Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Fereydoun Hormozdiari"'
Autor:
Mehran Karimzadeh, Amir Momen-Roknabadi, Taylor B. Cavazos, Yuqi Fang, Nae-Chyun Chen, Michael Multhaup, Jennifer Yen, Jeremy Ku, Jieyang Wang, Xuan Zhao, Philip Murzynowski, Kathleen Wang, Rose Hanna, Alice Huang, Diana Corti, Dang Nguyen, Ti Lam, Seda Kilinc, Patrick Arensdorf, Kimberly H. Chau, Anna Hartwig, Lisa Fish, Helen Li, Babak Behsaz, Olivier Elemento, James Zou, Fereydoun Hormozdiari, Babak Alipanahi, Hani Goodarzi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Liquid biopsies have the potential to revolutionize cancer care through non-invasive early detection of tumors. Developing a robust liquid biopsy test requires collecting high-dimensional data from a large number of blood samples across hete
Externí odkaz:
https://doaj.org/article/bfa41ff610b944e99ea17c73581fe401
Autor:
Julie Chow, Matthew Jensen, Hajar Amini, Farhad Hormozdiari, Osnat Penn, Sagiv Shifman, Santhosh Girirajan, Fereydoun Hormozdiari
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, a
Externí odkaz:
https://doaj.org/article/02b18537ec4e431c8533a1420976ad36
Autor:
Farhad Hormozdiari, Bryce van de Geijn, Joseph Nasser, Omer Weissbrod, Steven Gazal, Chelsea J. -T. Ju, Luke O’ Connor, Margaux L. A. Hujoel, Jesse Engreitz, Fereydoun Hormozdiari, Alkes L. Price
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Transposable elements (TE) make up a large component of the human genome and have been shown to contribute to human diseases. Here, Hormozdiari et al. estimate the contribution of TEs to the heritability of 41 complex traits and diseases and find enr
Externí odkaz:
https://doaj.org/article/2162e007b86c49c889aa730a2d6a4779
Publikováno v:
iScience, Vol 18, Iss , Pp 28-36 (2019)
Summary: De novo genetic variants are an important source of causative variation in complex genetic disorders. Many methods for variant discovery rely on mapping reads to a reference genome, detecting numerous inherited variants irrelevant to the phe
Externí odkaz:
https://doaj.org/article/92be6aaf9a58490584377b34c194349e
Autor:
Mark J. P. Chaisson, Ashley D. Sanders, Xuefang Zhao, Ankit Malhotra, David Porubsky, Tobias Rausch, Eugene J. Gardner, Oscar L. Rodriguez, Li Guo, Ryan L. Collins, Xian Fan, Jia Wen, Robert E. Handsaker, Susan Fairley, Zev N. Kronenberg, Xiangmeng Kong, Fereydoun Hormozdiari, Dillon Lee, Aaron M. Wenger, Alex R. Hastie, Danny Antaki, Thomas Anantharaman, Peter A. Audano, Harrison Brand, Stuart Cantsilieris, Han Cao, Eliza Cerveira, Chong Chen, Xintong Chen, Chen-Shan Chin, Zechen Chong, Nelson T. Chuang, Christine C. Lambert, Deanna M. Church, Laura Clarke, Andrew Farrell, Joey Flores, Timur Galeev, David U. Gorkin, Madhusudan Gujral, Victor Guryev, William Haynes Heaton, Jonas Korlach, Sushant Kumar, Jee Young Kwon, Ernest T. Lam, Jong Eun Lee, Joyce Lee, Wan-Ping Lee, Sau Peng Lee, Shantao Li, Patrick Marks, Karine Viaud-Martinez, Sascha Meiers, Katherine M. Munson, Fabio C. P. Navarro, Bradley J. Nelson, Conor Nodzak, Amina Noor, Sofia Kyriazopoulou-Panagiotopoulou, Andy W. C. Pang, Yunjiang Qiu, Gabriel Rosanio, Mallory Ryan, Adrian Stütz, Diana C. J. Spierings, Alistair Ward, AnneMarie E. Welch, Ming Xiao, Wei Xu, Chengsheng Zhang, Qihui Zhu, Xiangqun Zheng-Bradley, Ernesto Lowy, Sergei Yakneen, Steven McCarroll, Goo Jun, Li Ding, Chong Lek Koh, Bing Ren, Paul Flicek, Ken Chen, Mark B. Gerstein, Pui-Yan Kwok, Peter M. Lansdorp, Gabor T. Marth, Jonathan Sebat, Xinghua Shi, Ali Bashir, Kai Ye, Scott E. Devine, Michael E. Talkowski, Ryan E. Mills, Tobias Marschall, Jan O. Korbel, Evan E. Eichler, Charles Lee
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Structural variants (SVs) in human genomes contribute diversity and diseases. Here, the authors use a multi-platform strategy to generate haplotype-resolved SVs for three human parent–child trios.
