Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ferdinando Maria Milazzo"'
Autor:
Ferdinando Maria Milazzo, Loredana Vesci, Anna Maria Anastasi, Caterina Chiapparino, Antonio Rosi, Giuseppe Giannini, Maurizio Taddei, Elena Cini, Valentina Faltoni, Elena Petricci, Gianfranco Battistuzzi, Laura Salvini, Valeria Carollo, Rita De Santis
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
Targeted therapy using monoclonal antibodies conjugated to toxins is gaining space in the treatment of cancer. Here, we report the anti-tumor effect of a new antibody drug conjugate (ADC) delivering a HDAC inhibitor to ErbB2+ solid tumors. Trastuzuma
Externí odkaz:
https://doaj.org/article/9cacfddaa65c4f5289baf37bf07c9122
Autor:
Franco Zunino, Claudio Cavazza, Paolo Carminati, Daniela Passeri, Augusto Orlandi, Valentina Zuco, Paola Perego, Monica Tortoreto, Giovanna Petrangolini, Massimo Zucchetti, Maurizio D'Incalci, Marcella Barbarino, Rosanna Foderà, Mario Berardino Guglielmi, Ferdinando Maria Milazzo, Loredana Vesci, Claudio Pisano
Purpose: Acetyl-l-carnitine (ALC) plays a relevant role in energy metabolism and stress response because of its function in the complex metabolic system regulating the acetyl-CoA levels that provide a source of acetyl groups for metabolic and acetyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491ac695a485ceb3b81abb9e02d9f54d
https://doi.org/10.1158/1078-0432.c.6519233.v1
https://doi.org/10.1158/1078-0432.c.6519233.v1
Autor:
Franco Zunino, Claudio Cavazza, Paolo Carminati, Daniela Passeri, Augusto Orlandi, Valentina Zuco, Paola Perego, Monica Tortoreto, Giovanna Petrangolini, Massimo Zucchetti, Maurizio D'Incalci, Marcella Barbarino, Rosanna Foderà, Mario Berardino Guglielmi, Ferdinando Maria Milazzo, Loredana Vesci, Claudio Pisano
Supplementary Figures S1-S2, Supplementary Materials and Methods, and Supplementary Tables S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcfa0370cc6132cda6f4246b52792b6
https://doi.org/10.1158/1078-0432.22442519
https://doi.org/10.1158/1078-0432.22442519
Autor:
Giuseppe Gritti, Maria Gabriella Santoro, Daniela Santapaola, Olga Minenkova, Bruno Pagano, Alessandro Rambaldi, Gianfranco Battistuzzi, Rita De Santis, Gianmaria Borleri, Caterina Chiapparino, Laura Salvini, Emilio Merlo Pich, Cécile Viollet, Antonio Rosi, Anna Maria Anastasi, Clélia Dental, Antonio Rossi, Laura Luberto, Ferdinando Maria Milazzo, Anna Riccio, Emanuele Marra
Publikováno v:
Molecular therapy
(2022). doi:10.1016/j.ymthe.2022.02.013
info:cnr-pdr/source/autori:Minenkova O.; Santapaola D.; Milazzo F.M.; Anastasi A.M.; Battistuzzi G.; Chiapparino C.; Rosi A.; Gritti G.; Borleri G.; Rambaldi A.; Dental C.; Viollet C.; Pagano B.; Salvini L.; Marra E.; Luberto L.; Rossi A.; Riccio A.; Merlo Pich E.; Santoro M.G.; De Santis R./titolo:Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy/doi:10.1016%2Fj.ymthe.2022.02.013/rivista:Molecular therapy (Print)/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume
(2022). doi:10.1016/j.ymthe.2022.02.013
info:cnr-pdr/source/autori:Minenkova O.; Santapaola D.; Milazzo F.M.; Anastasi A.M.; Battistuzzi G.; Chiapparino C.; Rosi A.; Gritti G.; Borleri G.; Rambaldi A.; Dental C.; Viollet C.; Pagano B.; Salvini L.; Marra E.; Luberto L.; Rossi A.; Riccio A.; Merlo Pich E.; Santoro M.G.; De Santis R./titolo:Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy/doi:10.1016%2Fj.ymthe.2022.02.013/rivista:Molecular therapy (Print)/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume
