Výsledky vyhledávání - "Fernão C. Braga"

Akademický článek

Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

Publikováno v: Pharmacological Research, Vol 177, Iss , Pp 106076- (2022)

Drug discovery from natural sources is going through a renaissance, having spent many decades in the shadow of synthetic molecule drug discovery, despite the fact that natural product-derived compounds occupy a much greater chemical space than those

Externí odkaz: https://doaj.org/article/7548a631600c45a6b94850aa79d2813e

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Akademický článek

Determination of l-(+)-bornesitol, the hypotensive constituent of Hancornia speciosa, in rat plasma by LC-MS/MS and its application on a pharmacokinetic study

Autor: Luciana N. Moreira, Clarissa Feltrin, José E. Gonçalves, Whocely V. de Castro, Cláudia M.O. Simões, Rodrigo M. de Pádua, Steyner F. Cortes, Fernão C. Braga

Publikováno v: Biomedicine & Pharmacotherapy, Vol 132, Iss , Pp 110900- (2020)

Hancornia speciosa is a medicinal plant with proven antihypertensive activity. The cyclitol l-(+)-bornesitol is the main constituent of its leaves and is a potent inhibitor of the angiotensin-converting enzyme. We herein investigated the pharmacokine

Externí odkaz: https://doaj.org/article/5ccb7335a7654b6c85f91647cf59cffa

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Akademický článek

Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death

Autor: Naira F. Z. Schneider, Claudia Cerella, Jin-Young Lee, Aloran Mazumder, Kyung Rok Kim, Annelise de Carvalho, Jennifer Munkert, Rodrigo M. Pádua, Wolfgang Kreis, Kyu-Won Kim, Christo Christov, Mario Dicato, Hyun-Jung Kim, Byung Woo Han, Fernão C. Braga, Cláudia M. O. Simões, Marc Diederich

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Cardiac glycosides (CGs) are natural compounds used traditionally to treat congestive heart diseases. Recent investigations repositioned CGs as potential anticancer agents. To discover novel cytotoxic CG scaffolds, we selected the cardenolide glucoev

Externí odkaz: https://doaj.org/article/1962657514af42deb6f0eab6afdc2661

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Akademický článek

Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice

Autor: Mauro M. Teixeira, Marina G. M. Castor, Fernão C. Braga, Danielle G. Souza, Rosa M. E. Arantes, Carolina B. Resende, Priscila T. T. Bernardes, Barbara M. Rezende, Vanessa Pinho

Publikováno v: Marine Drugs, Vol 11, Iss 7, Pp 2595-2615 (2013)

Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which is a member of a group of algae with anti-inflammatory, antitumor, and immunomodulatory properties. The present study evaluated the effects of treatment with Lithothamnion muelleri ex

Externí odkaz: https://doaj.org/article/b1013c1d4a09411e99547279ae7d0345

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Akademický článek

Isolation and HPLC quantitation of kaurane-type diterpenes and cinnamic acid derivatives of long-term stored leaves of Mikania laevigata and Mikania glomerata

Autor: SUZAN K.V. BERTOLUCCI, ANA B.D. PEREIRA, JOSÉ E.B.P. PINTO, ALAÍDE B. OLIVEIRA, FERNÃO C. BRAGA

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 85, Iss 2, Pp 473-486 (2013)

The leaves of Mikania laevigata and Mikania glomerata are used in Brazil to treat respiratory affections, being kaurane-type diterpenes and coumarin considered as the bioactive compounds. The present study reports an investigation on the HPLC-DAD pro

Externí odkaz: https://doaj.org/article/addbd11e225b4832b78ca7387ae3117f

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Akademický článek

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Autor: Alaíde B. Oliveira, Maria Fâni Dolabela, Fernão C. Braga, Rose L.R.P. Jácome, Fernando P. Varotti, Marinete M. Póvoa

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 81, Iss 4, Pp 715-740 (2009)

Malaria remains one of the most serious world health problem and the major cause of mortality and morbidity in the endemic regions. Brazil is among the 30 high-burden countries and most of the cases occur in the Legal Amazonian Region. New chemothera

Externí odkaz: https://doaj.org/article/d9e0fe555b714c4c95965a9ef70c75fe

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Ouratea spectabilis and its Biflavanone Ouratein D Exert Potent Anti-inflammatory Activity in MSU Crystal-induced Gout in Mice

Autor: Marina P. Rocha, Diego P. Oliveira, Vivian L. S. de Oliveira, Isabella Zaidan, Laís C. Grossi, Priscilla R. V. Campana, Flávio A. Amaral, Lirlândia P. Sousa, Mauro M. Teixeira, Fernão C. Braga

Publikováno v: Planta Medica.

Gouty arthritis (GA) is an inflammatory arthritis triggered by the deposition of monosodium urate monohydrate (MSU) crystals, causing pain, inflammation, and joint damage. Several drugs are currently employed to manage acute flares of GA, but they ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a48b4e8db32ec534c6b93a67da255ff
https://doi.org/10.1055/a-2009-9809

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