Externí odkaz:
https://doaj.org/article/1bf8e1b79b09479e9b177f1082c620e1
Autor:
Linh Huynh, Fereydoun Hormozdiari
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Deletions that fuse two adjacent topologically associating domains (TADs) can cause severe developmental disorders. We provide a formal method to quantify deletions based on their potential disruption of the three-dimensional genome structur
Externí odkaz:
https://doaj.org/article/bbbb315f12c244b78496bcfb952530d9
Autor:
Bradley J. Main, Amanda Everitt, Anthony J. Cornel, Fereydoun Hormozdiari, Gregory C. Lanzaro
Publikováno v:
Parasites & Vectors, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Background Malaria mortality rates in sub-Saharan Africa have declined significantly in recent years as a result of increased insecticide-treated bed net (ITN) usage. A major challenge to further progress is the emergence and spread of insec
Externí odkaz:
https://doaj.org/article/be280c2dc7b845a2a9ab98c8a382a230
Autor:
Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis J. Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Ivo Renkens, Bradley P. Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, The Genome of the Netherlands Consortium, André G. Uitterlinden, Cornelia M. van Duijn, Evan E. Eichler, Paul I. W. de Bakker, Morris A. Swertz, Cisca Wijmenga, Gert-Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Alexander Schönhuth, Kai Ye, Victor Guryev
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Structural variants (SVs) are prevalent in genomes of the general population. Here, Guryev and The Genome of the Netherlands Consortium describe the reference panel of haplotype-resolved SVs from 769 individuals from 250 Dutch families and show its u
Externí odkaz:
https://doaj.org/article/cc53ee49aa484f2a8f1598343fa7c306
Autor:
Catarina D Campbell, Kiana Mohajeri, Maika Malig, Fereydoun Hormozdiari, Benjamin Nelson, Gaixin Du, Kristen M Patterson, Celeste Eng, Dara G Torgerson, Donglei Hu, Catherine Herman, Jessica X Chong, Arthur Ko, Brian J O'Roak, Niklas Krumm, Laura Vives, Choli Lee, Lindsey A Roth, William Rodriguez-Cintron, Jose Rodriguez-Santana, Emerita Brigino-Buenaventura, Adam Davis, Kelley Meade, Michael A LeNoir, Shannon Thyne, Daniel J Jackson, James E Gern, Robert F Lemanske, Jay Shendure, Mark Abney, Esteban G Burchard, Carole Ober, Evan E Eichler
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104396 (2014)
Asthma is a complex genetic disease caused by a combination of genetic and environmental risk factors. We sought to test classes of genetic variants largely missed by genome-wide association studies (GWAS), including copy number variants (CNVs) and l
Externí odkaz:
https://doaj.org/article/98e7e72d10cd4b5ca2e3cbed7c9bd96a
Autor:
Andrew McPherson, Fereydoun Hormozdiari, Abdalnasser Zayed, Ryan Giuliany, Gavin Ha, Mark G F Sun, Malachi Griffith, Alireza Heravi Moussavi, Janine Senz, Nataliya Melnyk, Marina Pacheco, Marco A Marra, Martin Hirst, Torsten O Nielsen, S Cenk Sahinalp, David Huntsman, Sohrab P Shah
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 5, p e1001138 (2011)
Gene fusions created by somatic genomic rearrangements are known to play an important role in the onset and development of some cancers, such as lymphomas and sarcomas. RNA-Seq (whole transcriptome shotgun sequencing) is proving to be a useful tool f
Externí odkaz:
https://doaj.org/article/c9b389b739544cc28b879c2f050782a1