Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry

Autor: Ferhati, Xhenti, Jiménez-Moreno, Ester, Hoyt, Emily A., Salluce, Giulia, Cabeza-Cabrerizo, Mar, Navo, Claudio D., Compañón, Ismael, Akkapeddi, Padma, Matos, Maria J., Salaverri, Noelia, Garrido, Pablo, Martínez, Alfredo, Laserna, Víctor, Murray, Thomas V., Jiménez-Osés, Gonzalo, Ravn, Peter, Bernardes, Gonçalo J. L., Corzana, Francisco, 0000-0002-5045-433X, 0000-0001-6940-8803, 0000-0002-1615-6822, 0000-0003-0161-412X, 0000-0002-3470-8299, 0000-0002-5960-8569, 0000-0003-4882-4044, 0000-0003-0105-4337, 0000-0001-6594-8917, 0000-0001-5597-8127

Publikováno v: RIUR. Repositorio Institucional de la Universidad de La Rioja
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Copyright © 2022 The Authors. Published by American Chemical Society
Antibody-drug conjugates (ADCs) are a class of targeted therapeutics used to selectively kill cancer cells. It is important that they remain intact in the bloodstream and rele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602082ac290726aecf4a1ef02e832266

Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation

Autor: Ferhati, Xhenti, Salas-Cubero, Marina, Garrido, Pablo, García-Sanmartín, Josune, Guerreiro, Ana, Avenoza, Alberto, Busto, Jesús H., Peregrina, Jesús M., Martínez, Alfredo, Jiménez-Moreno, Ester, Bernardes, Gonçalo J.L., Corzana, Francisco, 0000-0002-5960-8569, 0000-0003-4391-5537, 0000-0003-4403-4790, 0000-0003-3778-7065, 0000-0003-4882-4044, 0000-0002-5045-433X, 0000-0001-6594-8917, 0000-0001-5597-8127

Publikováno v: RIUR. Repositorio Institucional de la Universidad de La Rioja
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Organic Letters

A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pKa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf3ce4a65120f0ca5e2e1e332ed0feb
https://investigacion.unirioja.es/documentos/62b1d2e3af66e27e1a067f79

Recent advances on smart glycoconjugate vaccines in infections and cancer.

Autor: Anderluh, Marko, Berti, Francesco, Bzducha‐Wróbel, Anna, Chiodo, Fabrizio, Colombo, Cinzia, Compostella, Federica, Durlik, Katarzyna, Ferhati, Xhenti, Holmdahl, Rikard, Jovanovic, Dragana, Kaca, Wieslaw, Lay, Luigi, Marinovic‐Cincovic, Milena, Marradi, Marco, Ozil, Musa, Polito, Laura, Reina, Josè Juan, Reis, Celso A., Sackstein, Robert, Silipo, Alba

Publikováno v: FEBS Journal; Jul2022, Vol. 289 Issue 14, p4251-4303, 53p

Design of smart linkers and their applications in controlled-release drug delivery systems

Autor: Ferhati, Xhenti

Publikováno v: RIUR. Repositorio Institucional de la Universidad de La Rioja
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RIUR: Repositorio Institucional de la Universidad de La Rioja
Universidad de La Rioja (UR)

Los derivados fármaco- anticuerpo representan una interesante estrategia en la terapia antitumoral dirigida. Dicha estrategia combina la gran afinidad que los anticuerpos presentan por sus correspondientes antígenos con la presencia de fármacos al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1b9bbb148399d1d0bc59d8a591c539cf
https://investigacion.unirioja.es/documentos/5e301f36299952391c206be2

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