Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ferdos Abid Ali"'
Autor:
Panchali Goswami, Ferdos Abid Ali, Max E. Douglas, Julia Locke, Andrew Purkiss, Agnieszka Janska, Patrik Eickhoff, Anne Early, Andrea Nans, Alan M. C. Cheung, John F. X. Diffley, Alessandro Costa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Eukaryotic origin firing depends on assembly of the Cdc45-MCM-GINS (CMG) helicase, which requires the leading-strand polymerase Pol ɛ. Here the authors present a structural analysis of a CMG Pol ɛ on a DNA fork, providing insight on the steps leadi
Externí odkaz:
https://doaj.org/article/9aa43b820ec5447a9b984fff5621c4e6
Autor:
Ferdos Abid Ali, Max E. Douglas, Julia Locke, Valerie E. Pye, Andrea Nans, John F. X. Diffley, Alessandro Costa
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Origins of replication are licensed by loading of MCM onto DNA, and origin firing depends on interaction with Cdc45 and GINS to form two CMG holo-helicases. Here, authors determine the cryo-EM structures of DNA-bound MCM and visualise a phospho-depen
Externí odkaz:
https://doaj.org/article/fb70ba000f734f91b445107c7b777e95
Autor:
Patrik Eickhoff, Hazal B. Kose, Fabrizio Martino, Tatjana Petojevic, Ferdos Abid Ali, Julia Locke, Nele Tamberg, Andrea Nans, James M. Berger, Michael R. Botchan, Hasan Yardimci, Alessandro Costa
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2673-2688.e8 (2019)
Summary: In the eukaryotic replisome, DNA unwinding by the Cdc45-MCM-Go-Ichi-Ni-San (GINS) (CMG) helicase requires a hexameric ring-shaped ATPase named minichromosome maintenance (MCM), which spools single-stranded DNA through its central channel. No
Externí odkaz:
https://doaj.org/article/9647e87219564b23adf3d2627b2f4a5f
Autor:
Ferdos Abid Ali, Ludovic Renault, Julian Gannon, Hailey L. Gahlon, Abhay Kotecha, Jin Chuan Zhou, David Rueda, Alessandro Costa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during replication, a process that requires the ATPase-dependent activity of the MCM complex. Using cryo-EM reconstructions of the CMG complex in different conformations, the authors propose a model where
Externí odkaz:
https://doaj.org/article/e8bcf31cfc344c0caf66a04f100182fe
Autor:
Andrew P. Carter, Ferdos Abid Ali, G.R. Mali, Juri Rappsilber, Jérôme Boulanger, Clinton K. Lau, Jonathan D. Howe, Farida Begum, Mark Skehel, Zhuo A. Chen
Publikováno v:
Science
Ciliary motors locked closed by Shulin Motile cilia and flagella are vital cellular organelles with functions that include setting up the left-right body axis, clearing airways of mucus, and driving single-cell movements. Cilia beating is powered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0739bcde230e26bac60508dd4ce36cbf
https://doi.org/10.1126/science.abe0526
https://doi.org/10.1126/science.abe0526
Autor:
Ferdos Abid Ali, Andrew Carter
Publikováno v:
Biophysical Journal. 122:411a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc8b7745d48a2ccf85df58d0a1f538c2
https://doi.org/10.1016/j.bpj.2022.11.2236
https://doi.org/10.1016/j.bpj.2022.11.2236
The main force generators in eukaryotic cilia and flagella are axonemal outer dynein arms (ODAs). During cilio-genesis, these ∼1.8 MDa complexes are assembled in the cytoplasm and targeted to cilia via an unknown mechanism. Here we use the ciliate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e260bbaf2b44772192727c73e3658ae
https://doi.org/10.1101/2020.09.04.282897
https://doi.org/10.1101/2020.09.04.282897
Autor:
John F.X. Diffley, Julia Locke, Ferdos Abid Ali, Max E. Douglas, Valerie E. Pye, Alessandro Costa, Andrea Nans
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Eukaryotic origins of replication are licensed upon loading of the MCM helicase motor onto DNA. ATP hydrolysis by MCM is required for loading and the post-catalytic MCM is an inactive double hexamer that encircles duplex DNA. Origin firing depends on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8e9858d93b702baa5299d1b86f3e10
https://doaj.org/article/fb70ba000f734f91b445107c7b777e95
https://doaj.org/article/fb70ba000f734f91b445107c7b777e95
Autor:
Hazal B. Kose, Julia Locke, Patrik Eickhoff, Tatjana Petojevic, Hasan Yardimci, Nele Tamberg, Ferdos Abid Ali, Fabrizio Martino, Andrea Nans, Alessandro Costa, James M. Berger, Michael R. Botchan
Publikováno v:
Cell Reports
Cell Reports, Vol 28, Iss 10, Pp 2673-2688.e8 (2019)
Cell Reports, Vol 28, Iss 10, Pp 2673-2688.e8 (2019)
Summary In the eukaryotic replisome, DNA unwinding by the Cdc45-MCM-Go-Ichi-Ni-San (GINS) (CMG) helicase requires a hexameric ring-shaped ATPase named minichromosome maintenance (MCM), which spools single-stranded DNA through its central channel. Not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9ae1d60ba6a1f5a4234448a7fd324c
https://pubmed.ncbi.nlm.nih.gov/31484077
https://pubmed.ncbi.nlm.nih.gov/31484077
Autor:
Ferdos Abid Ali, Alessandro Costa
Publikováno v:
Journal of Molecular Biology. 428:1822-1832
The MCM motor of the CMG helicase powers ahead of the eukaryotic replication machinery to unwind DNA, in a process that requires ATP hydrolysis. The reconstitution of DNA replication in vitro has established the succession of events that lead to repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bf5f7f322374b3f9bba9b994f7d7a0
https://doi.org/10.1016/j.jmb.2016.01.024
https://doi.org/10.1016/j.jmb.2016.01.024