NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program

Autor: FitzPatrick, Lorna M., Hawkins, Kate E., Delhove, Juliette M.K.M., Fernández Sánchez, Emilio, Soldati, Chiara, Bullen, Louise F., Nohturfft, Axel, Waddington, Simon N., Medina, Diego L., Bolaños Hernández, Juan Pedro, McKay, Tristan R.

Publikováno v: GREDOS. Repositorio Institucional de la Universidad de Salamanca
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Digital.CSIC. Repositorio Institucional del CSIC
Stem Cell Reports
GREDOS: Repositorio Institucional de la Universidad de Salamanca
Universidad de Salamanca (USAL)

Summary Human neural development begins at embryonic day 19 and marks the beginning of organogenesis. Neural stem cells in the neural tube undergo profound functional, morphological, and metabolic changes during neural specification, coordinated by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::67e6a831512ed199c576b11c65ac58d4
https://openaccess.sgul.ac.uk/id/eprint/109750/1/2018_FitzPatrick_StemCellReports.pdf

Knockdown of glutamate-cysteine ligase by small hairpin RNA (shRNA) reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons

Autor: Díaz Hernández, Juan Ignacio, Almeida Parra, Ángeles, Delgado Esteban, María, Fernández Sánchez, Emilio, Bolaños Hernández, Juan Pedro

Publikováno v: GREDOS. Repositorio Institucional de la Universidad de Salamanca
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El silenciamiento génico mediante RNAi de cada una de las dos subunidades que conforman la glutamato-cisteína ligasa (enzima limitante de la biosíntesis de glutation) es capaz de inducir apoptosis neuronal por disminución de su capacidad antioxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::17044ac264d7fd56d9ddd1c1aa2c3abc
http://hdl.handle.net/10366/17709