Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Ferenc A, Scheeren"'
Autor:
Roderick C. Slieker, Daniël O. Warmerdam, Maarten H. Vermeer, Remco van Doorn, Mirjam H. M. Heemskerk, Ferenc A. Scheeren
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. Allele specific technologies, including recombinant MHC-I technologies, have been extensively used in T cel
Externí odkaz:
https://doaj.org/article/db6bb0c4084a42c19c01bc85581e798a
CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
Autor:
Tom A.W. Schoufour, Anneloes van der Plas - van Duijn, Ian Derksen, Marije Melgers, Jacqueline M.F. van Veenendaal, Claire Lensen, Mirjam H.M. Heemskerk, Jacques Neefjes, Ruud H.M. Wijdeven, Ferenc A. Scheeren
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110120- (2024)
Summary: Human leukocyte antigen (HLA) class-I molecules present fragments of the cellular proteome to the T cell receptor (TCR) of cytotoxic T cells to control infectious diseases and cancer. The large number of combinations of HLA class-I allotypes
Externí odkaz:
https://doaj.org/article/4f8712afc8ef4d058388bf0791f5c4b4
Autor:
Linda J. vanWeele, Sabra I. Djomehri, Shang Cai, Jane Antony, Shaheen S. Sikandar, Dalong Qian, William H. D. Ho, Robert B. West, Ferenc A. Scheeren, Michael F. Clarke
Publikováno v:
Molecular Oncology, Vol 16, Iss 17, Pp 3128-3145 (2022)
As precision medicine increases the response rate of treatment, tumors frequently bypass inhibition, and reoccur. In order for treatment to be effective long term, the mechanisms enabling treatment adaptation need to be understood. Here, we report a
Externí odkaz:
https://doaj.org/article/8d6bdff9fa234733908de5b2990ded0f
Autor:
Iris M. Hagemans, Peter J. Wierstra, Kas Steuten, Janneke D. M. Molkenboer-Kuenen, Duco van Dalen, Martin ter Beest, Johan M. S. van der Schoot, Olga Ilina, Martin Gotthardt, Carl G. Figdor, Ferenc A. Scheeren, Sandra Heskamp, Martijn Verdoes
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background While immune checkpoint inhibitors such as anti-PD-L1 antibodies have revolutionized cancer treatment, only subgroups of patients show durable responses. Insight in the relation between clinical response, PD-L1 expression and intr
Externí odkaz:
https://doaj.org/article/bce30ec5271e44dfb6d7dc4a81599ac1
Autor:
Iris M. Hagemans, Peter J. Wierstra, Kas Steuten, Janneke D. M. Molkenboer-Kuenen, Duco van Dalen, Martin ter Beest, Johan M. S. van der Schoot, Olga Ilina, Martin Gotthardt, Carl G. Figdor, Ferenc A. Scheeren, Sandra Heskamp, Martijn Verdoes
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/145df4837af84e51a6fd6145a71f73f9
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Myeloid immune cells are frequently present in the tumor environment, and although they can positively contribute to tumor control they often negatively impact anticancer immune responses. One way of inhibiting the positive contributions of myeloid c
Externí odkaz:
https://doaj.org/article/9e5b433f0e75451db7985f05e309a250
Autor:
Koen A. Marijt, Marjolein Sluijter, Laura Blijleven, Sofie H. Tolmeijer, Ferenc A. Scheeren, Sjoerd H. van der Burg, Thorbald van Hall
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background T-cell mediated immunotherapy brought clinical success for many cancer patients. Nonetheless, downregulation of MHC class I antigen presentation, frequently occurring in solid cancers, limits the efficacy of these therapies. Unrav
Externí odkaz:
https://doaj.org/article/85c217c823ff441f83eae360b029fc7a
Autor:
Marit J. van Elsas, Johan M. S. van der Schoot, Alexander Bartels, Kas Steuten, Duco van Dalen, Zacharias Wijfjes, Carl G. Figdor, Thorbald van Hall, Sjoerd H. van der Burg, Martijn Verdoes, Ferenc A. Scheeren
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8707 (2022)
Regulatory T cells (Tregs) are major drivers behind immunosuppressive mechanisms and present a major hurdle for cancer therapy. Tregs are characterized by a high expression of CD25, which is a potentially valuable target for Treg depletion to allevia
Externí odkaz:
https://doaj.org/article/9b99950f014f4b1bb3ab28ac5b6c67cb
Autor:
Paula Ruibal, Kees L. M. C. Franken, Krista E. van Meijgaarden, Marjolein van Wolfswinkel, Ian Derksen, Ferenc A. Scheeren, George M. C. Janssen, Peter A. van Veelen, Charlotte Sarfas, Andrew D. White, Sally A. Sharpe, Fabrizio Palmieri, Linda Petrone, Delia Goletti, Thomas Abeel, Tom H. M. Ottenhoff, Simone A. Joosten
Publikováno v:
Journal of Immunology, 209(8)
The Journal of Immunology, 209(8), 1555-1565. AMER ASSOC IMMUNOLOGISTS
The Journal of Immunology, 209(8), 1555-1565. AMER ASSOC IMMUNOLOGISTS
Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, posing great social and economic burden to affected countries. Novel vaccine approaches are needed to increase protective immunity against the causative agent Mycobacterium
Autor:
Shaheen S. Sikandar, Angera H. Kuo, Tomer Kalisky, Shang Cai, Maider Zabala, Robert W. Hsieh, Neethan A. Lobo, Ferenc A. Scheeren, Sopheak Sim, Dalong Qian, Frederick M. Dirbas, George Somlo, Stephen R. Quake, Michael F. Clarke
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tu
Externí odkaz:
https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c