Zobrazeno 1 - 10 of 228 pro vyhledávání: '"Fergus J. Cameron"'
1
Akademický článek
A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific
Autor: Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia, Chris Y. Chiu, Xin Liu, Eleonora Tresoldi, Abby Foster, Laura King, Fergus J. Cameron, Stuart I. Mannering
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
Antigen-driven T-cell proliferation is often measured using fluorescent dye dilution assays, such as the CFSE-based proliferation assay. Dye dilution assays have been powerful tools to detect human CD4+ T-cell responses, particularly against autoanti
Externí odkaz: https://doaj.org/article/dcd1140ad2bc4508954d95b6411be44b
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2
Akademický článek
Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data
Autor: Farid H. Mahmud, Antoine B. M. Clarke, Yesmino Elia, Jacqueline Curtis, Paul Benitez-Aguirre, Fergus J. Cameron, Scott T. Chiesa, Cheril Clarson, Jennifer J. Couper, Maria E. Craig, R. Neil Dalton, Denis Daneman, Elizabeth A. Davis, John E. Deanfield, Kim C. Donaghue, Timothy W. Jones, Sally M. Marshall, Andrew Neil, M. Loredana Marcovecchio
Publikováno v: BMC Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Given limited data regarding the involvement of disadvantaged groups in paediatric diabetes clinical trials, this study aimed to evaluate the socioeconomic representativeness of participants recruited into a multinational clinical
Externí odkaz: https://doaj.org/article/27ef85e4176541e7954e50dc16a4c90f
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3
Akademický článek
Glutamine deamidation does not increase the immunogenicity of C-peptide in people with type 1 diabetes
Autor: Abby Foster, Pushpak Bhattacharjee, Eleonora Tresoldi, Miha Pakusch, Fergus J. Cameron, Stuart I. Mannering
Publikováno v: Journal of Translational Autoimmunity, Vol 6, Iss , Pp 100180- (2023)
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease in which the insulin-producing beta cells are destroyed. While it is clear that full-length C-peptide, derived from proinsulin, is a major antigen in human T1D it is not clear how and why
Externí odkaz: https://doaj.org/article/d969b5896d19435a8b498d4e2ad0e1e6
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4
Akademický článek
T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
Autor: Mai T. Tran, Pouya Faridi, Jia Jia Lim, Yi Tian Ting, Goodluck Onwukwe, Pushpak Bhattacharjee, Claerwen M. Jones, Eleonora Tresoldi, Fergus J. Cameron, Nicole L. La Gruta, Anthony W. Purcell, Stuart I. Mannering, Jamie Rossjohn, Hugh H. Reid
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Epitopes formed by fusion of more than one self peptide, such as proinsulin and other β cell proteins, can result in the formation of non-self hybrid peptides that can potentially trigger autoimmune responses. Here the authors show how TRBV5 + T cel
Externí odkaz: https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab57
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7
Akademický článek
Higher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices.
Autor: Anne-Louise Ponsonby, Angela Pezic, Fergus J Cameron, Christine Rodda, Andrew S Kemp, John B Carlin, Heikki Hyoty, Amirbabak Sioofy-Khojine, Terence Dwyer, Justine A Ellis, Maria E Craig
Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0193992 (2018)
We aimed to examine the association between parental occupational social contact and hygiene factors on type 1 diabetes (T1D) risk and possible mediation of these effects through child enteroviral infection. We interviewed 333 incident T1D cases and
Externí odkaz: https://doaj.org/article/5f4f1a1637c14378a277def6490cb265
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8
Adolescent ambivalence about diabetes technology-The Janus faces of automated care
Autor: Fergus J. Cameron, Michael Arnold, John W. Gregory
Publikováno v: Pediatric diabetesREFERENCES. 23(8)
The Janus face metaphor approach highlights that a technology may simultaneously have two opposite faces or properties with unforeseen paradoxes within human-technology interaction. Suboptimal acceptance and clinical outcomes are sometimes seen in ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca972ed8d9ed02dd888f32caf211da5a
https://pubmed.ncbi.nlm.nih.gov/36183170
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10
T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
Autor: Goodluck Onwukwe, Mai T. Tran, Jamie Rossjohn, Jia Jia Lim, Eleonora Tresoldi, Nicole L. La Gruta, Claerwen M. Jones, Pouya Faridi, Pushpak Bhattacharjee, Anthony W. Purcell, Fergus J. Cameron, Hugh H. Reid, Yi Tian Ting, Stuart I. Mannering
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides (HIPs) to autoreactive CD4+ T cells. The abundance of spliced peptides binding to HLA-DQ8 and how they are subsequently recognised by the autoreactive T cell re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60d011244d03b6c452fee4a14906f90
https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab57
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