Core-Shell Polymer-Based Nanoparticles Deliver miR-155-5p to Endothelial Cells

Autor: Joana C. Antunes, Louise Benarroch, Fernanda C. Moraes, Maya Juenet, Marie-Sylvie Gross, Mélodie Aubart, Catherine Boileau, Giuseppina Caligiuri, Antonino Nicoletti, Véronique Ollivier, Frédéric Chaubet, Didier Letourneur, Cédric Chauvierre

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 210-222 (2019)

Heart failure occurs in over 30% of the worldwide population and most commonly originates from cardiovascular diseases such as myocardial infarction. microRNAs (miRNAs) target and silence specific mRNAs, thereby regulating gene expression. Because th

Externí odkaz: https://doaj.org/article/7076cb5fefbb459980c54193d038639e

miRNA Delivery by Nanosystems: State of the Art and Perspectives

Autor: Didier Letourneur, Chantal Pichon, Fernanda C. Moraes, Frédéric Chaubet

Publikováno v: Pharmaceutics, Vol 13, Iss 1901, p 1901 (2021)
Pharmaceutics
Pharmaceutics, MDPI, 2021, 13 (11), pp.1901. ⟨10.3390/pharmaceutics13111901⟩
Pharmaceutics, 2021, 13 (11), pp.1901. ⟨10.3390/pharmaceutics13111901⟩

International audience; MicroRNAs (miRNAs) are short (~21–23 nucleotides), non-coding endogenous RNA molecules that modulate gene expression at the post-transcriptional level via the endogenous RNA interference machinery of the cell. They have emer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f699dcc4d87516d0c10d9d82b9865888
https://www.mdpi.com/1999-4923/13/11/1901

Synthesis of cationic quaternized pullulan derivatives for miRNA delivery

Autor: Paola Aprile, Grégory Franck, Cédric Chauvierre, Didier Letourneur, Laura Marcela Forero Ramirez, Frédéric Chaubet, Fernanda C. Moraes, Joana C. Antunes

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2020, 577, pp.119041. ⟨10.1016/j.ijpharm.2020.119041⟩
International Journal of Pharmaceutics, 2020, 577, pp.119041. ⟨10.1016/j.ijpharm.2020.119041⟩

International audience; Pullulan is a natural polysaccharide of potential interest for biomedical applications due to its non-toxic, non-immunogenic and biodegradable properties. The aim of this work was to synthesize cationic pullulan derivatives ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0cac9565abbb2e1399fd791d5f1f4d
https://hal.archives-ouvertes.fr/hal-03022444

Assignment of the relative and absolute stereochemistry of two novel epoxides using NMR and DFT-GIAO calculations

Autor: Fernanda C. Moraes, V.M. Viana, Elson S. Alvarenga, Antonio J. Demuner

Publikováno v: LOCUS Repositório Institucional da UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV

Considering the potential biological application of isobenzofuranones, especially as agrochemical defensives, two novel epoxides, (1aR,2R,2aR,5S,5aS,6S,6aS)-5-(hydroxymethyl)hexahydro-2,6-methanooxireno[2,3-f]isobenzofuran-3(1aH)-one (9), and (1aS,2S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db52681b9936c36994f5a86a13b54f7
http://www.locus.ufv.br/handle/123456789/21834

Novel platensimycin derivatives with herbicidal activity

Autor: Fernanda C, Moraes, Elson S, Alvarenga, Kariny B, Amorim, Antonio J, Demuner, Milton E, Pereira-Flores

Publikováno v: Pest management science. 72(3)

Faced with the need to develop herbicides with different modes of action on account of weed resistance to existing herbicides, the sesquiterpene lactones can be the starting point in the search for new bioactive compounds. Lumisantonin and five novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98a95e215dadd8795c14b30c73978995
https://pubmed.ncbi.nlm.nih.gov/25914183