Výsledky vyhledávání - "Fergus E. Poynton"

Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics

Autor: Páraic M. Keane, Clara Zehe, Fergus E. Poynton, Sandra A. Bright, Sandra Estayalo-Adrián, Stephen J. Devereux, Paul M. Donaldson, Igor V. Sazanovich, Michael Towrie, Stanley W. Botchway, Christine J. Cardin, D. Clive Williams, Thorfinnur Gunnlaugsson, Conor Long, John M. Kelly, Susan J. Quinn

Publikováno v: Physical Chemistry Chemical Physics. 24:27524-27531

Time-resolved IR spectra of porphyrins bound to biomolecules are reported. DFT calculations aid porphyrin vibration assignment while distinctive IR bands reveal interactions with therapeutic targets such as quadruplex DNA and proteins in HeLa cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a0ee54e310a305a49a908f369ebd7f
https://doi.org/10.1039/d2cp04604k

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Caught in the Loop: Binding of the [Ru(phen) 2 (dppz)] 2+ Light‐Switch Compound to Quadruplex DNA in Solution Informed by Time‐Resolved Infrared Spectroscopy

Autor: Frederico R. Baptista, Igor V. Sazanovich, Thorfinnur Gunnlaugsson, Fergus E. Poynton, Christine J. Cardin, John M. Kelly, Stephen J. Devereux, Michael Towrie, Susan J. Quinn

Publikováno v: Chemistry – A European Journal. 26:17103-17109

Ultrafast time-resolved infrared (TRIR) is used to report on the binding site of the [Ru(phen)2 (dppz)]2+ "light-switch" complex with both bimolecular (Oxytricha nova telomere) and intramolecular (human telomere) guanine-quadruplex structures in both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15f567a57e43f46c9dc847510794fe19
https://doi.org/10.1002/chem.202002165

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Inosine Can Increase DNA′s Susceptibility to Photo‐oxidation by a RuIIComplex due to Structural Change in the Minor Groove

Autor: Christine J. Cardin, Ian P. Clark, Sarah P. Gurung, Bjørn la Cour Poulsen, Fergus E. Poynton, Michael Towrie, James P. Hall, Susan J. Quinn, Páraic M. Keane, Igor V. Sazanovich, Thorfinnur Gunnlaugsson, John M. Kelly

Publikováno v: Chemistry – A European Journal. 23:10344-10351

Weinheim Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference for a target sequence. For the photo-oxidising lambda-[Ru(TAP)2(dppz)]2+ (Λ-1) (dpp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600a7870e18f9d01de963b80d6bb1243
https://doi.org/10.1002/chem.201701447

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The development of ruthenium(ii) polypyridyl complexes and conjugates forin vitrocellular andin vivoapplications

Autor: Sandra A. Bright, Salvador Blasco, Thorfinnur Gunnlaugsson, D. Clive Williams, John M. Kelly, Fergus E. Poynton

Publikováno v: Chemical Society Reviews. 46:7706-7756

Ruthenium(II) [Ru(II)] polypyridyl complexes have been the focus of intense investigations since work began exploring their supramolecular interactions with DNA. In recent years, there have been considerable efforts to translate this solution-based r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e2973f331eb6c394a17a2c8280c90f
https://doi.org/10.1039/c7cs00680b

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Nanotechnology based therapeutics for lung disease

Autor: Adriele Prina-Mello, Mohammad Doroudian, Ronan MacLoughlin, Seamas C. Donnelly, Fergus E. Poynton

Publikováno v: Thorax. 74(10)

Nanomedicine is a multidisciplinary research field with an integration of traditional sciences such as chemistry, physics, biology and materials science. The application of nanomedicine for lung diseases as a relatively new area of interdisciplinary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1363cecdd760c40351b580459b65be05
https://pubmed.ncbi.nlm.nih.gov/31285360

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Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy

Autor: Christine J. Cardin, Fergus E. Poynton, Igor V. Sazanovich, Susan J. Quinn, David J. Cardin, Páraic M. Keane, Sarah P. Gurung, James P. Hall, John M. Kelly, Michael Towrie, John A. Brazier, Thorfinnur Gunnlaugsson, Graeme Winter

Publikováno v: Nature Chemistry. 7:961-967

To understand the molecular origins of diseases caused by ultraviolet and visible light, and also to develop photodynamic therapy, it is important to resolve the mechanism of photoinduced DNA damage. Damage to DNA bound to a photosensitizer molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c87f6f09bc5d449db9a922cab3612a
https://doi.org/10.1038/nchem.2369

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Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a Ru

Autor: Páraic M, Keane, James P, Hall, Fergus E, Poynton, Bjørn C, Poulsen, Sarah P, Gurung, Ian P, Clark, Igor V, Sazanovich, Michael, Towrie, Thorfinnur, Gunnlaugsson, Susan J, Quinn, Christine J, Cardin, John M, Kelly

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 23(43)

Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference for a target sequence. For the photo-oxidising lambda-[Ru(TAP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59461373e9a968042819bee7cc3880a3
https://pubmed.ncbi.nlm.nih.gov/28543779

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