Výsledky vyhledávání - "Fernanda C.P. Mesquita"

Restoring anatomical complexity of a left ventricle wall as a step toward bioengineering a human heart with human induced pluripotent stem cell-derived cardiac cells

Autor: Camila Hochman-Mendez, Fernanda C.P. Mesquita, Jacquelynn Morrissey, Ernesto Curty da Costa, Jorn Hulsmann, Karis Tang-Quan, Yutao Xi, Po-Feng Lee, Luiz C. Sampaio, Doris A. Taylor

Publikováno v: Acta Biomaterialia. 141:48-58

The heart is a highly complex, multicellular solid organ with energy-demanding processes that require a dense vascular network, extensive cell-cell interactions, and extracellular matrix (ECM)-mediated crosstalk among heterogeneous cell populations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2081914491f8128cd884bef6989903c
https://doi.org/10.1016/j.actbio.2021.12.016

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Decellularized Extracellular Matrix Powder Accelerates Metabolic Maturation at Early Stages of Cardiac Differentiation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Autor: Fernanda C.P. Mesquita, Jacquelynn Morrissey, Gustavo Monnerat, Gilberto B. Domont, Fabio C. S. Nogueira, Camila Hochman-Mendez

Publikováno v: Cells Tissues Organs. 212:32-44

During fetal development, cardiomyocytes switch from glycolysis to oxidative metabolism to sustain the energy requirements of functional cells. State-of-the-art cardiac differentiation protocols yield phenotypically immature cardiomyocytes, and commo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c261b465461b7cfede61eaca8f62e83
https://doi.org/10.1159/000521580

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Cues from human atrial extracellular matrix enrich the atrial differentiation of human induced pluripotent stem cell-derived cardiomyocytes

Autor: Jacquelynn Morrissey, Gilberto B. Domont, Po-Feng Lee, Fábio C. S. Nogueira, Camila Hochman-Mendez, Yutao Xi, Doris A. Taylor, Fernanda C.P. Mesquita, Luiz C. Sampaio, Helen Andersson, Gustavo Monnerat

Publikováno v: Biomaterials Science. 9:3737-3749

New robust and reproducible differentiation approaches are needed to generate induced pluripotent stem cell (iPSC)-derived cardiomyocytes of specific subtypes in predictable quantities for tissue-specific disease modeling, tissue engineering, and eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b324ce21dcea0819eccafa76b79e68a3
https://doi.org/10.1039/d0bm01686a

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Characterization of perfusion decellularized whole animal body, isolated organs, and multi‐organ systems for tissue engineering applications

Autor: Hassan Virk, Fernanda C.P. Mesquita, Katrina Rhett, Osman E. Rodriguez, Stefan M. Kren, Lourdes Chacon-Alberty, Jacquelynn Morrissey, Camila Hochman-Mendez, Doris A. Taylor, Matthew J. Robertson, Ernesto C da Costa, Luiz C. Sampaio

Publikováno v: Physiological Reports

To expand the application of perfusion decellularization beyond isolated single organs, we used the native vasculature of adult and neonatal rats to systemically decellularize the organs of a whole animal in situ. Acellular scaffolds were generated f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29f2fc071c5b72a5a08cda276e6f615
https://doi.org/10.14814/phy2.14817

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Strategies for iPSC expansion

Autor: Doris A. Taylor, Camila Hochman-Mendez, Fernanda C.P. Mesquita

Establishment of expansion systems that are synthetic, defined, and stable will help accelerate the translation of human pluripotent stem cells (hPSCs). This chapter describes strategies to eliminate feeder cell layer systems for PSC expansion based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f60c4a412954537fd834e138beb082c4
https://doi.org/10.1016/b978-0-12-822231-7.00001-1

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Recommendations for nomenclature and definition of cell products intended for human cardiovascular use

Autor: Mariana Gonzalez Del Hierro, Roberto Bolli, Phillip C. Yang, Emerson C. Perin, Doris A. Taylor, Ray F. Ebert, Joshua M. Hare, Michael P. Murphy, Lourdes Chacon-Alberty, Keith L. March, Rachel W. Vojvodic, Fernanda C.P. Mesquita, Jay H. Traverse, Luiz C. Sampaio, Carl J. Pepine, Timothy D. Henry

Publikováno v: Cardiovasc Res

Exogenous cell-based therapy has emerged as a promising new strategy to facilitate repair of hearts damaged by acute or chronic injury. However, the field of cell-based therapy is handicapped by the lack of standardized definitions and terminology, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7763a67e2a353898b0b77761d8a370
https://pubmed.ncbi.nlm.nih.gov/34387303

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Abstract 549: Characterization of Mesenchymal Stromal Cell-derived Exosomes From Patients With Improved Function Outcome After Ischemic Cardiomyopathy: A Biorepository Evaluation of the Focus-CCTRN Trial

Autor: Lourdes I Chacon, Doris A. Taylor, Hassan Virk, Camila Hochman-Mendez, Fernanda C.P. Mesquita

Publikováno v: Circulation Research. 127

Mesenchymal stromal cells derived from bone marrow (BM-MSCs) have been considered promisingcandidates for regenerative medicine therapies for more than 20 years, but to date cardiovascular clinicaltrials of MSC-based therapies have demonstrated only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac5f44e85c5536eed3aeec5ea868cefc
https://doi.org/10.1161/res.127.suppl_1.549

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Abstract 281: Human Atrial Extracellular Matrix Drives Differentiation of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Toward an Atrial Phenotype

Autor: Gustavo Monnerat, Yutao Xi, Fernanda C.P. Mesquita, Doris A. Taylor, Luiz C. Sampaio, Camila Hochman-Mendez, Jacquelynn Morrissey, Fábio C. S. Nogueira, Gilberto B. Domont

Publikováno v: Circulation Research. 127

Extracellular matrix (ECM) can directly modulate cell proliferation, migration and differentiation by mediating diverse growth factors and signaling interactions. Protocols for cardiomyocyte differentiation of induced pluripotent stem cells (iPSCs) t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e87f5c73aa9c50c172a276670955052d
https://doi.org/10.1161/res.127.suppl_1.281

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Whole Heart Engineering: Advances and Challenges

Autor: Doris A. Taylor, Jacquelynn Morrissey, Camila Hochman-Mendez, Fernanda C.P. Mesquita

Publikováno v: Cells, tissues, organs. 211(4)

Bioengineering a solid organ for organ replacement is a growing endeavor in regenerative medicine. Our approach – recellularization of a decellularized cadaveric organ scaffold with human cells – is currently the most promising approach to buildi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfaff16c89dd89c72d6f21ec2b25c98a
https://pubmed.ncbi.nlm.nih.gov/33640893

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