Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Fernand Gobeil"'
Autor:
Maxime Gagnon, Martin Savard, Thi Minh Hue Tran, Laurence Vincent, Alexandre Moquin, Philippe Tremblay, Xavier Roucou, Yves Dory, Fernand Gobeil
Publikováno v:
Molecules, Vol 28, Iss 13, p 5206 (2023)
The blood–brain barrier (BBB) is a major obstacle to the development of effective therapeutics for central nervous system (CNS) disorders, including Alzheimer’s disease (AD). This has been particularly true in the case of monoclonal antibody (mAb
Externí odkaz:
https://doaj.org/article/2a33785bac604351a2642fcedd60dcaa
Publikováno v:
BioMedical Engineering OnLine, Vol 18, Iss 1, Pp 1-16 (2019)
Abstract Background Stress deprivation (SD) has frequently been used as a model to study tendinopathy. Most of these studies have investigated either short-term (early tendinopathy) or long-term SD (advanced tendinopathy), while the transient mid-ter
Externí odkaz:
https://doaj.org/article/6817238c7a494417b067e3dad764a7c0
Autor:
Melanie Sanchez, David Hamel, Emmanuel Bajon, François Duhamel, Vikrant K. Bhosle, Tang Zhu, Jose Carlos Rivera, Rabah Dabouz, Mathieu Nadeau-Vallée, Nicholas Sitaras, David-Étienne Tremblay, Samy Omri, Tiffany Habelrih, Raphael Rouget, Xin Hou, Fernand Gobeil, Jean-Sébastien Joyal, Przemyslaw Sapieha, Grant Mitchell, Alfredo Ribeiro-Da-Silva, Mohammad Ali Mohammad Nezhady, Sylvain Chemtob
Publikováno v:
Cells, Vol 11, Iss 14, p 2185 (2022)
The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle metabolite succinate. GPCR signaling depends on the surrounding environment and intracellular localization through location bias. Here, we show by microscopy and by ce
Externí odkaz:
https://doaj.org/article/08718907106b4199a8f209beb94c4878
Autor:
Marielza Andrade Nunes, Mariana Toricelli, Natalia Mendes Schöwe, Helena Nascimento Malerba, Karis Ester Dong-Creste, Daniela Moura Azevedo Tuma Farah, Katia De Angelis, Maria Claudia Irigoyen, Fernand Gobeil, Tânia Araujo Viel, Hudson Sousa Buck
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 288 (2020)
Background: Alzheimer’s disease is mainly characterized by remarkable neurodegeneration in brain areas related to memory formation. This progressive neurodegeneration causes cognitive impairment, changes in behavior, functional disability, and even
Externí odkaz:
https://doaj.org/article/f5dbf82f39b44dd68b31393f01a36b62
Autor:
Dina Sikpa, Lisa Whittingstall, Martin Savard, Réjean Lebel, Jérôme Côté, Stephen McManus, Sylvain Chemtob, David Fortin, Martin Lepage, Fernand Gobeil
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 279 (2020)
The blood–brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB permeabi
Externí odkaz:
https://doaj.org/article/1f234223d2b34d019185c362e5097d44
Autor:
Martin Houde, Adel Schwertani, Hanène Touil, Louisane Desbiens, Otman Sarrhini, Roger Lecomte, Martin Lepage, Hugo Gagnon, Shinji Takai, Gunnar Pejler, Danielle Jacques, Fernand Gobeil, Robert Day, Pedro D’Orléans-Juste
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Chymase, a mast cell serine protease involved in the generation of multiple cardiovascular factors, such as angiotensin II and endothelin-1 (ET-1), is elevated and participates in tissue degeneration after permanent myocardial infarction (PMI). Anest
Externí odkaz:
https://doaj.org/article/7ecc202a5ad84f19a487e143256394bc
Autor:
Jérôme Côté, Veronica Bovenzi, Martin Savard, Céléna Dubuc, Audrey Fortier, Witold Neugebauer, Luc Tremblay, Werner Müller-Esterl, Ana-Maria Tsanaclis, Martin Lepage, David Fortin, Fernand Gobeil
Publikováno v:
PLoS ONE, Vol 7, Iss 6 (2012)
Externí odkaz:
https://doaj.org/article/1d4d16666d604768b67cd185bffce97e
Autor:
Jérôme Côté, Veronica Bovenzi, Martin Savard, Céléna Dubuc, Audrey Fortier, Witold Neugebauer, Luc Tremblay, Werner Müller-Esterl, Ana-Maria Tsanaclis, Martin Lepage, David Fortin, Fernand Gobeil
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37485 (2012)
Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability o
Externí odkaz:
https://doaj.org/article/9ac834708c154cb7b2aa8ed969305a24
Autor:
Michelle Re, Macarena Pampillo, Martin Savard, Céléna Dubuc, Craig A McArdle, Robert P Millar, P Michael Conn, Fernand Gobeil, Moshmi Bhattacharya, Andy V Babwah
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11489 (2010)
The mammalian type I gonadotropin releasing hormone receptor (GnRH-R) is a structurally unique G protein-coupled receptor (GPCR) that lacks cytoplasmic tail sequences and displays inefficient plasma membrane expression (PME). Compared to its murine c
Externí odkaz:
https://doaj.org/article/0d60d3ede10340949374b541eaa8c83f
Autor:
Jean-Luc Ardilouze, Fernand Gobeil, Ran Cheng, Julie Ménard, Danijela Bovan, Virginie Messier, Martin Savard, Jean-Patrice Baillargeon, Rémi Rabasa-Lhoret
Publikováno v:
Canadian Journal of Diabetes. 47:180-184