As of October 2021, coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a global emergency, and novel therapeutics are urgently needed. Here we describe human single chain variable fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e679834cc702fe42637f514ee848dae1
http://hdl.handle.net/11588/873896
http://hdl.handle.net/11588/873896
Autor:
Claudio Cianferotti, Rita De Santis, Gianfranco Battistuzzi, Caterina Chiapparino, Elena Petricci, Maurizio Taddei, Valentina Faltoni, Laura Salvini, Giuseppe Giannini, Francesca Migliorini, Elena Cini, Anna Maria Anastasi, Ferdinando Maria Milazzo, Elena Ermini
Antitumor hydroxamates SAHA and Dacinostat have been linked to cetuximab and trastuzumab through a non-cleavable linker based on the p-mercaptobenzyl alcohol structure. These antibody drug conjugates (ADCs) were able to inhibit HDAC in several tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4c9d5f8a403ecf88e00d9fc0ce2df7
http://hdl.handle.net/11365/1126953
http://hdl.handle.net/11365/1126953
Autor:
Gian Marco Elisi, Alessio Lodola, Silvia Rivara, Laura Scalvini, Giuseppe Giannini, Gilberto Spadoni, Gianfranco Battistuzzi, Daniele Pala, Giuseppe Roscilli, Emiliano Pavoni, Ferdinando Maria Milazzo, Marco Mor, Fabiana Fosca Ferrara
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1685-1696 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Heparanase is a validated target in cancer therapy and a potential target for several inflammatory pathologies. A ligand-based virtual screening of commercial libraries was performed to expand the chemical space of small-molecule inhibitors. The scre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e333e97e5652d79d3757bd13a5bdd51f
Autor:
Barbara Leoni, Rita De Santis, Loredana Vesci, Caterina Chiapparino, Antonio Rosi, Anna Maria Anastasi, Fiorella Petronzelli, Ferdinando Maria Milazzo
Publikováno v:
Oncotarget
// Ferdinando Maria Milazzo 1 , Anna Maria Anastasi 1 , Caterina Chiapparino 1 , Antonio Rosi 1 , Barbara Leoni 1 , Loredana Vesci 1 , Fiorella Petronzelli 1 , Rita De Santis 1 1 Biotech Products, Research and Development, Sigma-Tau SpA, 00071 Pomezi
Autor:
Ferdinando Maria Milazzo, Fiorella Petronzelli, Antonio Rosi, Rita De Santis, Gianfranco Battistuzzi, Anna Maria Anastasi, Giuseppe Giannini, Loredana Leone, Claudio Albertoni, Laura Salvini, Lorenzo Tei
Publikováno v:
Bioorganicmedicinal chemistry. 27(15)
Tenatumomab is an anti-tenascin murine monoclonal antibody previously used in clinical trials for delivering radionuclides to tumors by both pre-targeting (biotinylated Tenatumomab within PAGRIT) and direct 131Iodine labeling approaches. Here we pres
Publikováno v:
Future Medicinal Chemistry. 8:647-680
In recent years, heparanase has attracted considerable attention as a promising target for innovative pharmacological applications. Heparanase is a multifaceted protein endowed with enzymatic activity, as an endo-β-D-glucuronidase, and nonenzymatic
Autor:
Marco Mor, Emiliano Pavoni, Daniele Pala, Silvia Rivara, Giuseppe Giannini, Ferdinando Maria Milazzo, Giuseppe Roscilli
Publikováno v:
Glycobiology
Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes. A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making h