. dos Santos, Arlan da S. Gonçalves, Kamil Kuca, Martin Valis, Steven R. LaPlante, Tanos C. C. França, Joyce S. F. D. de Almeida
Publikováno v: Toxins, Vol 12, Iss 12, p 746 (2020)
Ricin is a toxin found in the castor seeds and listed as a chemical weapon by the Chemical Weapons Convention (CWC) due to its high toxicity combined with the easiness of obtention and lack of available antidotes. The relatively frequent episodes of
Externí odkaz: https://doaj.org/article/e02b97d00108497e9dff1fdbc46e04d0
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8
Searching for potential drugs against SARS-CoV-2 through virtual screening on several molecular targets
Autor: Felipe Rodrigues de Souza, Steven R. LaPlante, Joyce S. F. D. Almeida, Fernanda D. Botelho, Erick B. F. Galante, Marcelo C. dos Santos, Monique Cardozo, Raphael S. F. Silva, Juliana de Oliveira Carneiro Brum, Eugenie Nepovimova, Kamil Kuca, Mariana de Oliveira Tonelli Nogueira, Rodrigo L. B. Rodrigues, Daniel A. S. Kitagawa, Tanos C. C. França, Leandro A. Vieira, Samir F. de A. Cavalcante, Arlan da Silva Gonçalves, Priscila Ivo Rubim de Santana, Leonardo da Costa Bastos
Publikováno v: Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record
Journal of Biomolecular Structure and Dynamics
The acute respiratory syndrome caused by the SARS-CoV-2, known as COVID-19, has been ruthlessly tormenting the world population for more than six months. However, so far no effective drug or vaccine against this plague have emerged yet, despite the h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552ce5bd775f9580d9d745e83927f672
https://doi.org/10.1080/07391102.2020.1869096
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9
Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok)
Autor: Marcelo C. Santos, Fernanda D. Botelho, Arlan S. Gonçalves, Kamil Kuca, Eugenie Nepovimova, Samir F.A. Cavalcante, Antonio L.S. Lima, Tanos C.C. França
Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 165
The nerve agents of the A-series are relatively recent chemical weapons with no antidote available yet. Once inside the human body, those chemicals act similarly to the classic nerve agents, by binding to the catalytic residue Serine 203 (Ser203) of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6712fdf1cf746add3c55c6f150c5406a
https://pubmed.ncbi.nlm.nih.gov/35489467
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10
Identification of novel potential ricin inhibitors by virtual screening, molecular docking, molecular dynamics and MM-PBSA calculations: a drug repurposing approach
Autor: Joyce S. F. D. de Almeida, Tanos C. C. França, Fernanda D. Botelho, Marcelo C. dos Santos, Arlan da Silva Gonçalves, Steven R. LaPlante
Publikováno v: Journal of biomolecular structuredynamics. 40(12)
Ricin is a potent cytotoxin with no available antidote. Its catalytic subunit, RTA, damages the ribosomal RNA (rRNA) of eukaryotic cells, preventing protein synthesis and eventually leading to cell death. The combination between easiness of obtention
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6760b57a0de9bf8435ee83cae9675646
https://pubmed.ncbi.nlm.nih.gov/33410376
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