Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Fernanda Calheta Vieira Portaro"'
Autor:
Carlos Alberto-Silva, Brenda Rufino da Silva, Julio Cezar Araujo da Silva, Felipe Assumpção da Cunha e Silva, Roberto Tadashi Kodama, Wilmar Dias da Silva, Maricilia Silva Costa, Fernanda Calheta Vieira Portaro
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 931 (2024)
Introduction. The proline-rich decapeptide 10c (Bj-PRO-10c; ENWPHPQIPP) from the Bothrops jararaca snake modulates argininosuccinate synthetase (AsS) activity to stimulate L-arginine metabolite production and neuroprotection in the SH-SY5Y cell line.
Externí odkaz:
https://doaj.org/article/d77ba269d255466886100020b047923b
Autor:
Lucas Yuri Saladini, Marcos Jorge Magalhães-Junior, Cristiane Castilho Fernandes da Silva, Priscila Gonçalves Coutinho Oliveira, Roberto Tadashi Kodama, Lais Gomes, Milton Yutaka Nishiyama-Jr, Patrick Jack Spencer, Wilmar Dias da Silva, Fernanda Calheta Vieira Portaro
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5181 (2024)
Snakebite accidents, neglected tropical diseases per the WHO, pose a significant public health threat due to their severity and frequency. Envenomation by Bothrops genus snakes leads to severe manifestations due to proteolytic enzymes. While the anti
Externí odkaz:
https://doaj.org/article/a025de9c610243a3b862f150a2153a38
Autor:
Felipe Raimondi Guidolin, Kemily Stephanie de Godoi, Angela Alice Amadeu Megale, Cristiane Castilho Fernandes da Silva, Roberto Tadashi Kodama, Daniela Cajado-Carvalho, Leo Kei Iwai, Patrick Jack Spencer, Fernanda Calheta Vieira Portaro, Wilmar Dias da Silva
Publikováno v:
Toxins, Vol 15, Iss 9, p 584 (2023)
Accidents with snakes are responsible for about 32,000 deaths annually in sub-Saharan Africa, caused mostly by snakes from the genus Bitis, in particular Bitis arietans. B. arietans venom is composed of a complex mixture of toxins, mainly metalloprot
Externí odkaz:
https://doaj.org/article/0e60d8ffdb78430f90d2ff59203e729d
Autor:
Daniella dos Santos Courrol, Cristiane Castilho Fernandes da Silva, Luan Gavião Prado, Rosa Maria Chura-Chambi, Ligia Morganti, Gisele Oliveira de Souza, Marcos Bryan Heinemann, Lourdes Isaac, Fernando Paiva Conte, Fernanda Calheta Vieira Portaro, Rodrigo Nunes Rodrigues-da-Silva, Angela Silva Barbosa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Extracellular proteolytic enzymes are produced by a variety of pathogenic microorganisms, and contribute to host colonization by modulating virulence. Here, we present a first characterization of leptolysin, a Leptospira metalloprotease of the pappal
Externí odkaz:
https://doaj.org/article/5f3e9449c46e49a3a9fcf9065da85cae
Autor:
Kemily Stephanie de Godoi, Felipe Raimondi Guidolin, Fernanda Calheta Vieira Portaro, Patrick Jack Spencer, Wilmar Dias da Silva
Publikováno v:
Toxins, Vol 15, Iss 4, p 264 (2023)
Bitis arietans is a medically important snake found in Sub-Saharan Africa. The envenomation is characterized by local and systemic effects, and the lack of antivenoms aggravates the treatment. This study aimed to identify venom toxins and develop ant
Externí odkaz:
https://doaj.org/article/79a087c8001e4116b6ed9655e388f7ef
Autor:
Wilmar Dias da Silva, Sonia A. De Andrade, Ângela Alice Amadeu Megale, Daniel Alexandre De Souza, Osvaldo Augusto Sant’Anna, Fábio Carlos Magnoli, Felipe Raimondi Guidolin, Kemily Stephanie Godoi, Lucas Yuri Saladini, Patrick Jack Spencer, Fernanda Calheta Vieira Portaro
Publikováno v:
Toxins, Vol 14, Iss 9, p 606 (2022)
Snakebite envenomation is considered a neglected tropical disease, affecting tens of thousands of people each year. The recommended treatment is the use of antivenom, which is composed of immunoglobulins or immunoglobulin fragments obtained from the
Externí odkaz:
https://doaj.org/article/605280e763be432dbf575c5f3d970262
Autor:
Carlos Alberto-Silva, Fernanda Calheta Vieira Portaro, Roberto Tadashi Kodama, Halyne Queiroz Pantaleão, Marisa Rangel, Ken-ichi Nihei, Katsuhiro Konno
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021)
Abstract Background Solitary wasp venoms may be a rich source of neuroactive substances, since their venoms are used for paralyzing preys. We have been exploring bioactive constituents of solitary wasp venoms and, in this study, the component profile
Externí odkaz:
https://doaj.org/article/7810f13e60dd4e9fb2b3f2b07adaa076
Autor:
Roberto Tadashi Kodama, Alexandre Kazuo Kuniyoshi, Cristiane Castilho Fernandes da Silva, Daniela Cajado-Carvalho, Bruno Duzzi, Douglas Ceolin Mariano, Daniel C. Pimenta, Rafael Borges, Wilmar Dias da Silva, Fernanda Calheta Vieira Portaro
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)
Abstract Background: Proteases play an important role for the proper physiological functions of the most diverse organisms. When unregulated, they are associated with several pathologies. Therefore, proteases have become potential therapeutic targets
Externí odkaz:
https://doaj.org/article/e855e045556240998a15b01bc1d05636
Autor:
Débora do Carmo Linhares, Fernanda Faria, Roberto Tadashi Kodama, Adriane Michele Xavier Prado Amorim, Fernanda Calheta Vieira Portaro, Dilza Trevisan-Silva, Karla Fernanda Ferraz, Ana Marisa Chudzinski-Tavassi
Publikováno v:
Toxins, Vol 13, Iss 12, p 857 (2021)
Cathepsin L (CatL) is a lysosomal cysteine protease primarily involved in the terminal degradation of intracellular and endocytosed proteins. More specifically, in humans, CatL has been implicated in cancer progression and metastasis, as well as coro
Externí odkaz:
https://doaj.org/article/5bcbd687115f43b08c3921ac238fa275
Autor:
Carlos Alberto-Silva, Fernanda Calheta Vieira Portaro, Roberto Tadashi Kodama, Halyne Queiroz Pantaleão, Hidetoshi Inagaki, Ken-ichi Nihei, Katsuhiro Konno
Publikováno v:
Toxins, Vol 13, Iss 12, p 885 (2021)
Venoms of solitary wasps are utilized for prey capture (insects and spiders), paralyzing them with a stinger injection to be offered as food for their larvae. Thus, the identification and characterization of the components of solitary wasp venoms can
Externí odkaz:
https://doaj.org/article/b456a7161a784c988a133193e893e9f6