Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ferguson Stephen SG"'
Autor:
Lorenzen Angela, Samosh Jonathan, Vandewark Kenneth, Anborgh Pieter H, Seah Claudia, Magalhaes Ana C, Cregan Sean P, Ferguson Stephen SG, Pasternak Stephen H
Publikováno v:
Molecular Brain, Vol 3, Iss 1, p 11 (2010)
Abstract Background A central feature of Alzheimer's disease is the cleavage of the amyloid precursor protein (APP) to form beta-amyloid peptide (Aβ) by the β-secretase and γ-secretase enzymes. Although this has been shown to occur after endocytos
Externí odkaz:
https://doaj.org/article/aec0b9aea70e4f7092a02b4732a07759
Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation
Autor:
Nicodemo Alexander A, Pampillo Macarena, Ferreira Lucimar T, Dale Lianne B, Cregan Tamara, Ribeiro Fabiola M, Ferguson Stephen SG
Publikováno v:
Molecular Brain, Vol 3, Iss 1, p 4 (2010)
Abstract Group I metabotropic glutamate receptors (mGluRs) are coupled via Gαq/11 to the activation of phospholipase Cβ, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. This results in the release of
Externí odkaz:
https://doaj.org/article/d60b2d0ee0714124857a072da49af26a
GPCRs represent the largest family of integral membrane proteins and were first identified as receptor proteins that couple via heterotrimeric G-proteins to regulate a vast variety of effector proteins to modulate cellular function. It is now recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56859d29dac922be51cbacd27305d6b8
https://europepmc.org/articles/PMC3372825/
https://europepmc.org/articles/PMC3372825/
Autor:
Qiao Niu
This book reviews the scientific literature and the authors'own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer's disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distributio