Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis

Autor: Böttcher, C., van der Poel, M., Fernández-Zapata, C., Schlickeiser, S., Leman, J.K.H., Hsiao, C.-C., Mizee, M.R., Adelia, Vincenten, M.C.J., Kunkel, D., Huitinga, I., Hamann, J., Priller, J.

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-18 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications 8(1), 136 (2020). doi:10.1186/s40478-020-01010-8
Acta neuropathologica communications, 8(1). BioMed Central
Acta neuropathologica communications, 8(1):136. BioMed Central
Acta Neuropathologica Communications, 8:136. BioMed Central

Myeloid cells contribute to inflammation and demyelination in the early stages of multiple sclerosis (MS), but it is still unclear to what extent these cells are involved in active lesion formation in progressive MS (PMS). Here, we have harnessed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827a2cd3238f9a9c901e6fcd08e3b1f0
http://link.springer.com/article/10.1186/s40478-020-01010-8

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Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

Autor: Böttcher, C., Fernández-Zapata, C., Schlickeiser, S., Kunkel, D., Schulz, A.R., Mei, H.E., Weidinger, C., Gieß, R.M., Asseyer, S., Siegmund, B., Paul, F., Ruprecht, K., Priller, J.

Publikováno v: Scientific reports 9(1), 19471 (2019). doi:10.1038/s41598-019-55852-x
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). Studies in rodent models demonstrated an association of CNS-infiltrating monocyte-derived macrophages with disease severity. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc00df5264e9b62af103180cdcc39ab1

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