Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression

Autor: Latorre J, Ortega F, Oliveras-Cañellas N, Comas F, Lluch A, Gavalda A, Moron S, Ricart W, Villarroya F, Giralt M, Fernández-Real JM, Moreno-Navarrete JM

Publikováno v: MOLECULAR THERAPY-NUCLEIC ACIDS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname

Lipopolysaccharide binding protein (Lbp) has been recently identified as a relevant component of innate immunity response associated to adiposity. Here, we aimed to investigate the impact of adipose tissue Lbp on weight gain and white adipose tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::c7e0a98c7cb50c0f84535722f716b4a6
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20748

FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations

Autor: Moron S, Uriarte I, Berasain C, Avila MA, Sabater-Masdeu M, Moreno-Navarrete JM, Fernández-Real JM, Giralt M, Villarroya F, Gavalda A

Publikováno v: molecular metabolism
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

OBJECTIVE: To determine the role of enterokine FGF15/19 in adipose tissue thermogenic adaptations. METHODS: Circulating FGF19 and gene expression (qRT-PCR) levels were assessed in subcutaneous adipose tissue from obese human patients. Effects of expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::970582b352a37f33467ca771d1d8d95b
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18969

Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile

Autor: Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Burokas A, Pérez-Brocal V, Moya A, Portero-Otin M, Ricart W, Maldonado R, Fernández-Real JM

Publikováno v: Microbiome
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
instname

Background The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of alpha-melanocyte-stimulating hormone (alpha-MSH) implicated in body weight regulation in mice. We here investigated the potential associations of gut bacterial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::421a2108080162ab23f3f9ced0abd295
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=7387

Combining metabolic profiling of plasma and faeces as a fingerprint of insulin resistance in obesity

Autor: Palomino-Schätzlein M, Mayneris-Perxachs J, Caballano-Infantes E, Rodríguez MA, Palomo-Buitrago ME, Xiao X, Mares R, Ricart W, Simó R, Herance JR, Fernández-Real JM

Publikováno v: CLINICAL NUTRITION
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname

Insulin resistance (IR) is one of the main risk factor for type 2 diabetes mellitus (T2DM). Nevertheless, its underlying pathophysiology is not completely established because IR is triggered by a complex interconnection of numerous factors impairing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1595f3e6cab3ae601e574f7df17fc1ba
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3440

Integrated systems biology to study the contribution of the gut microbiome to steatosis in obese women

Autor: Hoyles, L, Fernández-Real, JM, Federici, M, Serino, M, Azalbert, V, Blasco, V, Abbott, J, Barton, RH, Puig, J, Xifra, G, Ricart, W, Woodbridge, M, Tomlinson, C, Cardellini, M, Davato, F, Cardolini, I, Porzio, O, Gentilieschi, P, Lopez, F, Foufelle, F, Postic, C, Butcher, SA, Holmes, E, Nicholson, JK, Burcelin, R, Dumas, ME

Publikováno v: Exploring Human Host-Microbiome Interactions in Health and Disease

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease, increasing in worldwide prevalence as a result of the obesity epidemic. It manifests in hepatic cells as steatosis with or without lobular inflammati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::ce72d63487682d34ad67a66c505df308
http://hdl.handle.net/10044/1/52673