Výsledky vyhledávání - "Fernanda C. Costa"

Akademický článek

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.

Autor: Archie A Khan, Harry C Langston, Fernanda C Costa, Francisco Olmo, Martin C Taylor, Conor J McCann, John M Kelly, Michael D Lewis

Publikováno v: PLoS Pathogens, Vol 17, Iss 8, p e1009864 (2021)

Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. The mechanism of pathogenesis is poorly understood and the lack of a robust, predictive animal model has held back research. We screened a series of mouse

Externí odkaz: https://doaj.org/article/ce5e49f6159a4b51957df35aa743d66a

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RF21 | PSAT93 Improvement of Final Height in Congenital Adrenal Hyperplasia Patients Treated With Recombinant Growth Hormone

Autor: Fernanda C Costa, Donaldt L de Sousa, Guiomar Madureira, Patrícia M B R Mathias, Berenice B Mendonca, Mirela C Miranda, Mylena C M Silva, Tânia A S S Bachega

Publikováno v: Journal of the Endocrine Society. 6:A138-A138

Final height (FH) in congenital adrenal hyperplasia (CAH) patients is frequently under -1.5 SDS in relation to the normal population, even in those with good compliance, chronic androgen exposure or supraphysiological glucocorticoid doses could corro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c82c8b1b93dfa3ee0d03146491aed27
https://doi.org/10.1210/jendso/bvac150.281

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PSAT072 Clinical Features of Patients with 21-Hydroxylase Deficiency and Testicular Adrenal Rest Tumors

Autor: Tânia A S S Bachega, Fernanda C Costa, Guiomar Madureira, Berenice B Mendonca, Mirela C Miranda

Publikováno v: Journal of the Endocrine Society. 6:A113-A113

Testicular adrenal rest tumors (TARTs) are one of the most frequent comorbidities in males with 21-hydroxylase deficiency (CAH) and different prevalence rates have been reported. TART still present difficult control and frequently lead to infertility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::132d8a52aca78c276bd81177d6821ade
https://doi.org/10.1210/jendso/bvac150.230

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Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

Autor: Francisco Olmo, Fernanda C. Costa, John M. Kelly, Conor J. McCann, Michael D. Lewis, Harry C Langston, Martin C. Taylor, Archie A Khan

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009864 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459ad9da32ac2c8815af7c01581fb173

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Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity

Autor: Martin C. Taylor, Fernanda C. Costa, John M. Kelly, Michael D. Lewis, Alexander I. Ward, Amanda F. Francisco, Shiromani Jayawardhana, Francisco Olmo

Publikováno v: Current pharmaceutical design. 27(14)

Chagas disease results from infection with the trypanosomatid parasite Trypanosoma cruzi. Progress in developing new drugs has been hampered by the long term and complex nature of the condition and by our limited understanding of parasite biology. Te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500dc7c455cf9d2f8f1f3fd84e05fe9a
https://pubmed.ncbi.nlm.nih.gov/33234096

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Real-world impact of glucocorticoid replacement therapy on bone mineral density: retrospective experience of a large single-center CAH cohort spanning 24 years

Autor: Fernanda C. Costa, Berenice B Mendonca, Regina Matsunaga Martin, Bruno Ferraz-de-Souza, T S Bachega, Mirela C Miranda, L L Iervolino

Publikováno v: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 31(5)

The congenital adrenal hyperplasia population seems to have an intrinsic tendency to a high frequency of low bone mass. However in this single-center and long-term evaluated cohort, the simplified corticoid regimen, with exclusive dexamethasone singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b49f9a864d9e11457e7d35cb829496
https://pubmed.ncbi.nlm.nih.gov/31897546

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SUN-361 Reproductive Outcomes in Females with Virilizing Forms of Congenital Adrenal Hyperplasia

Autor: Marlene Inácio, Fernanda C. Costa, Guiomar Madureira, Tania A. S. S. Bachega, Berenice B. Mendonca, Mirela C Miranda, Camila Kruschewsky Falcao, Larissa G. Gomes

Publikováno v: Journal of the Endocrine Society

Subfertility rate has been observed in women with classical CAH, being inversely correlated with the severity of enzymatic defect. Psychosexual behaviors, genital abnormalities, chronic anovulation and/or excessive androgen exposure could corroborate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee28ef85deba7469540a6321a9f5a15d
http://europepmc.org/articles/PMC6553277

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SUN-359 Preserved Bone Mineral Density In Adults With Classical Forms Of Congenital Adrenal Hyperplasia Submitted To Long-term Low Glucocorticoid Doses

Autor: Fernanda C. Costa, Luiz Iervolino, Bruno Ferraz-de-Souza, Berenice B. Mendonca, Regina Matsunaga Martin, Tania A. S. S. Bachega

Publikováno v: Journal of the Endocrine Society

The impact of long-term and supposedly physiological doses of corticosteroids on bone mineral density (BMD) in congenital adrenal hyperplasia (CAH) remains unknown. There are few studies with discordant results performed with mixed clinical forms and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea3fb0c97b968801a6563611b4590ad
https://doi.org/10.1210/js.2019-sun-359

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Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation

Autor: Francisco Olmo, Gurdip Singh Mann, Martin C. Taylor, John M. Kelly, Fernanda C. Costa

Publikováno v: Molecular and Biochemical Parasitology

Highlights • A straightforward method for optimising Trypanosoma cruzi transfection efficiency. • Facilitated by hydroxyurea-induced cell-cycle synchronization. • Applicable to both episomal and integrative-mediated transformation. • Reduces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca2573e5759d198b2ca76a0d815b798
https://researchonline.lshtm.ac.uk/id/eprint/4648474/1/Optimising-genetic-transformation.pdf

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