Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Fergal P. Casey"'
Autor:
Ryan N Gutenkunst, Joshua J Waterfall, Fergal P Casey, Kevin S Brown, Christopher R Myers, James P Sethna
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 10, Pp 1871-1878 (2007)
Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development. Directly measuring in vivo b
Externí odkaz:
https://doaj.org/article/7946c35be1c14192b260ae11c1c21d0f
Autor:
Federica Lombardi, Kalyan Golla, Darren J Fitzpatrick, Fergal P Casey, Niamh Moran, Denis C Shields
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004119 (2015)
Identifying effective therapeutic drug combinations that modulate complex signaling pathways in platelets is central to the advancement of effective anti-thrombotic therapies. However, there is no systems model of the platelet that predicts responses
Externí odkaz:
https://doaj.org/article/2addf7955fee48af83378f5240f6b09c
Autor:
Fergal P. Casey
Publikováno v:
Irish Studies Review. 22:80-90
G.K. Chesterton's 1936 Autobiography affectionately re-creates his first meetings with W.B. Yeats, whose critical thought Chesterton parsed in his 1905 book Heretics. Chesterton was dubious about Yeats's occultism, but attracted by the Irish Revival'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::661334c2ae4da2dc9a6ddc46d1c0144a
https://doi.org/10.1080/09670882.2013.871850
https://doi.org/10.1080/09670882.2013.871850
Autor:
Emilia Huerta-Sanchez, Fergal P. Casey
Publikováno v:
Cell. 175:306-307
In this issue, Enard and Petrov present intriguing results on the possibility of genetic traces left behind in our genomes from adaptation to past viral epidemics that may have been initiated by interaction with Neanderthal archaic hominins. The work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90afaa3dfc72dc31149b691085b031e3
https://doi.org/10.1016/j.cell.2018.09.019
https://doi.org/10.1016/j.cell.2018.09.019
We review a fundamental mathematical model of population genetics that describes the changing frequencies of unlinked genetic variants in a population due to random sampling effects (drift) and the effects of natural selection. We summarize the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82dec9b29f582137a7a98ae2bd724e68
https://doi.org/10.1016/b978-0-12-800049-6.00028-7
https://doi.org/10.1016/b978-0-12-800049-6.00028-7
Publikováno v:
Food Chemistry. 133:1349-1354
The ability of docking to predict angiotensin converting enzyme (ACE) inhibitory dipeptide sequences was assessed using AutoDock Vina. All potential dipeptides and phospho-dipeptides were docked and scored. Peptide intestinal stability was assessed u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b7d3bc2d7ebeea60862a31fcaf1b60
https://doi.org/10.1016/j.foodchem.2012.02.023
https://doi.org/10.1016/j.foodchem.2012.02.023
Publikováno v:
Journal of Chemical Information and Modeling. 48:1524-1529
Protein-protein interactions are fundamental in mediating biological processes including metabolism, cell growth, and signaling. To be able to selectively inhibit or induce protein activity or complex formation is a key feature in controlling disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea96083d7c412bac182a29a61ce71573
https://doi.org/10.1021/ci8000474
https://doi.org/10.1021/ci8000474
Autor:
Emilia Huerta-Sanchez, Fergal P. Casey
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 119(10)
The Tibetan Plateau, often called the roof of the world, sits at an average altitude exceeding 4,500 m. Because of its extreme altitude, the Plateau is one of the harshest human-inhabited environments in the world. This, however, did not impede human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826c6c7144d149668b9485ac386c957e
https://pubmed.ncbi.nlm.nih.gov/26294746
https://pubmed.ncbi.nlm.nih.gov/26294746
Autor:
Kalyan Golla, Federica Lombardi, Darren J. Fitzpatrick, Niamh Moran, Fergal P. Casey, Denis C. Shields
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 11, Iss 4, p e1004119 (2015)
PLoS Computational Biology, Vol 11, Iss 4, p e1004119 (2015)
Identifying effective therapeutic drug combinations that modulate complex signaling pathways in platelets is central to the advancement of effective anti-thrombotic therapies. However, there is no systems model of the platelet that predicts responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5080d44eae5bfb957e10cb488809228
https://pubmed.ncbi.nlm.nih.gov/25875950
https://pubmed.ncbi.nlm.nih.gov/25875950
Publikováno v:
BMC Bioinformatics
BackgroundMechanistic biosimulation can be used in drug development to form testable hypotheses, develop predictions of efficacy before clinical trial results are available, and elucidate clinical response to therapy. However, there is a lack of tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34d0f42693564dc87aebf0bde3806f2
https://doi.org/10.1186/1471-2105-14-221
https://doi.org/10.1186/1471-2105-14-221