Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Fernaldo Richtia, Winnerdy"'
Autor:
Sudarsan Mugunthan, Lan Li Wong, Fernaldo Richtia Winnerdy, Stephen Summers, Muhammad Hafiz Bin Ismail, Yong Hwee Foo, Tavleen Kaur Jaggi, Oliver W. Meldrum, Pei Yee Tiew, Sanjay H. Chotirmall, Scott A. Rice, Anh Tuân Phan, Staffan Kjelleberg, Thomas Seviour
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The extracellular matrix of bacterial biofilms consists of diverse components including polysaccharides, proteins and DNA. Extracellular RNA (eRNA) can also be present, contributing to the structural integrity of biofilms. However, technical
Externí odkaz:
https://doaj.org/article/c07281c1d6b64fdb91b7178ccf61bcae
Autor:
Thomas Seviour, Fernaldo Richtia Winnerdy, Lan Li Wong, Xiangyan Shi, Sudarsan Mugunthan, Yong Hwee Foo, Remi Castaing, Sunil S. Adav, Sujatha Subramoni, Gurjeet Singh Kohli, Heather M. Shewan, Jason R. Stokes, Scott A. Rice, Anh Tuân Phan, Staffan Kjelleberg
Publikováno v:
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Extracellular DNA, or eDNA, is recognised as a critical biofilm component; however, it is not understood how it forms networked matrix structures. Here, we isolate eDNA from static-culture Pseudomonas aeruginosa biofilms using ionic liquids
Externí odkaz:
https://doaj.org/article/70e8aa33fa1741feb38ae9235c2d9402
Autor:
Csaba Papp, Vineeth T Mukundan, Piroon Jenjaroenpun, Fernaldo Richtia Winnerdy, Ghim Siong Ow, Anh Tuân Phan, Vladimir A Kuznetsov
Publikováno v:
Nucleic Acids Research. 51:4148-4177
DNA sequence composition determines the topology and stability of G-quadruplexes (G4s). Bulged G-quadruplex structures (G4-Bs) are a subset of G4s characterized by 3D conformations with bulges. Current search algorithms fail to capture stable G4-B, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694db42a825b28bfa6e7c7dae501b692
https://doi.org/10.1093/nar/gkad252
https://doi.org/10.1093/nar/gkad252
Publikováno v:
Biochemistry. 60:1097-1107
Aberrant expansion of the hexanucleotide GGGGCC (or G₄C₂) repeat in the human C9ORF72 gene is the most common genetic factor found behind amyotrophic lateral sclerosis and frontotemporal dementia. The hypothesized pathways, through which the repe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76f57087e8ad0ea773a8f4d671960da4
https://doi.org/10.1021/acs.biochem.0c00916
https://doi.org/10.1021/acs.biochem.0c00916
Publikováno v:
Nucleic Acids Research
The triple-negative breast cancer (TNBC), a subtype of breast cancer which lacks of targeted therapies, exhibits a poor prognosis. It was shown recently that the PIM1 oncogene is highly related to the proliferation of TNBC cells. A quadruplex–duple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f89711aaa22e859c540f9cac7e44a8
https://doi.org/10.1093/nar/gkaa752
https://doi.org/10.1093/nar/gkaa752
Publikováno v:
Nucleic Acids Research
G-rich DNA sequences with tracts of three or more continuous guanines (G≥3) are known to have high propensity to adopt stable G-quadruplex (G4) structures. Bioinformatic analyses suggest high prevalence of G-rich sequences with short G-tracts (G≤
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8829c19d550e5ae7fe1c185fd9df1f
https://doi.org/10.1093/nar/gkaa008
https://doi.org/10.1093/nar/gkaa008
Autor:
Mark C.M. van Loosdrecht, Yang Lu, Thomas Seviour, Marissa Boleij, Lan Li Wong, Jong-Min Lee, Sara Swi Thi, Sudarsan Mugunthan, Fernaldo Richtia Winnerdy, Yuemei Lin, Yingyu Law, Gayathri Natarajan, Staffan Kjelleberg
Publikováno v:
Applied Microbiology and Biotechnology. 104:3643-3654
Anaerobic ammonium oxidation (anammox)-performing bacteria self-assemble into compact biofilms by expressing extracellular polymeric substances (EPS). Anammox EPS are poorly characterized, largely due to their low solubility in typical aqueous solven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa4cad4d027934a662c28d0d02c4854
https://doi.org/10.1007/s00253-020-10465-7
https://doi.org/10.1007/s00253-020-10465-7
Publikováno v:
Biochemical and biophysical research communications. 613
93del is a 16-nucleotide G-quadruplex-forming aptamer which can inhibit the activity of the HIV-1 integrase enzyme at nanomolar concentration. Previous structural analyses of 93del using NMR spectroscopy have shown that the aptamer forms an interlock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3525726022a9807534d8ad374e4517
https://pubmed.ncbi.nlm.nih.gov/35561583
https://pubmed.ncbi.nlm.nih.gov/35561583
A four-stranded scaffold of nucleic acids termed G-quadruplex (G4) has found growing applications in nano- and biotechnology. Propeller loops are a hallmark of the most stable intramolecular parallel-stranded G4s. To date, propeller loops have been o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cbf9560b541090633278776621b665
https://hdl.handle.net/10356/158330
https://hdl.handle.net/10356/158330
Autor:
Yong Hwee Foo, Heather M. Shewan, Anh Tuân Phan, Rémi Castaing, Thomas Seviour, Fernaldo Richtia Winnerdy, Scott A. Rice, Sujatha Subramoni, Lan Li Wong, Sunil S. Adav, Jason R. Stokes, Gurjeet S. Kohli, Sudarsan Mugunthan, Xiangyan Shi, Staffan Kjelleberg
Publikováno v:
Seviour, T, Winnerdy, F R, Wong, L L, Shi, X, Mugunthan, S, Foo, Y H, Castaing, R, Adav, S S, Subramoni, S, Kohli, G S, Shewan, H M, Stokes, J R, Rice, S A, Phan, A T & Kjelleberg, S 2021, ' The biofilm matrix scaffold of Ps eudomonas aeruginosa contains G-quadruplex extracellular DNA structures ', npj Biofilms and Microbiomes, vol. 7, no. 1, 27 . https://doi.org/10.1038/s41522-021-00197-5
NPJ Biofilms and Microbiomes
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-12 (2021)
NPJ Biofilms and Microbiomes
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-12 (2021)
Extracellular DNA, or eDNA, is recognised as a critical biofilm component; however, it is not understood how it forms networked matrix structures. Here, we isolate eDNA from static-culture Pseudomonas aeruginosa biofilms using ionic liquids to preser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21d125ab3fdf74686b36318d31381ee
https://pure.au.dk/portal/da/publications/the-biofilm-matrix-scaffold-of-ps-eudomonas-aeruginosa-contains-gquadruplex-extracellular-dna-structures(32ab01ed-b330-4d95-bce4-2794fe70f530).html
https://pure.au.dk/portal/da/publications/the-biofilm-matrix-scaffold-of-ps-eudomonas-aeruginosa-contains-gquadruplex-extracellular-dna-structures(32ab01ed-b330-4d95-bce4-2794fe70f530).html