Zobrazeno 1 - 10
of 416
pro vyhledávání: '"Ferenbach A"'
Autor:
Ignacy Czajewski, Bijayalaxmi Swain, Jiawei Xu, Laurin McDowall, Andrew T Ferenbach, Daan MF van Aalten
Publikováno v:
eLife, Vol 13 (2024)
O-GlcNAcylation is an essential intracellular protein modification mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Recently, missense mutations in OGT have been linked to intellectual disability, indicating that this modification is imp
Externí odkaz:
https://doaj.org/article/3fab1c97f5ee4c279e3aa895209f4d0d
Publikováno v:
In Molecular Genetics and Metabolism June 2024 142(2)
Autor:
Florence Authier, Nina Ondruskova, Andrew T. Ferenbach, Alison D. McNeilly, Daan M. F. van Aalten
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/efc22cabbb364e4299dad3bb5b55dac5
Autor:
Leandro R. Soria, Georgios Makris, Alfonso M. D’Alessio, Angela De Angelis, Iolanda Boffa, Veronica M. Pravata, Véronique Rüfenacht, Sergio Attanasio, Edoardo Nusco, Paola Arena, Andrew T. Ferenbach, Debora Paris, Paola Cuomo, Andrea Motta, Matthew Nitzahn, Gerald S. Lipshutz, Ainhoa Martínez-Pizarro, Eva Richard, Lourdes R. Desviat, Johannes Häberle, Daan M. F. van Aalten, Nicola Brunetti-Pierri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Hyperammonemia occurs in liver diseases affecting ureagenesis, and is life-threatening. Here, the authors show that liver UDP-GlcNAc is increased during hyperammonemia, leading to O-GlcNAcylation of the rate-limiting ureagenesis enzyme CPS1, that enh
Externí odkaz:
https://doaj.org/article/f7dd4ac66ee843bca09996d7cef4b0de
Autor:
Bartual, Sergio G., Wei, Wenfan, Zhou, Yao, Pravata, Veronica M., Fang, Wenxia, Yan, Kaizhou, Ferenbach, Andrew T., Lockhart, Deborah E. A., van Aalten, Daan M. F.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2021 Sep . 118(39), 1-10.
Externí odkaz:
https://www.jstor.org/stable/27075863
Autor:
Michaela Omelková, Christina Dühring Fenger, Marta Murray, Trine Bjørg Hammer, Veronica M. Pravata, Sergio Galan Bartual, Ignacy Czajewski, Allan Bayat, Andrew T. Ferenbach, Marios P. Stavridis, Daan M. F. van Aalten
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/6c57373f8d2a40f7b2a046c323d0064e
Autor:
Yan, Kaizhou, Stanley, Mathew, Kowalski, Bartosz, Raimi, Olawale G., Ferenbach, Andrew T., Wei, Pingzhen, Fang, Wenxia, van Aalten, Daan M.F.
Publikováno v:
In Journal of Biological Chemistry June 2022 298(6)
Autor:
Czajewski, Ignacy, Swain, Bijayalaxmi, Jiawei Xu, McDowall, Laurin, Ferenbach, Andrew T., van Aalten, Daan M. F.
Publikováno v:
eLife; 12/6/2024, p1-27, 27p
Autor:
Eoin D. O’Sullivan, Katie J. Mylonas, Rachel Bell, Cyril Carvalho, David P. Baird, Carolynn Cairns, Kevin M. Gallagher, Ross Campbell, Marie Docherty, Alexander Laird, Neil C. Henderson, Tamir Chandra, Kristina Kirschner, Bryan Conway, Gry H. Dihazi, Michael Zeisberg, Jeremy Hughes, Laura Denby, Hassan Dihazi, David A. Ferenbach
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with aging and after injury and are implicated in organ fibrosis, but the mechanisms by which sene
Externí odkaz:
https://doaj.org/article/4b3de86c4fb74e508d5ddb5a3c0e0003
Autor:
Isaac W. Shaw, Eoin D. O'Sullivan, Angela O. Pisco, Gary Borthwick, Kevin M. Gallagher, Bruno Péault, Jeremy Hughes, David A. Ferenbach
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 8, Pp 1232-1248 (2021)
Abstract The renal mesenchyme contains heterogeneous cells, including interstitial fibroblasts and pericytes, with key roles in wound healing. Although healing is impaired in aged kidneys, the effect of age and injury on the mesenchyme remains poorly
Externí odkaz:
https://doaj.org/article/42a9b397f5f6498cbf0976b58102e425