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Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury

Autor: Haefeli, J, Mabray, MC, Whetstone, WD, Dhall, SS, Pan, JZ, Upadhyayula, P, Manley, GT, Bresnahan, JC, Beattie, MS, Ferguson, AR, Talbott, JF

Publikováno v: AJNR. American journal of neuroradiology, vol 38, iss 3

Background and purposeAcute markers of spinal cord injury are essential for both diagnostic and prognostic purposes. The goal of this study was to assess the relationship between early MR imaging biomarkers after acute cervical spinal cord injury and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::9ae69b6e843988374a3cd7cd4c7da30e
https://escholarship.org/uc/item/2gf3s4wt

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COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury

Publikováno v: Journal of Clinical Neuroscience, 35, 109-116. Churchill Livingstone

Mild traumatic brain injury (mTBI) results in variable clinical trajectories and outcomes. The source of variability remains unclear, but may involve genetic variations, such as single nucleotide polymorphisms (SNPs). A SNP in catechol-o-methyltransf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b7fd9280c4f56af11771915962eb01a9
https://europepmc.org/articles/PMC5588892/

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Derivation of Multivariate Syndromic Outcome Metrics for Consistent Testing across Multiple Models of Cervical Spinal Cord Injury in Rats

Autor: Segal, Mark, Ferguson, Adam, Beattie, Michael, Ferguson, AR, Irvine, KA, Gensel, JC, Nielson, JL, Lin, A, Ly, J, Segal, MR, Ratan, RR, Bresnahan, JC, Beattie, MS

Publikováno v: Segal, Mark; Ferguson, Adam; Beattie, Michael; Ferguson, AR; Irvine, KA; Gensel, JC; et al.(2013). Derivation of Multivariate Syndromic Outcome Metrics for Consistent Testing across Multiple Models of Cervical Spinal Cord Injury in Rats. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5dp20244

Spinal cord injury (SCI) and other neurological disorders involve complex biological and functional changes. Well-characterized preclinical models provide a powerful tool for understanding mechanisms of disease; however managing information produced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::db699b8fdab9a42e45dab49178eceb36
http://www.escholarship.org/uc/item/5dp20244

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Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury

Autor: Yuh, EL, Mukherjee, P, Lingsma, Hester, Yue, JK, Ferguson, AR, Gordon, WA, Valadka, AB, Schnyer, DM, Okonkwo, DO, Maas, AIR (Arne), Manley, GT

Publikováno v: Annals of Neurology, 73(2), 224-235. John Wiley & Sons Inc.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::56cecdb9ff204c6e8625448e4beb2345
https://pure.eur.nl/en/publications/9eb5c6c9-6818-4307-9cf9-cae7362d91a3

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Tumor necrosis factor alpha mediates GABA(A) receptor trafficking to the plasma membrane of spinal cord neurons in vivo

Autor: Ferguson, Adam, Stück, ED, Christensen, RN, Huie, JR, Tovar, CA, Miller, BA, Nout, YS, Bresnahan, JC, Beattie, MS, Ferguson, AR

Publikováno v: Ferguson, Adam; Stück, ED; Christensen, RN; Huie, JR; Tovar, CA; Miller, BA; et al.(2012). Tumor necrosis factor alpha mediates GABA(A) receptor trafficking to the plasma membrane of spinal cord neurons in vivo.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5fc6v5w3

The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. TNFα contributes to excitotoxicity by increasing GluA2-lacking AMPA receptor (AMPAR) trafficking to the ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::42359fdd4aff4323bd209df95f40ee04
http://www.escholarship.org/uc/item/5fc6v5w3

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Glial tumor necrosis factor alpha (TNFα) generates metaplastic inhibition of spinal learning

Autor: Ferguson, Adam, Beattie, Michael, Huie, JR, Baumbauer, KM, Lee, KH, Bresnahan, JC, Beattie, MS, Ferguson, AR, Grau, JW

Publikováno v: Ferguson, Adam; Beattie, Michael; Huie, JR; Baumbauer, KM; Lee, KH; Bresnahan, JC; et al.(2012). Glial tumor necrosis factor alpha (TNFα) generates metaplastic inhibition of spinal learning. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1z2620kd

Injury-induced overexpression of tumor necrosis factor alpha (TNFα) in the spinal cord can induce chronic neuroinflammation and excitotoxicity that ultimately undermines functional recovery. Here we investigate how TNFα might also act to upset spin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::26a82aebf94b306949f9f5015798fe92
http://www.escholarship.org/uc/item/1z2620kd

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