Výsledky vyhledávání - "Ferdy R. van Diemen"

Akademický článek

Viral gene delivery vectors: the next generation medicines for immune-related diseases

Autor: Peter De Haan, Ferdy R. Van Diemen, Miguel G. Toscano

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 17, Iss 1, Pp 14-21 (2021)

Viruses have evolved to efficiently express their genes in host cells, which makes them ideally suited as gene delivery vectors for gene and immunotherapies. Replication competent (RC) viral vectors encoding foreign or self-proteins induce strong T-c

Externí odkaz: https://doaj.org/article/7c77607ffd914eba917339b41397b390

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Viral gene delivery vectors: the next generation medicines for immune-related diseases

Autor: Ferdy R. van Diemen, Peter de Haan, Miguel G. Toscano

Publikováno v: Human Vaccines & Immunotherapeutics
article-version (VoR) Version of Record

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5120e9196b5c50baa78eeb9751c324ee
https://doi.org/10.1080/21645515.2020.1757989

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Akademický článek

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Autor: Peter Tsvetkov, Marc L Mendillo, Jinghui Zhao, Jan E Carette, Parker H Merrill, Domagoj Cikes, Malini Varadarajan, Ferdy R van Diemen, Josef M Penninger, Alfred L Goldberg, Thijn R Brummelkamp, Sandro Santagata, Susan Lindquist

Publikováno v: eLife, Vol 4 (2015)

Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vulnerable to environmental insults, cellular protein imbalance and targeted pharmaceuticals. Yet, mechanisms that cells deploy to counteract inhibition o

Externí odkaz: https://doaj.org/article/ccbe588bb5ce4c2badc9e24644ddeeef

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BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised

Autor: Vincent A. Blomen, Louise M.E. Janssen, Jonne A. Raaijmakers, Roy G.H.P. van Heesbeen, Thijn R. Brummelkamp, Ferdy R. van Diemen, René H. Medema

Publikováno v: Cell Reports, Vol 22, Iss 6, Pp 1424-1438 (2018)

Summary: The spindle assembly checkpoint (SAC) ensures faithful segregation of chromosomes. Although most mammalian cell types depend on the SAC for viability, we found that human HAP1 cells can grow SAC independently. We generated MAD1- and MAD2-def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7677c70d406445f39a58c508f3bad79d
http://www.sciencedirect.com/science/article/pii/S2211124718300664

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A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

Autor: Toin H. van Kuppevelt, Emmanuel J. H. J. Wiertz, Rutger D. Luteijn, Ingo Drexler, Robert Jan Lebbink, Ingrid G. J. Boer, Vincent A. Blomen, Ferdy R. van Diemen, Saravanan Manikam Sadasivam, Thijn R. Brummelkamp

Publikováno v: Journal of Virology
Journal of Virology, 93(13). American Society for Microbiology
Journal of Virology, 93
Journal of Virology, 93, 13

Contains fulltext : 205154.pdf (Publisher’s version ) (Closed access) Vaccinia virus is a promising viral vaccine and gene delivery candidate and has historically been used as a model to study poxvirus-host cell interactions. We employed a genome-w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ae9e481dbde429823b6a96365bc373
https://doi.org/10.1128/JVI.02160-18

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A genome-wide haploid genetic screen for essential factors in vaccinia virus infection identifies TMED10 as regulator of macropinocytosis

Autor: Ingo Drexler, Robert Jan Lebbink, Emmanuel J. H. J. Wiertz, Toin H. van Kuppevelt, Ferdy R. van Diemen, Vincent A. Blomen, Thijn R. Brummelkamp, Rutger D. Luteijn, Ingrid G. J. Boer, Saravanan Manikam Sadasivam

Vaccinia virus is a promising viral vaccine and gene delivery candidate, and has historically been used as a model to study poxvirus-host cell interactions. We employed a genome-wide insertional mutagenesis approach in human haploid cells to identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6725a093e77ca4cee5e54663e534fc
https://doi.org/10.1101/493205

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LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins

Autor: Klaus Aktories, Björn Schorch, Ferdy R. van Diemen, Shuo Song, Hans H. Bock, Thijn R. Brummelkamp, Joachim Herz, Panagiotis Papatheodorou, Petra May

Publikováno v: Proceedings of the National Academy of Sciences. 111:6431-6436

Large glycosylating toxins are major virulence factors of various species of pathogenic Clostridia. Prototypes are Clostridium difficile toxins A and B, which cause antibiotics-associated diarrhea and pseudomembranous colitis. The current model of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e8f47d56b3cfa1fa8fd02f44cb35f8
https://doi.org/10.1073/pnas.1323790111

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CRISPR/Cas9, a powerful tool to target human herpesviruses

Autor: Ferdy R, van Diemen, Robert Jan, Lebbink

Publikováno v: Cellular microbiology. 19(2)

Over 90% of the adult population is infected with one or multiple herpesviruses. These viruses are characterized by their ability to establish latency, where the host is unable to clear the invader from infected cells resulting in a lifelong infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65a8cacc28aa5c142327f19815d460af
https://pubmed.ncbi.nlm.nih.gov/27860066

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