Safety, tolerability, and immunogenicity of a SARS-CoV-2 recombinant spike RBD protein vaccine: A randomised, double-blind, placebo-controlled, phase 1-2 clinical trial (ABDALA Study).

Autor: Hernández-Bernal F; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Ricardo-Cobas MC; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Martín-Bauta Y; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Navarro-Rodríguez Z; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Piñera-Martínez M; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Quintana-Guerra J; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Urrutia-Pérez K; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Urrutia-Pérez K; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Chávez-Chong CO; Institute of Cybernetics, Mathematics and Physics, Havana, Cuba., Azor-Hernández JL; Institute of Cybernetics, Mathematics and Physics, Havana, Cuba., Rodríguez-Reinoso JL; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Lobaina-Lambert L; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Colina-Ávila E; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Bizet-Almeida J; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Rodríguez-Nuviola J; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Del Valle-Piñera S; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Ramírez-Domínguez M; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Tablada-Ferreiro E; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Alonso-Valdés M; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Lemos-Pérez G; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Guillén-Nieto GE; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Palenzuela-Díaz A; Immunoassay Centre, Havana, Cuba., Noa-Romero E; Civilian Defense Scientific Research Centre, San José de las Lajas, Mayabeque, Cuba., Limonta-Fernández M; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Fernández-Ávila JM; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Ali-Mros NA; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Del Toro-Lahera L; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Remedios-Reyes R; 'Saturnino Lora' Hospital, P.O. Box 90100, Santiago de Cuba, Cuba., Ayala-Ávila M; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba., Muzio-González VL; Centre for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana, Cuba.

Publikováno v: EClinicalMedicine [EClinicalMedicine] 2022 Apr; Vol. 46, pp. 101383. Date of Electronic Publication: 2022 Apr 09.